{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:56:05Z","timestamp":1787169365520,"version":"build-2736575974"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32 DK007634"],"award-info":[{"award-number":["T32 DK007634"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T35 DK007386"],"award-info":[{"award-number":["T35 DK007386"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Eosinophilic esophagitis (EoE) has been associated with autoimmune (AI) and connective tissue disorders (CTDs), but clinical correlates and treatment response to topical corticosteroids (tCS) for patients with both conditions are not well known. We aimed to determine the prevalence and clinical features of AI\/CTDs in EoE patients, and assess the response to tCS. In this retrospective cohort study of adults and children newly diagnosed with EoE in the University of North Carolina EoE Clinicopathologic database, we extracted clinical characteristics and treatment response data. We compared EoE patients with and without AI\/CTDs, identified independently associated factors, and explored treatment responses. Of 1029 EoE patients, 61 (5.9%) had an AI\/CTDs. The most common AI\/CTDs were psoriasis\/psoriatic arthritis (P\/PA) (1.7%), Hashimoto\u2019s (1.2%), and rheumatoid arthritis (RA) (1%). Compared to those without AI\/CTDs, AI\/CTDs patients were older (35 vs. 28\u00a0years, P\u2009=\u20090.004), more likely to be female (51% vs. 30%, P\u2009=\u20090.001), have insurance (93% vs. 78%, P\u2009=\u20090.004) and a longer symptom duration prior to EoE diagnosis (10 vs. 7\u00a0years, P\u2009=\u20090.02). Older age, female sex, having insurance, and having allergic rhinitis were independently associated with AI\/CTDs. AI\/CTD patients with EoE were less likely to have a symptom response (47% vs. 79%, P\u2009=\u20090.003). Overlap between EoE and AI\/CTDs was uncommon, seen in approximately 6%, with P\/PA, Hashimoto\u2019s, and RA being most frequent. In conclusion, older age, female sex, having insurance, and allergic rhinitis were independently associated with AI\/CTDs. EoE patients with AI\/CTDs had less symptom response, with trendtowards lower endoscopic and histologic responses, to tCS therapy.<\/jats:p>","DOI":"10.1093\/dote\/doac043","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T09:56:25Z","timestamp":1657706185000},"source":"Crossref","is-referenced-by-count":23,"title":["Association of eosinophilic esophagitis with autoimmune and connective tissue disorders, and the impact on treatment response"],"prefix":"10.1093","volume":"36","author":[{"given":"Zeyun","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Medicine , Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talya L","family":"Miller","sequence":"additional","affiliation":[{"name":"Swedish Digestive Health Institute , Swedish Health, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Abramson","sequence":"additional","affiliation":[{"name":"Department of Medicine , Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kisan P","family":"Thakkar","sequence":"additional","affiliation":[{"name":"Department of Medicine , Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey J","family":"Ketchem","sequence":"additional","affiliation":[{"name":"Department of Medicine , Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, 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