{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:41:46Z","timestamp":1780724506338,"version":"3.54.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Esophageal motility disorders (EMD) may be considered primary disorders only in the absence of gastroesophageal reflux disease (GERD). If GERD is present, treatment should be directed toward correction of the abnormal reflux. The actual prevalence of GERD in manometric dysmotility patterns according to the new Chicago Classification 4.0 (CC4) is still elusive. This study aims to evaluate the prevalence of GERD in patients with esophageal motility disorders according to the CC4. We reviewed 400 consecutive patients that underwent esophageal manometry and pH monitoring. Esophageal motility was classified according to the CC4 and GERD + was defined by a DeMeester score\u2009&amp;gt;\u200914.7. Normal motility or unclassified dysmotility was present in 290 (73%) patients, with GERD+ in 184 of them (63%). There were a total of 110 patients (27%) with named esophageal motility disorders, with GERD+ in 67 (61%). The incidence of ineffective esophageal motility was 59% (n\u2009=\u200965) with 69% GERD +, diffuse esophageal spasm was 40% (n\u2009=\u200944) with 48% GERD +, and hypercontractile esophagus was 0.01% (n\u2009=\u20091) with 100% GERD +. There was no correlation between the presence of GERD and the number of non-peristaltic swallows. Our results show that: (i) manometry only is not enough to select patients\u2019 treatment as &amp;gt;60% of patients with named esophageal motility disorders have GERD; (ii) there was no correlation between the presence of GERD and the number of non-peristaltic swallows.<\/jats:p>","DOI":"10.1093\/dote\/doac023","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T06:52:29Z","timestamp":1650955949000},"source":"Crossref","is-referenced-by-count":6,"title":["The prevalence of gastroesophageal reflux disease in named manometric patterns of dysmotility according to the Chicago Classification 4.0"],"prefix":"10.1093","author":[{"given":"Filipe","family":"de Padua","sequence":"first","affiliation":[{"name":"Department of Surgery, Federal University of Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando A M","family":"Herbella","sequence":"additional","affiliation":[{"name":"Department of Surgery, Federal University of Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil"},{"name":"Hospital S\u00e3o Luiz Morumbi, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco G","family":"Patti","sequence":"additional","affiliation":[{"name":"Department of Surgery, Federal University of Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"issue":"4","key":"2022042606521554400_ref1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.5056\/jnm17026","article-title":"Understanding the Chicago classification: from tracings to patients","volume":"23","author":"Schlottmann","year":"2017","journal-title":"J Neurogastroenterol Motil"},{"issue":"2","key":"2022042606521554400_ref2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/lap.2008.0317","article-title":"Primary versus secondary esophageal motility disorders: diagnosis and implications for treatment","volume":"19","author":"Herbella","year":"2009","journal-title":"J Laparoendosc Adv Surg Tech A"},{"issue":"1","key":"2022042606521554400_ref3","doi-asserted-by":"crossref","first-page":"e14058","DOI":"10.1111\/nmo.14058","article-title":"Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0\u00a9","volume":"33","author":"Yadlapati","year":"2021","journal-title":"Neurogastroenterol Motil"},{"issue":"5","key":"2022042606521554400_ref4","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s12325-021-01714-w","article-title":"Changes in the treatment of primary esophageal motility disorders imposed by the new classification for esophageal motility disorders on high resolution manometry (Chicago Classification 4.0)","volume":"38","author":"Herbella","year":"2021","journal-title":"Adv Ther"},{"issue":"4","key":"2022042606521554400_ref5","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.cgh.2015.10.006","article-title":"Identification of quality measures for performance of and interpretation of data from esophageal manometry","volume":"14","author":"Yadlapati","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"Suppl 1","key":"2022042606521554400_ref6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1590\/s0004-2803.201800000-40","article-title":"Normative values for a new water-perfused high resolution manometry system","volume":"55Suppl 1","author":"Silva","year":"2018","journal-title":"Arq Gastroenterol"},{"issue":"4","key":"2022042606521554400_ref7","doi-asserted-by":"crossref","first-page":"e1557","DOI":"10.1590\/0102-672020200004e1557","article-title":"Validation of a new water-perfused high-resolution manometry system","volume":"33","author":"Mariotto","year":"2021","journal-title":"Arq Bras Cir Dig"},{"issue":"3","key":"2022042606521554400_ref8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/gut.2007.127993","article-title":"Oesophageal high-resolution manometry: moving from research into clinical practice","volume":"57","author":"Fox","year":"2008","journal-title":"Gut"},{"issue":"6","key":"2022042606521554400_ref9","doi-asserted-by":"crossref","first-page":"e14090","DOI":"10.1111\/nmo.14090","article-title":"Chicago classification version 4.0\u00a9 from surgeons' point of view","volume":"33","author":"Herbella","year":"2021","journal-title":"Neurogastroenterol Motil"},{"issue":"2","key":"2022042606521554400_ref10","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00464-006-0108-2","article-title":"Effect of partial and total laparoscopic fundoplication on esophageal body motility","volume":"21","author":"Herbella","year":"2007","journal-title":"Surg Endosc"},{"issue":"2","key":"2022042606521554400_ref11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4292\/wjgpt.v5.i2.86","article-title":"Esophageal motility abnormalities in gastroesophageal reflux disease","volume":"5","author":"Martinucci","year":"2014","journal-title":"World J Gastrointest Pharmacol Ther"},{"issue":"9","key":"2022042606521554400_ref12","doi-asserted-by":"crossref","first-page":"e13584","DOI":"10.1111\/nmo.13584","article-title":"Ineffective esophageal motility: concepts, future directions, and conclusions from the Stanford 2018 symposium","volume":"31","author":"Gyawali","year":"2019","journal-title":"Neurogastroenterol Motil"},{"issue":"11","key":"2022042606521554400_ref13","doi-asserted-by":"crossref","first-page":"e13870","DOI":"10.1111\/nmo.13870","article-title":"Jackhammer esophagus: a meta-analysis of patient demographics, disease presentation, high-resolution manometry data, and treatment outcomes","volume":"32","author":"Wahba","year":"2020","journal-title":"Neurogastroenterol Motil"}],"container-title":["Diseases of the 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