{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:34:14Z","timestamp":1771331654898,"version":"3.50.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u00a0<\/jats:title>\n                  <jats:p>According to the European Society for Paediatric Gastroenterology Hepatology And Nutrition &amp; North American Society For Pediatric Gastroenterology, Hepatology And Nutrition (ESPGHAN-NASPGHAN) guideline, esophageal atresia (EA) patients should routinely undergo esophagogastroduodenoscopy (EGD) with biopsies and\/or pH-impedance (pH multichannel intraluminal impedance test; pH-MII) for surveillance purposes. It is additionally recommended to perform these procedures when there is a clinical indication: symptoms suggestive of gastroesophageal reflux disease or eosinophilic esophagitis. The aim of this study was to evaluate how often EGD\/pH-MII outcomes change management decisions in EA children who come for surveillance and\/or for clinical evaluation of their symptoms. A retrospective chart review was conducted of all EA patients who received EGD and\/or pH-MII for routine surveillance or because of clinical indication, i.e. symptoms suggestive of gastroesophageal reflux disease or eosinophilic esophagitis. For each procedure, we assessed whether outcomes changed management decisions. Between 2017 and 2020, 41 patients (median age 2.0 [1.0\u201317.5] years) underwent EGD\/pH-MII for surveillance purposes and 64 (3.0 [0.1\u201315.8] years) for symptom evaluation. Of the 41 patients who underwent surveillance EGD\/pH-MII, 18 (43.9%) were asymptomatic when interviewed. Eight of these 18 (44.4%) had results that changed management decisions. In total, 23\/41 (56.1%) had results that changed management decisions. Sixty-four patients presented clinically with (a combination of) dysphagia (n\u2009=\u200950; 78.1%), regurgitation (n\u2009=\u200937; 57.8%), heartburn (n\u2009=\u200918; 28.1%), and\/or respiratory symptoms that were thought to have a gastrointestinal origin (n\u2009=\u200924; 37.5%). Results changed management decisions in 34\/64 (53.1%) patients who presented with symptoms. There is a high clinical yield of EGD and pH-MII testing in EA patients. More than half of the patients, regardless of indication (routine surveillance or symptom evaluation), had EGD and\/or pH-MII results that changed management decisions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>What is known<\/jats:title>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>What is new<\/jats:title>\n               <\/jats:sec>","DOI":"10.1093\/dote\/doaf022","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T20:20:53Z","timestamp":1741724453000},"source":"Crossref","is-referenced-by-count":2,"title":["Clinical yield of esophagogastroduodenoscopy and pH-impedance testing in esophageal atresia patients performed according to international guidelines"],"prefix":"10.1093","volume":"38","author":[{"given":"M","family":"van Lennep","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, Emma Children\u2019s Hospital Amsterdam University Medical Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7895-5331","authenticated-orcid":false,"given":"C","family":"Mussies","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, Emma Children\u2019s Hospital Amsterdam University Medical Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Benninga","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, Emma Children\u2019s Hospital Amsterdam University Medical Center , Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam Gastroenterology and Metabolism Research Institute , Amsterdam ,","place":["The Netherlands"]},{"name":"Special Interest Group for Neurogastroenterology, Motility and Gut-Brain Interaction, European Society for Paediatric Gastroenterology, Hepatology and Nutrition , Geneva ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R R","family":"Gorter","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Emma Children\u2019s Hospital Amsterdam University Medical Center , Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam Gastroenterology and Metabolism Research Institute , Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam Reproduction and Development Research Institute , Amsterdam ,","place":["The Netherlands"]},{"name":"Esophageal Atresia Follow Me Multidisciplinary Program, Emma Children\u2019s Hospital, Amsterdam University Medical Center, location University of Amsterdam , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Sydney Children\u2019s Hospital , Sydney ,","place":["Australia"]},{"name":"School of Women\u2019s and Children\u2019s Health, University of New South Wales , Sydney ,","place":["Australia"]},{"name":"Esophageal Atresia Special Interest Group, European Society for Paediatric Gastroenterology, Hepatology and Nutrition , Geneva ,","place":["Switzerland"]},{"name":"Special Interest Group for Neurogastroenterology, Motility and Gut-Brain Interaction, European Society for Paediatric Gastroenterology, Hepatology and Nutrition , Geneva ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M P","family":"van Wijk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, Emma Children\u2019s Hospital Amsterdam University Medical Center , Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam Gastroenterology and Metabolism Research Institute , Amsterdam ,","place":["The Netherlands"]},{"name":"Esophageal Atresia Follow Me Multidisciplinary Program, Emma Children\u2019s Hospital, Amsterdam University Medical Center, location University of Amsterdam , Amsterdam ,","place":["The Netherlands"]},{"name":"Esophageal Atresia Special Interest Group, European Society for Paediatric Gastroenterology, Hepatology and Nutrition , Geneva ,","place":["Switzerland"]},{"name":"Special Interest Group for Neurogastroenterology, Motility and Gut-Brain Interaction, European Society for Paediatric Gastroenterology, Hepatology and Nutrition , Geneva ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"2025041507264365500_ref1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1136\/archdischild-2011-300597","article-title":"Oesophageal atresia: prevalence, prenatal diagnosis and associated anomalies in 23 European regions","volume":"97","author":"Pedersen","year":"2012","journal-title":"Arch Dis 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esophageal atresia","volume":"29","author":"Petit","year":"2019","journal-title":"Eur J Pediatr Surg"},{"key":"2025041507264365500_ref40","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/MPG.0000000000002336","article-title":"Esophagitis in pediatric esophageal atresia: acid may not always be the issue","volume":"69","author":"Yasuda","year":"2019","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2025041507264365500_ref41","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jpeds.2019.03.015","article-title":"Is there a role for pH impedance monitoring in identifying eosinophilic esophagitis in children with esophageal atresia?","volume":"210","author":"Pesce","year":"2019","journal-title":"J Pediatr"}],"container-title":["Diseases of the 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