{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:55:25Z","timestamp":1775195725529,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Background: The failure-rate after primary antireflux surgery ranges from 3 to 30%. Reasons for failures are multifactorial. The aim of this study is to gain insight into the complex reasons for, and management of, failure after antireflux surgery. Methods: Patients were selected for redo-surgery after a diagnostic workup consisting of history and physical examination, upper gastrointestinal endoscopy, quality-of-life assessment, screening for somatoform disorders, esophageal manometry, 24-hour-pH-impedance monitoring, and selective radiographic studies such as Barium-sandwich for esophageal passage and delayed gastric emptying. Perioperative and follow-up data were compiled between 2004 and 2017. Results: In total, 578 datasets were analyzed. The patient cohort undergoing a first redo-procedure (n\u2009=\u2009401) consisted of 36 patients after in-house primary LF and 365 external referrals (mean age: 62.1\u00a0years [25\u201387]; mean BMI 26 [20\u201334]). The majority of patients underwent a repeated total or partial laparoscopic fundoplication. Major reasons for failure were migration and insufficient mobilization during the primary operation. With each increasing number of required redo-operations, the complexity of the redo-procedure itself increased, follow-up quality-of-life decreased (GIQLI: 106; 101; and 100), and complication rate increased (intraoperative: 6,4\u201310%; postoperative: 4,5\u201319%\/first to third redo). After three redo-operations, resections were frequently necessary (morbidity: 42%). Conclusions: Providing a careful patient selection, primary redo-antireflux procedures have proven to be highly successful. It is often the final chance for a satisfying result may be achieved upon performing a second redo-procedure. A third revision may solve critical problems, such as severe pain and\/or inadequate nutritional intake. When resection is required, quality of life cannot be entirely normalized.<\/jats:p>","DOI":"10.1093\/dote\/doab091","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T22:51:24Z","timestamp":1640904684000},"source":"Crossref","is-referenced-by-count":9,"title":["How effective is laparoscopic redo-antireflux surgery?"],"prefix":"10.1093","volume":"35","author":[{"given":"K H","family":"Fuchs","sequence":"first","affiliation":[{"name":"Laboratory for Interventional and Experimental Endoscopy, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Breithaupt","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, St. Elisabethen Krankenhaus, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Varga","sequence":"additional","affiliation":[{"name":"AGAPLESION Markus Krankenhaus, Department of General and Visceral Surgery, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Babic","sequence":"additional","affiliation":[{"name":"University of Cologne, Department of General-, Visceral-and Cancer Surgery, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Eckhoff","sequence":"additional","affiliation":[{"name":"University of Cologne, Department of General-, Visceral-and Cancer Surgery, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Meining","sequence":"additional","affiliation":[{"name":"Laboratory for Interventional and Experimental Endoscopy, University of W\u00fcrzburg, W\u00fcrzburg, Germany"},{"name":"University of W\u00fcrzburg, Zentrum Innere Medizin, Head of Gastroenterology, W\u00fcrzburg, 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