{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T11:29:50Z","timestamp":1763810990783,"version":"3.41.2"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30CA046934"],"award-info":[{"award-number":["P30CA046934"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Endoscopic eradication therapy (EET) is an effective treatment for Barrett\u2019s esophagus (BE); however, disease recurrence remains problematic requiring surveillance post-treatment. While data regarding predictors of recurrence are limited, uncontrolled reflux may play a significant role. Our aim was to develop a scoring system based on histopathologic reflux in surveillance biopsies following EET to identify patients at high risk for recurrence of BE. Patients were identified from two centers in the treatment with resection and endoscopic ablation techniques for BE consortium. Hematoxylin and eosin-stained slides of surveillance biopsies post-EET were assessed for histologic changes associated with reflux from a cohort of patients who also underwent pH-metry (derivation cohort). We developed a novel scoring system (Recurrent Epithelial Changes from Uncontrolled Reflux [RECUR]) composed of dilated intercellular spaces, epithelial ballooning, basal cell hyperplasia, and parakeratosis, to identify patients with abnormal esophageal acid exposure. This scoring system was then used to grade surveillance biopsies from patients with or without recurrence of BE following EET (validation cohort). Of 41 patients in the derivation cohort, 19.5% had abnormal acid exposure times (AET) while on proton pump inhibitor therapy. The mean (SD) RECUR score for patients with AET &amp;lt;4% was 4.0 (1.6), compared with 5.5 (0.9) for AET \u22654% (P = 0.015). In the validation cohort consisting of 72 patients without recurrence and 64 patients with recurrence following EET, the RECUR score was the only significant predictor of recurrence (odds ratio: 1.36, 95% confidence interval: 1.10\u20131.69, P = 0.005). Histologic grading of surveillance biopsies using the RECUR scoring system correlates with BE recurrence following EET.<\/jats:p>","DOI":"10.1093\/dote\/doac078","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T02:40:07Z","timestamp":1669776007000},"source":"Crossref","is-referenced-by-count":1,"title":["Novel histologic score predicts recurrent intestinal metaplasia after successful endoscopic eradication therapy"],"prefix":"10.1093","volume":"36","author":[{"given":"Joseph R","family":"Triggs","sequence":"first","affiliation":[{"name":"Fox Chase Cancer Center Division of Gastroenterology, Department of Medicine, , Philadelphia, PA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina","family":"Krogh","sequence":"additional","affiliation":[{"name":"Northwestern University Department of Pathology, Feinberg School of Medicine, , Chicago, IL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violette","family":"Simon","sequence":"additional","affiliation":[{"name":"University of Colorado Division of Gastroenterology, Department of Medicine, , Denver, CO , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Krause","sequence":"additional","affiliation":[{"name":"Northwestern University Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, , Chicago, IL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey B","family":"Kaplan","sequence":"additional","affiliation":[{"name":"University of Colorado Department of Pathology, , Denver, CO , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Northwestern University Department of Pathology, Feinberg School of Medicine, , Chicago, IL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin","family":"Wani","sequence":"additional","affiliation":[{"name":"University of Colorado Division of Gastroenterology, Department of Medicine, , Denver, CO , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J","family":"Kahrilas","sequence":"additional","affiliation":[{"name":"Northwestern University Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, , Chicago, IL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Pandolfino","sequence":"additional","affiliation":[{"name":"Northwestern University Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, , Chicago, IL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinadh","family":"Komanduri","sequence":"additional","affiliation":[{"name":"Northwestern University Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, , Chicago, IL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"2023050106025763800_ref1","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJMra1314704","article-title":"Barrett's esophagus","volume":"371","author":"Spechler","year":"2014","journal-title":"New Engl J Med"},{"key":"2023050106025763800_ref2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.gie.2007.07.019","article-title":"Incidence of esophageal adenocarcinoma in patients with Barrett's esophagus and high-grade dysplasia: a meta-analysis","volume":"67","author":"Rastogi","year":"2008","journal-title":"Gastrointest Endosc"},{"key":"2023050106025763800_ref3","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1053\/j.gastro.2011.06.055","article-title":"Risk factors for progression of low-grade dysplasia in patients 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