{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:21:27Z","timestamp":1788844887419,"version":"build-2803163510"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T00:00:00Z","timestamp":1658016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Key Project of the Ministry of Science and Technology of China","award":["2106YFC0103702"],"award-info":[{"award-number":["2106YFC0103702"]}]},{"name":"Key Research Program of the Chinese Academy of Sciences","award":["KGZD-EW-T03"],"award-info":[{"award-number":["KGZD-EW-T03"]}]},{"name":"Capital Characteristic Clinic Project","award":["Z181100001718190"],"award-info":[{"award-number":["Z181100001718190"]}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z201100006820017"],"award-info":[{"award-number":["Z201100006820017"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z19111000110000"],"award-info":[{"award-number":["Z19111000110000"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Peking University People\u2019s Hospital Research and Development Foundation","award":["RDC2020-33"],"award-info":[{"award-number":["RDC2020-33"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,28]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Chylothorax is a serious complication after esophagectomy and there are unmet needs for new intraoperative navigation tools to reduce its incidence. The aim of this study is to explore the feasibility and effectiveness of near-infrared fluorescence imaging (NIR-FI) with indocyanine green (ICG) to identify thoracic ducts (TDs) and chyle leakage during video-assisted thoracoscopic esophagectomy. We recruited 41 patients who underwent thoraco-laparoscopic minimally invasive esophagectomy (MIE) for esophageal cancer in this prospective, open-label, single-arm clinical trial. ICG was injected into the right inguinal region before operations, after which TD anatomy and potential chyle leakage were checked under the near-infrared fluorescence intraoperatively. In 38 of 41 patients (92.7%) using NIR-FI, TDs were visible in high contrast. The mean signal-to-background ratio (SBR) value of all fluorescent TDs was 3.05\u2009\u00b1\u20091.56. Fluorescence imaging of TDs could be detected 0.5\u00a0hours after ICG injection and last up to 3\u00a0hours with an acceptable SBR value. The optimal observation time window is from about 1 to 2 hours after ICG injection. Under the guidance of real-time NIR-FI, three patients were found to have chylous leakage and the selective TD ligations were performed intraoperatively. No patient had postoperative chylothorax. NIR-FI with ICG can provide highly sensitive and real-time assessment of TDs as well as determine the source of chyle leakage, which might help reduce TD injury and direct selective TD ligation. It could be a promising navigation tool to reduce the incidence of chylothorax after minimally invasive esophagectomy.<\/jats:p>","DOI":"10.1093\/dote\/doac049","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T15:11:48Z","timestamp":1658157108000},"source":"Crossref","is-referenced-by-count":18,"title":["Near-infrared fluorescence imaging of thoracic duct in minimally invasive esophagectomy"],"prefix":"10.1093","volume":"36","author":[{"given":"Feng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery , Center of Thoracic Mini-invasive Surgery, , Beijing , China"},{"name":"Peking University People\u2019s Hospital , Center of Thoracic Mini-invasive Surgery, , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery , Center of Thoracic Mini-invasive Surgery, , Beijing , 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Laboratory of Management and Control for Complex Systems, Institute of Automation, , Beijing , China"},{"name":"Chinese Academy of Sciences , the State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, , Beijing , China"},{"name":"State Key Laboratory of Computer Science and Beijing Key Lab of Human-Computer Interaction , Institute of Software, , Beijing , China"},{"name":"Chinese Academy of Sciences , Institute of Software, , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery , Center of Thoracic Mini-invasive Surgery, , Beijing , China"},{"name":"Peking University People\u2019s Hospital , Center of Thoracic Mini-invasive Surgery, , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kezhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery , Center of Thoracic Mini-invasive Surgery, , Beijing , China"},{"name":"Peking University People\u2019s Hospital , Center of Thoracic Mini-invasive Surgery, , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery , Center of Thoracic Mini-invasive Surgery, , Beijing , China"},{"name":"Peking University People\u2019s Hospital , Center of Thoracic Mini-invasive Surgery, , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery , Center of Thoracic Mini-invasive Surgery, , Beijing , China"},{"name":"Peking University People\u2019s Hospital , Center of Thoracic Mini-invasive Surgery, , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Big Data-Based Precision Medicine , School of Medicine and Engineering, , Beijing , China"},{"name":"Beihang University , School of Medicine and Engineering, , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery , Center of Thoracic Mini-invasive Surgery, , Beijing , China"},{"name":"Peking University People\u2019s Hospital , Center of Thoracic Mini-invasive Surgery, , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuli","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery , Center of Thoracic Mini-invasive Surgery, , Beijing , China"},{"name":"Peking University People\u2019s Hospital , Center of Thoracic Mini-invasive Surgery, , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongwei","family":"Chi","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Molecular Imaging , the State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, , Beijing , China"},{"name":"Chinese Academy of Sciences , the State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery , Center of Thoracic Mini-invasive Surgery, , Beijing , China"},{"name":"Peking University People\u2019s Hospital , Center of Thoracic Mini-invasive Surgery, , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic 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