{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:47:05Z","timestamp":1753876025876,"version":"3.41.2"},"reference-count":30,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T00:00:00Z","timestamp":1642204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The long-term outcomes after esophagectomy for esophageal cancer remain uncertain and the optimal surveillance strategy after curative surgery remains controversial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this study, the clinicopathological characteristics of patients who underwent curative thoracic esophagectomy between 1991 and 2015 at Toranomon Hospital were retrospectively analyzed and reviewed until December 2020. We evaluated the accumulated data regarding the pattern and rates of recurrence and second malignancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1054 patients were eligible for inclusion in the study. Of these, 97% were followed up for 5\u00a0years, and the outcomes after 25\u00a0years could be determined in 65.5%. Recurrence was diagnosed in 318 patients (30.2%), and the most common pattern was lymph node metastasis (n\u2009=\u2009168, 52.8%). Recurrence was diagnosed within 1\u00a0year in 174 patients (54.7%) and within 3\u00a0years in 289 (90.9%). Second malignancy possibly occurred through the entire study period after esophagectomy even in early-stage cancer, keeping 2%\u20135% of the incidental risk. There was no significant difference in the prognosis between 3-year survivors with and without a second malignancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Most recurrences after resection of esophageal cancer occurred within 3\u00a0years regardless of disease stage. However, these patients have an ongoing risk of developing a second malignancy after esophagectomy. Further consideration is required regarding the efficacy of long-term surveillance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/dote\/doab098","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T13:56:56Z","timestamp":1642255016000},"source":"Crossref","is-referenced-by-count":2,"title":["Importance of long-term surveillance after curative esophagectomy for esophageal squamous cell carcinoma"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1755-1090","authenticated-orcid":false,"given":"Akikazu","family":"Yago","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Ohkura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentoku","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Shimoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusuke","family":"Haruta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2376-202X","authenticated-orcid":false,"given":"Harushi","family":"Udagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,1,15]]},"reference":[{"key":"2022011513564234100_ref1","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.3748\/wjg.v19.i34.5598","article-title":"Epidemiology of esophageal cancer","volume":"19","author":"Zhang","year":"2013","journal-title":"World J Gastroenterol"},{"key":"2022011513564234100_ref2","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/s00268-011-0978-x","article-title":"Treatment outcome and prognosis of patients with lymph node recurrence of thoracic esophageal squamous cell carcinoma after curative resection","volume":"35","author":"Kosuga","year":"2011","journal-title":"World J Surg"},{"key":"2022011513564234100_ref3","doi-asserted-by":"crossref","first-page":"855","DOI":"10.6004\/jnccn.2019.0033","article-title":"Esophageal and esophagogastric junction cancers, version 2.2019, NCCN clinical practice guidelines in oncology","volume":"17","author":"Ajani","year":"2019","journal-title":"J Natl Compr Canc Netw"},{"issue":"suppl 5","key":"2022011513564234100_ref4","doi-asserted-by":"crossref","first-page":"v50","DOI":"10.1093\/annonc\/mdw329","article-title":"ESMO Guidelines Committee. 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