{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:50:13Z","timestamp":1753876213656,"version":"3.41.2"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,24]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Esophageal adenocarcinoma (EAC) develops in a step-wise manner, from low-grade dysplasia (LGD) to high-grade dysplasia (HGD), and ultimately to invasive EAC. However, there remains diagnostic uncertainty about LGD and its risk of progression to HGD\/EAC. The aim is to investigate the role of Ki-67, immune-histochemical marker of proliferation, surface expression in patients with confirmed LGD, and risk stratify progression to HGD\/EAC. A retrospective cohort study was conducted. Patients with confirmed LGD and indefinite for dysplasia (IND), with a mean follow-up of \u22651\u00a0year, were included. Pathology specimens were stained for Ki-67 and analyzed for evidence of surface expression. Our results reveal that 29% of patients with confirmed LGD who stained positive with Ki-67 progressed to HGD\/EAC as opposed to none (0%) of the patients who stained negative, a statistically significant result (P\u2009=\u20090.003). Similarly, specimens from patients with IND were stained and analyzed revealing a nonsignificant trend toward a higher rate of progression for Ki-67 positive cases versus Ki-67 negative, 30% versus 21%, respectively. Ki-67 expression by itself can identify patients with LGD at a high risk of progression.<\/jats:p>","DOI":"10.1093\/dote\/doac065","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T13:29:25Z","timestamp":1664803765000},"source":"Crossref","is-referenced-by-count":0,"title":["A Consensus Diagnosis Utilizing Surface KI-67 Expression as an Ancillary Marker in Low-Grade Dysplasia Helps Identify Patients at High Risk of Progression to High-Grade Dysplasia and Esophageal Adenocarcinoma"],"prefix":"10.1093","volume":"36","author":[{"given":"Christina","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Minnesota , MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umar","family":"Hayat","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University of Minnesota & Veterans Administration Health Care System , Minneapolis, MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastroenterolgoy, Mayo Clinic , Scottsdale, AZ , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy A","family":"Gravely","sequence":"additional","affiliation":[{"name":"Department of Research, Veterans Administration Health Care System , Minneapolis, MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector","family":"Mesa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Indiana University Medical School , Indianapolis, IN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Peltola","sequence":"additional","affiliation":[{"name":"Department of Pathology, Veterans Administration Health Care System , Minneapolis, MN , 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aasma","family":"Shaukat","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, NYU-Lagone School of Medicine , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J","family":"Hanson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University of Minnesota & Veterans Administration Health Care System , Minneapolis, MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"2023071012225798400_ref1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1158\/1055-9965.EPI-16-0520","article-title":"Cancer incidence and survival trends by subtype using data from the Surveillance Epidemiology and End Results Program, 1992-2013","volume":"26","author":"Noone","year":"2017","journal-title":"Cancer Epidemiol 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