{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:47:42Z","timestamp":1790182062608,"version":"4.1.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Cannabis use is becoming increasingly common, both for recreational and medical purposes. However, there is a paucity of data regarding cannabis use in the context of eosinophilic esophagitis (EoE). We aimed to determine the impact of cannabis use on presentation and treatment response in EoE. To this end, we conducted a retrospective cohort study at a large academic medical center of newly diagnosed EoE patients age\u2009\u2265\u200912\u00a0years. Self-reported cannabis use status, baseline characteristics, and treatment response to topical corticosteroids and dietary therapy data were extracted. Bivariate and multivariable analyses were used to compare cannabis users and non-users at time of EoE diagnosis and to assess treatment response. Of 983 EoE patients, 80 reported using cannabis, with the majority reporting daily use and administration by inhalation. Baseline symptoms and peak eosinophil count were similar between cannabis users and non-users; cannabis users were less likely to have baseline endoscopic findings of exudates, edema, and stricture, and lower total Endoscopic Reference Score. On multivariable analysis, younger age, male sex, non-White race, and psychiatric diagnosis were independently associated with history of cannabis use at EoE presentation and stricture was independently associated with cannabis non-use. Post-treatment symptom and histologic responses were similar between cannabis users and non-users though there was a higher odds of post-treatment endoscopic inflammatory features with cannabis use. In conclusion, despite presenting with milder initial endoscopic findings, cannabis users exhibited greater inflammatory findings after treatment, highlighting a potential negative influence of cannabis use on EoE management.<\/jats:p>","DOI":"10.1093\/dote\/doae080","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T15:21:20Z","timestamp":1727882480000},"source":"Crossref","is-referenced-by-count":4,"title":["Impact of cannabis use on presentation and treatment response in eosinophilic esophagitis"],"prefix":"10.1093","volume":"38","author":[{"given":"Stephanie A","family":"Borinsky","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology , Department of Pediatrics, , Chapel Hill, NC,","place":["USA"]},{"name":"University of North Carolina School of Medicine , Department of Pediatrics, , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra A","family":"Weir","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean S","family":"LaFata","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy S","family":"Gee","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah L","family":"Thel","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenderia A","family":"Cameron","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Z","family":"Xue","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshatha","family":"Kiran","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo A","family":"Ocampo","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"McCallen","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walker D","family":"Redd","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor S","family":"Barlowe","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayan N","family":"Kaakati","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, University of North Carolina School of Medicine , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cary C","family":"Cotton","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swathi","family":"Eluri","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology , Mayo Clinic, Jacksonville, FL,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig C","family":"Reed","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan S","family":"Dellon","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine , Chapel Hill, NC,","place":["USA"]},{"name":"Center for Gastrointestinal Biology and Disease , Division of Gastroenterology and Hepatology, Department of Medicine, , Chapel Hill, NC,","place":["USA"]},{"name":"University of North Carolina School of Medicine , Division of Gastroenterology and Hepatology, Department of Medicine, , Chapel Hill, NC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"2026032303573450100_ref1","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1053\/j.gastro.2018.07.009","article-title":"Updated international consensus diagnostic criteria for eosinophilic esophagitis: proceedings of the AGREE conference","volume":"155","author":"Dellon","year":"2018","journal-title":"Gastroenterology"},{"key":"2026032303573450100_ref2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.cgh.2017.06.036","article-title":"Health-related quality of life and costs associated with eosinophilic esophagitis: a systematic review","volume":"16","author":"Mukkada","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026032303573450100_ref3","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/apt.15231","article-title":"Systematic review with meta-analysis: the growing 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eosinophilic esophagitis","volume":"130","author":"Nhu","year":"2023","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2026032303573450100_ref7","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1016\/j.cgh.2023.07.031","article-title":"Cannabinoids and the gastrointestinal tract","volume":"21","author":"Camilleri","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026032303573450100_ref8","doi-asserted-by":"crossref","first-page":"e030178","DOI":"10.1161\/JAHA.123.030178","article-title":"Association of cannabis use with cardiovascular outcomes among US adults","volume":"13","author":"Jeffers","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"2026032303573450100_ref9","doi-asserted-by":"crossref","first-page":"e13370","DOI":"10.1111\/nmo.13370","article-title":"Cannabinoids and gastrointestinal motility: pharmacology, clinical effects, and potential therapeutics in 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Nutr"},{"key":"2026032303573450100_ref13","doi-asserted-by":"crossref","first-page":"853","DOI":"10.14309\/ajg.0000000000000597","article-title":"Psychiatric comorbidities and psychiatric medication use are highly prevalent in patients with eosinophilic esophagitis and associate with clinical presentation","volume":"115","author":"Reed","year":"2020","journal-title":"Am J Gastroenterol"},{"key":"2026032303573450100_ref14","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s10620-023-08165-z","article-title":"Increasing age at the time of diagnosis and evolving phenotypes of eosinophilic esophagitis over 20 years","volume":"69","author":"Kiran","year":"2024","journal-title":"Dig Dis Sci"},{"key":"2026032303573450100_ref15","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.cgh.2009.08.030","article-title":"Clinical, endoscopic, and histologic findings distinguish eosinophilic esophagitis from gastroesophageal reflux 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