{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:47:15Z","timestamp":1756385235652,"version":"3.41.2"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T00:00:00Z","timestamp":1631318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory condition causing recurrent dysphagia and may predispose patients to repeated hospitalizations. We assessed temporal trends and factors affecting readmissions in patients with EoE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with primary diagnosis of EoE and\/or a complication (dysphagia, weight loss, and esophageal perforation) from EoE between 2010 and 2017 were identified from the National Readmissions Database using the International Classification of Diseases codes. The primary outcome was incidence of EoE related 30-day readmission. Independent risk factors for readmissions were evaluated using multivariable logistic regression analysis. Secondary outcomes were temporal trends of readmissions and healthcare costs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 2,676 (mean age 45\u2009\u00b1\u200917.8 years, 1,667 males) index adult admissions, 2,103 (79%) patients underwent an upper endoscopy during the admission. The mean length of stay (LOS) was 3\u2009\u00b1\u20093.7\u00a0days. The 30-day readmission rate was steady at 6.8% from 2010 to 2017 and majority of the readmissions occurred by day 10 of index discharge. Age\u2009&amp;gt;\u200970\u00a0years was associated with a higher trend in 30-day readmission (P\u2009&amp;lt;\u20090.001). Longer LOS, history of smoking and the presence of eosinophilic gastroenteritis predicted readmission. Conversely, a history of foreign body impaction and upper endoscopy (including esophageal dilation) at index admission were negatively associated with readmission. Mean hospital charges significantly increased from $24,783 in 2010 to $40,922 in 2017.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Readmissions due to EoE are more likely to occur in the first 10\u00a0days of discharge and at a lesser rate when upper endoscopies are performed at the index admission.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/dote\/doab060","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T02:31:19Z","timestamp":1631413879000},"source":"Crossref","is-referenced-by-count":1,"title":["Trends and predictors of 30-day readmissions in subjects with eosinophilic esophagitis: results from a national cohort"],"prefix":"10.1093","volume":"35","author":[{"given":"Sachin","family":"Srinivasan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Kansas School of Medicine- Wichita, Wichita, KS, USA"},{"name":"Department of Gastroenterology, Kansas City VA Medical Center, Kansas City, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6774-5451","authenticated-orcid":false,"given":"Suneha","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kansas City VA Medical Center, Kansas City, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin F","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kansas City VA Medical Center, Kansas City, MO, USA"},{"name":"Department of Biostatistics, St Luke's Medical Center, Kansas City, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7801-0044","authenticated-orcid":false,"given":"Divyanshoo R","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kansas City VA Medical Center, Kansas City, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Emura","sequence":"additional","affiliation":[{"name":"Department of GI Endoscopy, Emura Center Latino America, Bogota D.C., Colombia"},{"name":"Division of Gastroenterology, Universidad de La Sabana, Chia, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prateek","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kansas City VA Medical Center, Kansas City, MO, USA"},{"name":"Division of Gastroenterology, University of Kansas School of Medicine, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8871-3627","authenticated-orcid":false,"given":"Madhav","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kansas City VA Medical Center, Kansas City, MO, USA"},{"name":"Division of Gastroenterology, University of Kansas School of Medicine, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,9,11]]},"reference":[{"key":"2022021111532324500_ref1","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/0016-5085(78)90710-2","article-title":"Eosinophilic esophagitis in a patient with vigorous achalasia","volume":"74","author":"Landres","year":"1978","journal-title":"Gastroenterology"},{"key":"2022021111532324500_ref2","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/S0016-5085(77)80034-6","article-title":"Eosinophilic gastroenteritis with esophageal involvement","volume":"72","author":"Dobbins","year":"1977","journal-title":"Gastroenterology"},{"key":"2022021111532324500_ref3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF01296781","article-title":"Esophageal eosinophilia with dysphagia. A distinct clinicopathologic syndrome","volume":"38","author":"Attwood","year":"1993","journal-title":"Dig Dis Sci"},{"key":"2022021111532324500_ref4","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1053\/j.gastro.2020.02.039","article-title":"Technical review on the Management of Eosinophilic Esophagitis: a report from the AGA institute and the joint task force on allergy-immunology practice parameters","volume":"158","author":"Rank","year":"2020","journal-title":"Gastroenterology"},{"key":"2022021111532324500_ref5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1053\/j.gastro.2017.06.067","article-title":"Epidemiology and natural history of eosinophilic esophagitis","volume":"154","author":"Dellon","year":"2018","journal-title":"Gastroenterology"},{"key":"2022021111532324500_ref6","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/all.12733","article-title":"Escalating incidence of eosinophilic esophagitis in Canton of Vaud, Switzerland, 1993\u20132013: a population-based study","volume":"70","author":"Giriens","year":"2015","journal-title":"Allergy"},{"key":"2022021111532324500_ref7","first-page":"495","article-title":"Health-related quality of life and costs associated with eosinophilic esophagitis: a systematic review","volume":"16","author":"Mukkada","year":"2018","journal-title":"Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc"},{"key":"2022021111532324500_ref8","doi-asserted-by":"crossref","first-page":"S669","DOI":"10.1016\/S0016-5085(16)32277-6","article-title":"Mo1202 Underdiagnosis of eosinophilic esophagitis (EoE) related esophageal foreign body impactions in national inpatient sample","volume":"150","author":"Wadhwa","year":"2016","journal-title":"Gastroenterology"},{"key":"2022021111532324500_ref9","first-page":"S171","article-title":"Cost comparison of steroids vs different elimination diet for the treatment of eosinophilic esophagitis in children","volume":"63","author":"Schwartz","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2022021111532324500_ref10","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/ajg.2014.316","article-title":"Health-care utilization, costs, and the burden of disease related to eosinophilic esophagitis in the United States","volume":"110","author":"Jensen","year":"2015","journal-title":"Am J Gastroenterol"},{"author":"Nationwide Readmissions Database Overview","key":"2022021111532324500_ref11"},{"key":"2022021111532324500_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.09.012","article-title":"Safety of endoscopic gastrostomy tube placement compared with radiological or surgical gastrostomy: nationwide inpatient assessment","author":"Kohli","year":"2020","journal-title":"Gastrointest Endosc"},{"key":"2022021111532324500_ref13","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0895-4356(92)90133-8","article-title":"Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases","volume":"45","author":"Deyo","year":"1992","journal-title":"J Clin Epidemiol"},{"key":"2022021111532324500_ref14","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/nmo.12323","article-title":"Disease duration determines health-related quality of life in adult eosinophilic esophagitis patients. Neurogastroenterol","volume":"26","author":"Van Rhijn","year":"2014","journal-title":"Motil Off J Eur Gastrointest Motil Soc"},{"key":"2022021111532324500_ref15","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/apt.13370","article-title":"Eosinophilic oesophagitis: relationship of quality of life with clinical, endoscopic and histological activity","volume":"42","author":"Safroneeva","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"2022021111532324500_ref16","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/MCG.0b013e3182166a5a","article-title":"Qualitative assessment of patient-reported outcomes in adults with eosinophilic esophagitis","volume":"45","author":"Taft","year":"2011","journal-title":"J Clin Gastroenterol"},{"key":"2022021111532324500_ref17","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1007\/s10620-018-5045-0","article-title":"Assessing adherence and barriers to long-term elimination diet therapy in adults with eosinophilic esophagitis","volume":"63","author":"Wang","journal-title":"Dig Dis Sci"},{"key":"2022021111532324500_ref18","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1007\/s10620-017-4642-7","article-title":"Six-food elimination diet and topical steroids are effective for eosinophilic esophagitis: a meta-regression","volume":"62","author":"Cotton","year":"2017","journal-title":"Dig Dis Sci"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/35\/2\/doab060\/42497676\/doab060.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/35\/2\/doab060\/42497676\/doab060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T11:53:53Z","timestamp":1644580433000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article\/doi\/10.1093\/dote\/doab060\/6369007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,11]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,9,11]]},"published-print":{"date-parts":[[2022,2,11]]}},"URL":"https:\/\/doi.org\/10.1093\/dote\/doab060","relation":{},"ISSN":["1120-8694","1442-2050"],"issn-type":[{"type":"print","value":"1120-8694"},{"type":"electronic","value":"1442-2050"}],"subject":[],"published-other":{"date-parts":[[2022,2]]},"published":{"date-parts":[[2021,9,11]]},"article-number":"doab060"}}