{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:11:27Z","timestamp":1790197887688,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Japanese Gastroenterological Association","award":["2021-1"],"award-info":[{"award-number":["2021-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Geriatric patients with existing studies on the safety and efficacy of peroral endoscopic myotomy (POEM) for achalasia involve small sample sizes and single institutions. However, multi-center, large-scale data analyses are lacking. The study aimed to clarify the characteristics of geriatric patients with esophageal motility disorders (EMDs) and determine the procedure-related outcomes and clinical course following POEM. This cohort study included 2,735 patients with EMDs who were treated at seven Japanese facilities between 2010 and 2019. The patients\u2019 characteristics and post-POEM clinical courses were compared between the geriatric (age\u2009\u2265\u200975\u00a0years; n\u2009=\u2009321) and non-geriatric (age\u2009&amp;lt;\u200975\u00a0years; n\u2009=\u20092,414) groups. Compared with the non-geriatric group, the geriatric group had higher American Society of Anesthesiologists physical status scores; more recurrent cases; lower incidence of chest pain; and higher incidence of type III achalasia, distal esophageal spasm, and Jackhammer esophagus. Furthermore, the incidence of sigmoid esophagus was higher, although esophageal dilation was not severe in this group. POEM was safe and effective for geriatric patients with treatment-na\u00efve and recurrent EMDs. Furthermore, compared with the non-geriatric group, the geriatric group had lower post-POEM Eckardt scores, fewer complaints of refractory chest pain, and a lower incidence rate of post-POEM reflux esophagitis. Geriatric patients are characterized by worse clinical conditions, more spastic disorders, and greater disease progression of EMDs, which are also the indications for minimally invasive POEM. POEM is more beneficial in geriatric patients as it has lowering symptom scores and incidence rates of reflux esophagitis.<\/jats:p>","DOI":"10.1093\/dote\/doab086","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T22:52:59Z","timestamp":1640213579000},"source":"Crossref","is-referenced-by-count":8,"title":["Geriatric patients with esophageal motility disorders benefit more from minimally invasive peroral endoscopic myotomy: a multicenter study in Japan"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9431-0912","authenticated-orcid":false,"given":"Naoto","family":"Ujiie","sequence":"first","affiliation":[{"name":"Department of Surgery , , Sendai, Japan"},{"name":"Tohoku University Graduate School of Medicine , , Sendai, Japan"},{"name":"Department of Medicine , Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute, Northwestern University, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7766-3724","authenticated-orcid":false,"given":"Hiroki","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology , Graduate School of Medical and Dental Sciences, , Niigata, Japan"},{"name":"Niigata University , Graduate School of Medical and Dental Sciences, , Niigata, Japan"},{"name":"Division of Gastroenterology and Hepatology , Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Raina Angeli","family":"Fujiyoshi","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center , , Tokyo, Japan"},{"name":"Showa University Koto-Toyosu Hospital , , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinwa","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology , , Kobe, Japan"},{"name":"Kobe University Hospital , , Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironari","family":"Shiwaku","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery , , Fukuoka, Japan"},{"name":"Fukuoka University Faculty of Medicine , , Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Shiota","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology , , Nagasaki, Japan"},{"name":"Nagasaki University Hospital , , Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology , Faculty of Medicine, , Oita, Japan"},{"name":"Oita University , Faculty of Medicine, , Oita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yokomichi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences , , Yamanashi, Japan"},{"name":"University of Yamanashi , , Yamanashi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kamei","sequence":"additional","affiliation":[{"name":"Department of Surgery , , Sendai, Japan"},{"name":"Tohoku University Graduate School of Medicine , , Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiro","family":"Inoue","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center , , Tokyo, Japan"},{"name":"Showa University Koto-Toyosu Hospital , , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"2022061508274776600_ref1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0140-6736(13)60651-0","article-title":"Achalasia","volume":"383","author":"Boeckxstaens","year":"2014","journal-title":"Lancet"},{"key":"2022061508274776600_ref2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00535-018-01544-8","article-title":"Epidemiological analysis of achalasia in Japan using a large-scale claims database","volume":"54","author":"Sato","year":"2019","journal-title":"J Gastroenterol"},{"key":"2022061508274776600_ref3","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1007\/s00464-019-07070-9","article-title":"Effect of peroral endoscopic myotomy in geriatric patients: a propensity score matching study","volume":"34","author":"Liu","year":"2020","journal-title":"Surg 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