{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:36:53Z","timestamp":1780429013632,"version":"3.54.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,30]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Few predictors of response to topical corticosteroid (tCS) treatment have been identified in eosinophilic esophagitis (EoE). We aimed to determine whether baseline gene expression predicts histologic response to tCS treatment for EoE. We analyzed prospectively collected samples from incident EoE cases who were treated with tCS for 8\u00a0weeks in a development cohort (prospective study) or in an independent validation cohort (clinical trial). Whole transcriptome RNA expression was determined from a baseline (pre-treatment) RNA-later preserved esophageal biopsy. Baseline expression was compared between histologic responders (&amp;lt;15 eos\/hpf) and non-responders (\u226515 eos\/hpf), and differential correlation was used to assess baseline gene expression by response status. In 87 EoE cases analyzed in the development set, there were no differentially expressed genes associated with treatment response (at false discovery rate\u2009=\u20090.1). However, differential correlation identified a module of 22 genes with statistically significantly high pairwise correlation in non-responders (mean correlation coefficient\u2009=\u20090.7) compared to low correlation in responders (coefficient\u2009=\u20090.3). When this 22-gene module was applied to the 89 EoE cases in the independent cohort, it was not validated to predict tCS response at the 15 eos\/hpf threshold (mean correlation coefficient\u2009=\u20090.32 in responders and 0.25 in nonresponders). Exploration of other thresholds also did not validate any modules. Though we identified a 22 gene differential correlation module measured pre-treatment that was strongly associated with subsequent histologic response to tCS in EoE, this was not validated in an independent population. Alternative methods to predict steroid response should be explored.<\/jats:p>","DOI":"10.1093\/dote\/doac071","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T10:05:44Z","timestamp":1665569144000},"source":"Crossref","is-referenced-by-count":7,"title":["Pre-treatment differential correlation of gene expression and response to topical steroids in eosinophilic esophagitis"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-1101","authenticated-orcid":false,"given":"Evan S","family":"Dellon","sequence":"first","affiliation":[{"name":"Department of Medicine , Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, , Chapel Hill, NC , USA"},{"name":"University of North Carolina School of Medicine , Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, , Chapel Hill, NC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihsuan S","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina , Chapel Hill, NC , USA"},{"name":"Department of Medicine , Lineberger Comprehensive Cancer Center, , Chapel Hill, NC , USA"},{"name":"University of North Carolina , Lineberger Comprehensive Cancer Center, , Chapel Hill, NC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisha R","family":"Coffey","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina , Chapel Hill, NC , USA"},{"name":"Department of Medicine , Lineberger Comprehensive Cancer Center, , Chapel Hill, NC , USA"},{"name":"University of North Carolina , Lineberger Comprehensive Cancer Center, , Chapel Hill, NC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Bodwin","sequence":"additional","affiliation":[{"name":"Department of Statistics and Operations Research, University of North Carolina , Chapel Hill, NC , USA"},{"name":"Statistics Department, Cal Poly , Obispo, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared A","family":"Sninsky","sequence":"additional","affiliation":[{"name":"Department of Medicine , Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, , Chapel Hill, NC , USA"},{"name":"University of North Carolina School of Medicine , Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, , Chapel Hill, NC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carson N","family":"Mosso","sequence":"additional","affiliation":[{"name":"Department of Statistics and Operations Research, University of North Carolina , Chapel Hill, NC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshe 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