{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:17:59Z","timestamp":1787008679954,"version":"build-2736575974"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Magnetic sphincter augmentation (MSA) was introduced in 2007 as an alternative surgical procedure for patients with gastroesophageal reflux disease (GERD). The majority of data since MSA\u2019s introduction has focused on short and intermediate-term results, demonstrating safety and high efficacy in terms of reflux symptom control, freedom from proton pump inhibitor use and normalization of distal esophageal acid exposure. However, GERD is a chronic condition that demands a long-term solution. Limited available data from studies reporting outcomes at 5\u00a0years or later following MSA demonstrate that the promising short- and mid-term efficacy and safety profile of MSA remains relatively constant in the long term. Compared with Nissen fundoplication, MSA has a much lower rate of gas-bloat and inability to belch at a short-term follow-up, a difference that persists in the long-term. The most common complaint after MSA at a short-term follow-up is dysphagia. However, limited data suggest dysphagia rates largely decrease by 5\u00a0years. Dysphagia is the most common indication for dilation and device removal in both early- and long-term studies. However, the overall rates of dilation and removal are similar in short- and long-term reports, suggesting the majority of these procedures are performed in the short-term period after device implantation. The indications and standard practices of MSA have evolved over time. Long-term outcome data currently available are all from patient cohorts who were selected for MSA under early restricted indications and outdated regimens. Therefore, further long-term studies are needed to corroborate the preliminary, yet encouraging long-term results.<\/jats:p>","DOI":"10.1093\/dote\/doac109","type":"journal-article","created":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T01:11:44Z","timestamp":1672449104000},"source":"Crossref","is-referenced-by-count":4,"title":["Long-term clinical and functional results of magnetic sphincter augmentation"],"prefix":"10.1093","volume":"36","author":[{"given":"Inanc S","family":"Sarici","sequence":"first","affiliation":[{"name":"Esophageal Institute , Department of Surgery, Allegheny Health Network, Pittsburgh, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin P","family":"Dunn","sequence":"additional","affiliation":[{"name":"Esophageal Institute , Department of Surgery, Allegheny Health Network, Pittsburgh, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven E","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Esophageal Institute , Department of Surgery, Allegheny Health Network, Pittsburgh, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair A","family":"Jobe","sequence":"additional","affiliation":[{"name":"Esophageal Institute , Department of Surgery, Allegheny Health Network, Pittsburgh, PA , USA"},{"name":"Drexel University Department of Surgery, , Philadelphia, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8113-9164","authenticated-orcid":false,"given":"Shahin","family":"Ayazi","sequence":"additional","affiliation":[{"name":"Esophageal Institute , Department of Surgery, Allegheny Health Network, Pittsburgh, PA , USA"},{"name":"Drexel University Department of Surgery, , Philadelphia, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"issue":"5","key":"2023062314435351400_ref18","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.surg.2019.04.024","article-title":"Long-term (15-year) objective evaluation of 150 patients after laparoscopic Nissen fundoplication","volume":"166","author":"Csendes","year":"2019","journal-title":"Surgery"},{"issue":"4","key":"2023062314435351400_ref16","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/BF01307574","article-title":"Long-term results of Nissen fundoplication in reflux esophagitis without strictures. Clinical, endoscopic, and pH-metric evaluation","volume":"37","author":"Martinez de Haro","year":"1992","journal-title":"Dig Dis Sci"},{"issue":"7","key":"2023062314435351400_ref20","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1007\/s00464-020-07792-1","article-title":"Three-year clinical experience with magnetic sphincter augmentation and laparoscopic fundoplication","volume":"35","author":"Bonavina","year":"2021","journal-title":"Surg Endosc"},{"issue":"11","key":"2023062314435351400_ref24","doi-asserted-by":"crossref","DOI":"10.1093\/dote\/doab036","article-title":"Evolution of a novel technology for gastroesophageal reflux disease: a safety perspective of magnetic sphincter augmentation","volume":"34","author":"DeMarchi","year":"2021","journal-title":"Dis Esophagus"},{"issue":"12","key":"2023062314435351400_ref1","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1007\/s11605-008-0698-1","article-title":"Magnetic augmentation of the lower esophageal sphincter: results of a feasibility clinical trial","volume":"12","author":"Bonavina","year":"2008","journal-title":"J Gastrointest Surg"},{"issue":"21","key":"2023062314435351400_ref2","first-page":"2039","article-title":"Esophageal sphincter device for gastroesophageal reflux disease","volume":"368","author":"Ganz","year":"2013","journal-title":"N Engl J Med"},{"issue":"5","key":"2023062314435351400_ref3","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.jamcollsurg.2020.01.026","article-title":"Clinical outcomes and predictors of favorable result after laparoscopic magnetic sphincter augmentation: single-institution experience with more than 500 patients","volume":"230","author":"Ayazi","year":"2020","journal-title":"J Am Coll Surg"},{"issue":"4","key":"2023062314435351400_ref4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jamcollsurg.2013.04.039","article-title":"One hundred consecutive patients treated with magnetic sphincter augmentation for gastroesophageal reflux disease: 6 years of clinical experience from a single center","volume":"217","author":"Bonavina","year":"2013","journal-title":"J Am Coll Surg"},{"issue":"5","key":"2023062314435351400_ref5","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/SLA.0b013e3181fd879b","article-title":"Laparoscopic sphincter augmentation device eliminates reflux symptoms and normalizes esophageal acid exposure: one- and 2-year results of a feasibility trial","volume":"252","author":"Bonavina","year":"2010","journal-title":"Ann Surg"},{"issue":"5","key":"2023062314435351400_ref6","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.cgh.2015.05.028","article-title":"Long-term outcomes of patients receiving a magnetic sphincter augmentation device for gastroesophageal reflux","volume":"14","author":"Ganz","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"10","key":"2023062314435351400_ref7","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1007\/s00464-012-2289-1","article-title":"The LINX\u00ae reflux management system: confirmed safety and efficacy now at 4 years","volume":"26","author":"Lipham","year":"2012","journal-title":"Surg Endosc"},{"issue":"10","key":"2023062314435351400_ref8","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1089\/lap.2015.0394","article-title":"Magnetic sphincter augmentation for gastroesophageal reflux at 5 years: final results of a pilot study show long-term acid reduction and symptom improvement","volume":"25","author":"Saino","year":"2015","journal-title":"J Laparoendosc Adv Surg Tech A"},{"issue":"1","key":"2023062314435351400_ref9","doi-asserted-by":"crossref","first-page":"13753","DOI":"10.1038\/s41598-020-70742-3","article-title":"Six to 12-year outcomes of magnetic sphincter augmentation for gastroesophageal reflux disease","volume":"10","author":"Ferrari","year":"2020","journal-title":"Sci Rep"},{"issue":"3","key":"2023062314435351400_ref10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.bpg.2013.06.005","article-title":"Management of the patient with incomplete response to PPI therapy","volume":"27","author":"Kahrilas","year":"2013","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"1","key":"2023062314435351400_ref11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.gie.2018.07.007","article-title":"Laparoscopic magnetic sphincter augmentation versus double-dose proton pump inhibitors for management of moderate-to-severe regurgitation in GERD: a randomized controlled trial","volume":"89","author":"Bell","year":"2019","journal-title":"Gastrointest Endosc"},{"issue":"1","key":"2023062314435351400_ref12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00000658-198607000-00002","article-title":"Nissen fundoplication for gastroesophageal reflux disease. Evaluation of primary repair in 100 consecutive patients","volume":"204","author":"DeMeester","year":"1986","journal-title":"Ann Surg"},{"issue":"1","key":"2023062314435351400_ref13","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/bjs.1800800118","article-title":"Outcome 5 years after 360 degree fundoplication for gastro-oesophageal reflux disease","volume":"80","author":"Johansson","year":"1993","journal-title":"Br J Surg"},{"issue":"6","key":"2023062314435351400_ref14","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/bjs.1800830633","article-title":"Long-term results of a prospective randomized comparison of total fundic wrap (Nissen-Rossetti) or semifundoplication (Toupet) for gastro-oesophageal reflux","volume":"83","author":"Lundell","year":"1996","journal-title":"Br J Surg"},{"issue":"8","key":"2023062314435351400_ref15","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1136\/gut.34.8.1015","article-title":"Fate of Nissen fundoplication after 20 years. A clinical, endoscopical, and functional analysis","volume":"34","author":"Luostarinen","year":"1993","journal-title":"Gut"},{"issue":"4","key":"2023062314435351400_ref17","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/bjs.1800810421","article-title":"Value of Nissen fundoplication in patients with gastro-oesophageal reflux judged by long-term symptom control","volume":"81","author":"Grande","year":"1994","journal-title":"Br J Surg"},{"issue":"2","key":"2023062314435351400_ref19","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.athoracsur.2014.04.074","article-title":"Short-term outcomes using magnetic sphincter augmentation versus Nissen fundoplication for medically resistant gastroesophageal reflux disease","volume":"98","author":"Louie","year":"2014","journal-title":"Ann Thorac Surg"},{"issue":"9","key":"2023062314435351400_ref21","doi-asserted-by":"crossref","first-page":"6851","DOI":"10.1007\/s00464-022-09015-1","article-title":"S148: long-term patient-reported outcomes of laparoscopic magnetic sphincter augmentation versus Nissen fundoplication: a 5-year follow-up study","volume":"36","author":"O\u2019Neill","year":"2022","journal-title":"Surg Endosc"},{"issue":"30","key":"2023062314435351400_ref22","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000004366","article-title":"Longitudinal comparison of quality of life in patients undergoing laparoscopic Toupet fundoplication versus magnetic sphincter augmentation: observational cohort study with propensity score analysis","volume":"95","author":"Asti","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"8","key":"2023062314435351400_ref23","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1007\/s11605-018-3775-0","article-title":"Worldwide experience with erosion of the magnetic sphincter augmentation device","volume":"22","author":"Alicuben","year":"2018","journal-title":"J Gastrointest Surg"},{"issue":"4","key":"2023062314435351400_ref25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/dote.12199","article-title":"Safety analysis of first 1000 patients treated with magnetic sphincter augmentation for gastroesophageal reflux disease","volume":"28","author":"Lipham","year":"2015","journal-title":"Dis Esophagus"},{"issue":"6","key":"2023062314435351400_ref26","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1089\/lap.2017.0025","article-title":"Lower esophageal sphincter augmentation for gastroesophageal reflux disease: the safety of a modern implant","volume":"27","author":"Smith","year":"2017","journal-title":"J Laparoendosc Adv Surg Tech A"},{"issue":"1","key":"2023062314435351400_ref27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11605-019-04331-9","article-title":"Magnetic sphincter augmentation and postoperative dysphagia: characterization, clinical risk factors, and management","volume":"24","author":"Ayazi","year":"2020","journal-title":"J Gastrointest Surg"},{"issue":"5","key":"2023062314435351400_ref28","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1097\/SLA.0000000000001785","article-title":"Removal of the magnetic sphincter augmentation device: surgical technique and results of a single-center cohort study","volume":"265","author":"Asti","year":"2017","journal-title":"Ann Surg"},{"issue":"4","key":"2023062314435351400_ref29","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1046\/j.1365-2168.2000.01413.x","article-title":"Belching and bloating: facts and fantasy after antireflux surgery","volume":"87","author":"Tew","year":"2000","journal-title":"Br J Surg"},{"issue":"8","key":"2023062314435351400_ref30","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1007\/s00464-015-4659-y","article-title":"Multi-institutional outcomes using magnetic sphincter augmentation versus Nissen fundoplication for chronic gastroesophageal reflux disease","volume":"30","author":"Warren","year":"2016","journal-title":"Surg Endosc"},{"issue":"5","key":"2023062314435351400_ref31","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1097\/01.XCS.0000893048.02401.ed","article-title":"Gas-bloat syndrome after magnetic sphincter augmentation: incidence, risk factors and impact on surgical outcomes","volume":"235","author":"Eriksson","year":"2022","journal-title":"J Am Coll Surg"},{"issue":"2","key":"2023062314435351400_ref32","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s00464-018-6367-x","article-title":"Regression of intestinal metaplasia following magnetic sphincter augmentation device placement","volume":"33","author":"Alicuben","year":"2019","journal-title":"Surg Endosc"},{"issue":"10","key":"2023062314435351400_ref33","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1007\/s00464-020-08074-6","article-title":"Regression of Barrett\u2019s esophagus after magnetic sphincter augmentation: intermediate-term results","volume":"35","author":"Dunn","year":"2021","journal-title":"Surg Endosc"},{"issue":"7","key":"2023062314435351400_ref34","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1007\/s00464-021-08839-7","article-title":"Loosening the belt on magnetic sphincter augmentation indications: does body mass index matter?","volume":"36","author":"James","year":"2022","journal-title":"Surg Endosc"},{"issue":"10","key":"2023062314435351400_ref35","doi-asserted-by":"crossref","first-page":"5607","DOI":"10.1007\/s00464-020-08063-9","article-title":"Magnetic sphincter augmentation with hiatal hernia repair: long term outcomes","volume":"35","author":"Dunn","year":"2021","journal-title":"Surg Endosc"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/36\/Supplement_1\/doac109\/50685530\/doac109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/36\/Supplement_1\/doac109\/50685530\/doac109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T18:25:14Z","timestamp":1687631114000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article\/doi\/10.1093\/dote\/doac109\/6965898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,30]]},"references-count":35,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2022,12,30]]},"published-print":{"date-parts":[[2023,6,15]]}},"URL":"https:\/\/doi.org\/10.1093\/dote\/doac109","relation":{},"ISSN":["1120-8694","1442-2050"],"issn-type":[{"value":"1120-8694","type":"print"},{"value":"1442-2050","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2022,12,30]]},"article-number":"doac109"}}