{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:01:37Z","timestamp":1791284497809,"version":"4.1.0"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Peroral plication of the esophagus (POPE) can reduce sump size and improve symptoms in end-stage achalasia. However, its long-term efficacy and safety are unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with end-stage achalasia who underwent POPE at our institution (2016\u20132024) were identified. Data were abstracted for patient demographics, procedural details, and clinical and radiographic outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twelve patients underwent POPE. The technical success rate was 100%, with mean procedural time of 57\u00a0minutes and without adverse events. Symptomatic improvement occurred in 75% of patients (mean follow-up of 15\u00a0months), while 86% had radiographic improvement in sump size. Repeat POPE in 6 (50%) patients a mean of 2.6\u00a0years after index POPE and a third POPE in four (33%) patients a mean of 3.1\u00a0years later was performed, with similar technical success rates and outcomes to the index POPE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>POPE is a safe and repeatable long-term therapeutic option in end-stage achalasia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/dote\/doaf013","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T17:40:36Z","timestamp":1743442836000},"source":"Crossref","is-referenced-by-count":12,"title":["Peroral plication of the esophagus as a treatment option for end-stage achalasia with sump formation"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4892-0378","authenticated-orcid":false,"given":"Ryan G","family":"Alexander","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis M","family":"Wong Kee Song","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash K","family":"Nehra","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A","family":"Alexander","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don C","family":"Codipilly","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanda H","family":"Blackmon","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Baylor College of Medicine , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Ravi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"issue":"2","key":"2025032921331801200_ref1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/nmo.12477","article-title":"The Chicago classification of esophageal motility disorders, v3.0","volume":"27","author":"Kahrilas","year":"2015","journal-title":"Neurogastroenterol Motil"},{"key":"2025032921331801200_ref2","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1007\/s11605-009-1013-5","article-title":"A controversy that has been tough to swallow: is the treatment of achalasia now digested?","volume":"14","author":"Roll","year":"2010","journal-title":"J Gastrointest Surg"},{"issue":"11","key":"2025032921331801200_ref3","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.vgie.2017.07.008","article-title":"Endoscopic esophagoplasty for megaesophagus with sump stasis in end-stage achalasia","volume":"2","author":"Bazerbachi","year":"2017","journal-title":"VideoGIE"},{"issue":"8","key":"2025032921331801200_ref4","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s11605-021-05205-9","article-title":"Per-oral plication of (neo)Esophagus: technical feasibility and early outcomes","volume":"27","author":"Hedberg","year":"2023","journal-title":"J Gastrointest Surg"},{"issue":"9","key":"2025032921331801200_ref5","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1007\/s00464-024-11062-9","article-title":"Efficacy and outcomes of per oral plication of the (neo)esophagus (POPE) for impaired emptying in achalasia and post-esophagectomy patients","volume":"38","author":"Crafts","year":"2024","journal-title":"Surg Endosc"},{"issue":"1","key":"2025032921331801200_ref6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.athoracsur.2016.04.055","article-title":"Predictors of major morbidity or mortality after resection for Esophageal cancer: a Society of Thoracic Surgeons general thoracic surgery database risk adjustment model","volume":"102","author":"Raymond","year":"2016","journal-title":"Ann Thorac Surg"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/38\/2\/doaf013\/62802218\/doaf013.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/38\/2\/doaf013\/62802218\/doaf013.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T17:40:49Z","timestamp":1743442849000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article\/doi\/10.1093\/dote\/doaf013\/8099485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,3]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3,3]]}},"URL":"https:\/\/doi.org\/10.1093\/dote\/doaf013","relation":{},"ISSN":["1120-8694","1442-2050"],"issn-type":[{"value":"1120-8694","type":"print"},{"value":"1442-2050","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2025,3,3]]},"article-number":"doaf013"}}