{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:58:44Z","timestamp":1788469124365,"version":"build-2803163510"},"reference-count":36,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Esophageal atresia (EA) is a rare congenital disease which is usually not of the detected prenatally. Due to the lack of prenatal diagnosis, some newborns with EA are born outside of specialized centers. Nevertheless, centralized care of EA has been proposed, even if a clear volume\u2013outcome association in EA management remains unconfirmed. Furthermore, whether outcomes differ between outborn and inborn patients with EA has not been systematically investigated. Therefore, this single-center, retrospective study aimed to investigate EA management and outcomes with a special focus on inborn versus outborn patients. The following data were extracted from the medical records of infants with EA from 2009 to 2019: EA type, associated anomalies, complications, and long-term outcome. Patients were allocated into inborn and outborn groups. Altogether, 57 patients were included. Five patients were excluded (referral before surgery, loss of data, death before surgery [n\u2009=\u20091], and incorrect diagnosis [diverticulum, n\u2009=\u20091]). Among all patients, the overall survival rate was 96%, with no mortalities among outborn patients. The overall hospitalization period was shorter for outborn patients. The median follow-up durations were 3.8\u00a0years and 3.2\u00a0years for inborn and outborn patients, respectively. Overall, 15% of patients underwent delayed primary anastomosis (long-gap atresia [n\u2009=\u20094] and other reasons [n\u2009=\u20094]). Early complications included three anastomotic leakages and one post-operative fistula; 28% of patients developed strictures, which required dilatation, and 38% of patients showed relevant gastroesophageal reflux, which required fundoplication, without any differences between the groups. The two groups had comparable low mortality and expected high morbidity with no significant differences in outcome. The outborn group showed nonsignificant trends toward lower morbidity and shorter hospitalization periods, which might be explained by the overall better clinical status.<\/jats:p>","DOI":"10.1093\/dote\/doab092","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T23:46:16Z","timestamp":1641944776000},"source":"Crossref","is-referenced-by-count":5,"title":["Outcome of esophageal atresia: inborn versus outborn patients"],"prefix":"10.1093","author":[{"given":"Denise","family":"Schlee","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Urology, University Hospital Frankfurt\/M., Goethe-University Frankfurt\/Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till-Martin","family":"Theilen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Urology, University Hospital Frankfurt\/M., Goethe-University Frankfurt\/Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Fiegel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Urology, University Hospital Frankfurt\/M., Goethe-University Frankfurt\/Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hutter","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Urology, University Hospital Frankfurt\/M., Goethe-University Frankfurt\/Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Rolle","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Urology, University Hospital Frankfurt\/M., Goethe-University Frankfurt\/Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"2022011123460997800_ref1","first-page":"357","article-title":"The surgical correction of congenital deformities","volume":"112","author":"Wessel","year":"2015","journal-title":"Dtsch Arztebl Int"},{"key":"2022011123460997800_ref2","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.jpedsurg.2016.02.001","article-title":"Accurary of prenatal detection of tracheoesophageal fistula and oesophageal atresia","volume":"51","author":"Bradshaw","year":"2016","journal-title":"J Pediatr Surg"},{"key":"2022011123460997800_ref3","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/aogs.13536","article-title":"Prenatal detection of esophageal atresia: a systematic review and meta-analysis","volume":"98","author":"Pardy","year":"2019","journal-title":"Acta Obstet GynecolScand"},{"issue":"28","key":"2022011123460997800_ref4","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.3748\/wjg.v18.i28.3662","article-title":"Current knowledge on esophageal atresia","volume":"18","author":"Pinheiro","year":"2021","journal-title":"WJG"},{"issue":"6","key":"2022011123460997800_ref5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1055\/s-0039-3400284","article-title":"ERNICA consensus conference on the management of patients with esophageal atresia and tracheoesophageal fistula: follow-up and framework","volume":"30","author":"Dingemann","year":"2020","journal-title":"Eur J Pediatr Surg"},{"key":"2022011123460997800_ref6","first-page":"463","article-title":"Congenital esophageal atresia","volume":"22","author":"Vogt","year":"1929","journal-title":"Am J Roentgenol"},{"key":"2022011123460997800_ref7","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1056\/NEJM194405252302101","article-title":"The surgical treatment of esophageal atresia and tracheoesophageal fistulas","volume":"230","author":"Ladd","year":"1944","journal-title":"N Engl J Med"},{"key":"2022011123460997800_ref8","volume-title":"The Surgery of Infancy and Childhood","author":"Gross","year":"1953"},{"key":"2022011123460997800_ref9","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0140-6736(62)91837-8","article-title":"Oesophageal atresia: tracheoesophageal fistula. A study of survival in 218 infants","author":"Waterston","year":"1962","journal-title":"Lancet"},{"key":"2022011123460997800_ref10","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.jpedsurg.2016.03.010","article-title":"Outcome and management in infants with esophageal atresia \u2013 a single centre observational study","volume":"51","author":"Donoso","year":"2016","journal-title":"J Pediatr Surg"},{"key":"2022011123460997800_ref11","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.surg.2014.03.016","article-title":"Morbidity and mortality in patients with esophageal atresia","volume":"156","author":"Sulkowski","year":"2014","journal-title":"Surgery"},{"key":"2022011123460997800_ref12","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.jss.2014.04.033","article-title":"A nationwide analysis of clinical outcomes among newborns with esophageal atresia and tracheoesophageal fistulas in the United States","volume":"190","author":"Wang","year":"2014","journal-title":"J Surg Res"},{"key":"2022011123460997800_ref13","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1308\/rcsann.2020.0087","article-title":"Repair of esophageal atresia by consultants and supervised trainees results in similar outcomes","volume":"102","author":"Jones","year":"2020","journal-title":"Ann R Australas Coll Dent Surg"},{"key":"2022011123460997800_ref14","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.jpedsurg.2016.02.014","article-title":"Weekday vs. weekend repair of esophageal atresia and tracheoesophageal fistula","volume":"51","author":"Sayari","year":"2016","journal-title":"J Ped Surgery"},{"key":"2022011123460997800_ref15","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.jpedsurg.2015.02.036","article-title":"A comparison of surgical outcomes between in-hours and after-hours tracheoesophageal fistula repairs","volume":"50","author":"Yeung","year":"2015","journal-title":"J Pediatr Surg"},{"key":"2022011123460997800_ref16","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.jpedsurg.2016.11.046","article-title":"Perioperative management and outcomes of esophageal atresia and tracheoesophageal fistula","volume":"52","author":"Lal","year":"2017","journal-title":"J Pediatr Surg"},{"key":"2022011123460997800_ref17","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jpedsurg.2016.11.010","article-title":"Multicentre survey on the current surgical mangement of oesophageal atresia in Belgium and Luxembourg","volume":"52","author":"Reusens","year":"2017","journal-title":"J Pediatr Surg"},{"key":"2022011123460997800_ref18","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s11605-017-3423-0","article-title":"Postoperative complications and functional outcome after esophageal atresia repair: results from longitudinal single-center follow-up","volume":"21","author":"Friedmacher","year":"2017","journal-title":"J Gastrointest Surg"},{"key":"2022011123460997800_ref19","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jpedsurg.2017.11.011","article-title":"Outcomes of fundoplication in oesophageal atresia associated gastrooesophageal reflux disease","volume":"53","author":"Koivusalo","year":"2018","journal-title":"J Pediatr Surg"},{"key":"2022011123460997800_ref20","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jpedsurg.2018.07.023","article-title":"Surgical repair of long-gap esophageal atresia: a retrospective study comparing the management of long-gap esophageal atresia in the Nordic contries","volume":"54","author":"Stadil","year":"2019","journal-title":"J Pediatr Surg"},{"key":"2022011123460997800_ref21","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s00383-019-04525-x","article-title":"Neonatal surgery in low- vs. high-volume institutions: a KID inpatient database outcomes and cost study after repair of congenital diaphragmatic hernia, esophageal atresia, and gastroschisis","volume":"35","author":"Somme","year":"2019","journal-title":"Ped Surg International"},{"key":"2022011123460997800_ref22","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1016\/j.jpedsurg.2021.04.006","article-title":"Association of operative approach with outcomes in neonates with esophageal atresia and tracheoesophageal fistula","volume":"56","author":"Etchill","year":"2021","journal-title":"J Pediatr Surg"},{"key":"2022011123460997800_ref23","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.jpedsurg.2020.11.023","article-title":"Influence of birth weight on primary surgical management of newborns with esophageal atresia","volume":"56","author":"Folaranmi","year":"2021","journal-title":"J Pediatr Surg"},{"key":"2022011123460997800_ref24","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s00383-017-4124-1","article-title":"Mortality and morbidity in oesophageal atresia","volume":"33","author":"Peters","year":"2017","journal-title":"Pediatr Surg Int"},{"key":"2022011123460997800_ref25","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jpedsurg.2020.01.025","article-title":"Nationwide analysis of mortality and hospital readmissions in esophageal atresia","volume":"55","author":"Quiros","year":"2020","journal-title":"J Pediatr Surg"},{"key":"2022011123460997800_ref26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jpeds.2021.02.064","article-title":"Risk factors of early mortality and morbidity in esophageal atresia with distal tracheoesophageal fistula: a population-based cohort study","volume":"234","author":"Sfeir","year":"2021","journal-title":"J Pediatr"},{"key":"2022011123460997800_ref27","first-page":"1","article-title":"Outcome of esophageal atresia in Germany","volume":"00","author":"Schmedding","year":"2020","journal-title":"Dis Esophagus"},{"key":"2022011123460997800_ref28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jpedsurg.2018.10.037","article-title":"Relationships between hospital and surgeon operative volumes and outcomes of esophageal atresia\/tracheoesophageal fistula repair","volume":"54","author":"Lawrence","year":"2019","journal-title":"J Pediatr Surg"},{"issue":"8","key":"2022011123460997800_ref29","doi-asserted-by":"crossref","first-page":"e106149","DOI":"10.1371\/journal.pone.0106149","article-title":"Outcomes at one-year post anastomosis from a nationwide cohort of infants with oesophageal atresia","volume":"9","author":"Allin","year":"2014","journal-title":"PLoS One"},{"key":"2022011123460997800_ref30","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00383-020-04664-6","article-title":"The value of prophylactic chest tubes in tracheoesophageal fistula repair","volume":"36","author":"Nguyen","year":"2020","journal-title":"Pediatr Surg Int"},{"key":"2022011123460997800_ref31","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s00383-018-4307-4","article-title":"A chest tube may not be needed after surgical repair of esophageal atresia and tracheoesophageal fistula","volume":"34","author":"Gawad","year":"2018","journal-title":"Pediatr Surg Int"},{"key":"2022011123460997800_ref32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpedsurg.2021.06.015","article-title":"Whether prophylactic intraoperative chest drain insertion in esophageal atresia-tracheoesophageal fistula is an evidence-based practice or just a prejudice: a systematic review and metananlysis","author":"Anand","year":"2021","journal-title":"J Pediatr Surg"},{"key":"2022011123460997800_ref33","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/s12887-018-1359-5","article-title":"What is the impact of the use of transanastomotic feeding tube on pateints with esophageal atresia: a systematic review and meta-analysis","volume":"18","author":"Wang","year":"2018","journal-title":"BMC Pediatr"},{"key":"2022011123460997800_ref34","doi-asserted-by":"crossref","DOI":"10.1038\/s41390-021-01510-w","article-title":"Prevalence of acid gastroesophageal reflux disease in infants with esophageal atresia\/tracheoesophageal fistula","author":"Flatres","year":"2021","journal-title":"Pediatr Res"},{"key":"2022011123460997800_ref35","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.645511","article-title":"Risk factors for recurrent tracheoesophageal fistula after Gross type C esophageal atresia repair","author":"Yang","year":"2021","journal-title":"Front Pediatr"},{"key":"2022011123460997800_ref36","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00383-020-04829-3","article-title":"Thorascopic oesophageal atresia\/trachea-oesophageal fistula (OA\/TF) repair is associated with a higher stricture rate: a single institutions\u2019s experience","volume":"37","author":"Thakkar","year":"2021","journal-title":"Pediatr Surg Int"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/dote\/advance-article-pdf\/doi\/10.1093\/dote\/doab092\/42106881\/doab092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dote\/advance-article-pdf\/doi\/10.1093\/dote\/doab092\/42106881\/doab092.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T23:46:43Z","timestamp":1641944803000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/advance-article\/doi\/10.1093\/dote\/doab092\/6500727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,7]]},"references-count":36,"URL":"https:\/\/doi.org\/10.1093\/dote\/doab092","relation":{},"ISSN":["1120-8694","1442-2050"],"issn-type":[{"value":"1120-8694","type":"print"},{"value":"1442-2050","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,7]]},"article-number":"doab092"}}