{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:14:26Z","timestamp":1791832466391,"version":"4.3.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Region V\u00e4sterbotten, Sweden"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>This study aimed to investigate the significance of Hill classification to predict esophagitis, Barrett\u2019s esophagus, gastroesophageal reflux disease (GERD) symptomatology, and future prescriptions of proton pump inhibitors in clinical practice. A total of 922 patients (546 women and 376 men; mean age 54.3 [SD 18.4] years) who underwent gastroscopy between 2012 and 2015 were analyzed. Patient questionnaire regarding symptoms were compared with endoscopy findings. A medical chart review was done that focused on the prescription of PPIs, additional gastroscopies, and GERD surgery in a 3-year period before the index gastroscopy and in a 6-year period afterward. In patients na\u00efve to PPI prescriptions (n\u00a0=\u2009466), Hill grade III was significantly associated with esophagitis (AOR 2.20; 95% CI 1.00\u20134.84) and\u2009&amp;gt;\u20092 PPI prescriptions 6 year after the index gastroscopy (AOR 1.95; 95% CI 1.01\u20133.75), whereas Hill grade IV was significantly associated with esophagitis (AOR 4.41; 95% CI 1.92\u201310.1), with Barrett\u2019s esophagus (AOR 12.7; 95% CI 1.45\u2013112), with reported heartburn (AOR 2.28; 95% CI 1.10\u20134.74), and with &amp;gt;2 PPI prescriptions (AOR 2.16; 95% CI 1.02\u20134.55). In patients \u2018non-na\u00efve\u2019 to PPI prescription (n\u00a0=\u2009556), only Hill grade IV was significantly associated with esophagitis, reported heartburn, and with &amp;gt;2 PPI prescriptions. The gastroscopic classification in Hill grades III and IV is important in clinical practice because they are associated with esophagitis, Barrett\u2019s esophagus, symptoms of GERD, and prescriptions of PPIs, whereas a differentiation between Hill grades I and II is not.<\/jats:p>","DOI":"10.1093\/dote\/doad004","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T15:41:28Z","timestamp":1675698088000},"source":"Crossref","is-referenced-by-count":15,"title":["What is the significance of the Hill classification?"],"prefix":"10.1093","volume":"36","author":[{"given":"Lisa","family":"Br\u00e4nnstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Public Health and Clinical Medicine , Medicine, , Ume\u00e5 , Sweden"},{"name":"Ume\u00e5 University , Medicine, , Ume\u00e5 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e5rten","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine , Medicine, , Ume\u00e5 , Sweden"},{"name":"Ume\u00e5 University , Medicine, , Ume\u00e5 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Wallner","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences , Surgery, , Ume\u00e5 , Sweden"},{"name":"Ume\u00e5 University , Surgery, , Ume\u00e5 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl A","family":"Franklin","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences , Surgery, , Ume\u00e5 , Sweden"},{"name":"Ume\u00e5 University , Surgery, , Ume\u00e5 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pontus","family":"Karling","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine , Medicine, , Ume\u00e5 , Sweden"},{"name":"Ume\u00e5 University , Medicine, , Ume\u00e5 , 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