{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:09:38Z","timestamp":1781244578673,"version":"3.54.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Up to 45% of esophageal atresia (EA) patients undergo fundoplication during childhood. Their esophageal dysmotility may predispose to worse fundoplication outcomes compared with patients without EA. We therefore compared fundoplication outcomes and symptoms pre- and post-fundoplication in EA patients with matched patients without EA. A retrospective review of patients with- and without EA who underwent a fundoplication was performed between 2006 and 2017. Therapeutic success was defined as complete sustained resolution of symptoms that were the reason to perform fundoplication. Fundoplication indications of 39 EA patients (49% male; median age 1.1 [0.1\u201317.0] yrs) and 39 non-EA patients (46% male; median age 1.3 [0.3\u201317.0] yrs) included respiratory symptoms, brief resolved unexplained events, typical symptoms of gastroesophageal reflux disease, recurrent strictures and respiratory problems. Post-fundoplication, therapeutic success was achieved in 5 (13%) EA patients versus 29 (74%) non-EA patients (P&amp;lt;0.001). Despite therapeutic success, all 5 (13%) EA patients developed postoperative sustained symptoms\/complications versus 12 (31%) non-EA patients. Eleven (28%) EA patients versus 3 (8%) non-EA patients did not achieve any therapeutic success (P=0.036). Remaining patients achieved partial therapeutic success. EA patients suffered significantly more often from postoperative sustained dysphagia (41% vs. 13%; P=0.039), gagging (33% vs. 23%; P&amp;lt;0.001) and bloating (40% vs. 17%; P=0.022). Fundoplication outcomes in EA patients are poor and EA patients are more susceptible to post-fundoplication sustained symptoms and complications compared with patients without EA. The decision to perform fundoplication in EA patients with proven gastroesophageal reflux disease needs to be made with caution after thorough multidisciplinary evaluation.<\/jats:p>","DOI":"10.1093\/dote\/doac006","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T03:28:56Z","timestamp":1645759736000},"source":"Crossref","is-referenced-by-count":14,"title":["Fundoplication in children with esophageal atresia: preoperative workup and outcome"],"prefix":"10.1093","author":[{"given":"Marinde","family":"van Lennep","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Sydney Children\u2019s Hospital, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Jiwane","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Sydney Children\u2019s Hospital, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra","family":"Saoji","sequence":"additional","affiliation":[{"name":"Children\u2019s Surgical and Endoscopy Center, Midas Heights, Nagpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon R","family":"Gorter","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A","family":"Benninga","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Sydney Children\u2019s Hospital, Sydney, New South Wales, Australia"},{"name":"Discipline of Paediatrics, School of Women\u2019s and Children\u2019s Health, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel P","family":"van Wijk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Department of Pediatric Gastroenterology, Emma Children\u2019s Hospital, Amsterdam UMC, Vrije Universiteit, Amsterdam, The 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