{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:01:37Z","timestamp":1791842497958,"version":"4.3.4"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u00a0<\/jats:title>\n                  <jats:p>The Lyon Consensus defines pathological gastroesophageal reflux disease (GERD) as an acid exposure time (AET) greater than 6%, while AET less than 4% rules it out. AET between 4% and 6% is borderline. Prolonged wireless capsule pH monitoring may enhance GERD diagnosis, though it is not widely used in Latin America. This study aimed to categorize patients with borderline AET as GERD or non-GERD using prolonged wireless capsule pH monitoring, assess treatment response, and compare tolerance and interference with 24-hour impedance testing. Thirty-three patients with persistent reflux symptoms and borderline AET (4%\u20136%) from a 24-hour impedance study were included. Exclusions were prior esophageal surgery, major motility disorders, or unreliable impedance tests. A 96-hour off-proton pump inhibitor (PPI) wireless capsule pH monitoring was performed. Patients were categorized as GERD (AET &amp;gt;6% for 2+ days) or non-GERD (AET &amp;lt;4% for 4\u00a0days). Treatment was based on these categories, and GerdQ scores were assessed at baseline and 8\u00a0weeks. Three patients were excluded due to incomplete data. Of the 30 patients, 16 (53%) were classified as GERD, 6 (20%) as non-GERD, and 8 (27%) remained borderline. Wireless capsule monitoring provided a diagnosis in 73% of borderline cases. GERD patients responded well to PPI optimization, while non-GERD patients benefited from neuromodulation. Tolerance and daily activity interference were better with wireless capsule monitoring. Prolonged wireless capsule pH monitoring effectively categorized over 70% of borderline AET patients, leading to improved treatment outcomes with good patient tolerance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key points<\/jats:title>\n               <\/jats:sec>","DOI":"10.1093\/dote\/doaf030","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T04:32:53Z","timestamp":1745641973000},"source":"Crossref","is-referenced-by-count":4,"title":["Prolonged wireless pH monitoring increases diagnostic yield in patients with reflux symptoms and borderline 24-hour impedance pH"],"prefix":"10.1093","volume":"38","author":[{"given":"Harumi","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Hospital de Cl\u00ednicas Jos\u00e9 de San Martin, Sector Neurogastroenterolog\u00eda del Servicio de Gastroenterolog\u00eda , Universidad de Buenos Aires, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda M","family":"Piskorz","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas Jos\u00e9 de San Martin, Sector Neurogastroenterolog\u00eda del Servicio de Gastroenterolog\u00eda , Universidad de Buenos Aires, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan I","family":"Olmos","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas Jos\u00e9 de San Martin, Servicio de Gastroenterolog\u00eda , Universidad de Buenos Aires, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julieta","family":"Arguero","sequence":"additional","affiliation":[{"name":"Hospital Italiano, Servicio de Gastroenter\u00f3logia , Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Wonaga","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas Jos\u00e9 de San Martin, Servicio de Gastroenterolog\u00eda , Universidad de Buenos Aires, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Guzman","sequence":"additional","affiliation":[{"name":"Hospital San Mart\u00edn de La Plata, Servicio de Gastroenter\u00f3logia , Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban Gonz\u00e1lez","family":"Ballerga","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas Jos\u00e9 de San Martin, Servicio de Gastroenterolog\u00eda , Universidad de Buenos Aires, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A","family":"Olmos","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas Jos\u00e9 de San Martin, Sector Neurogastroenterolog\u00eda del Servicio de Gastroenterolog\u00eda , Universidad de Buenos Aires, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,26]]},"reference":[{"key":"2025042600324498600_ref1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/gutjnl-2012-304269","article-title":"Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review","volume":"63","author":"El-Serag","year":"2014","journal-title":"Gut"},{"key":"2025042600324498600_ref2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1365-2036.2005.02565.x","article-title":"Prevalence, clinical spectrum and atypical symptoms of gastro-oesophageal reflux in Argentina: a nationwide population-based study","volume":"22","author":"Chiocca","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"2025042600324498600_ref3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1136\/gutjnl-2023-330616","article-title":"Updates to the modern diagnosis of GERD: Lyon consensus 2.0","volume":"73","author":"Gyawali","year":"2024","journal-title":"Gut"},{"key":"2025042600324498600_ref4","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1053\/j.gastro.2019.12.014","article-title":"Prevalence of gastroesophageal reflux disease and proton pump inhibitor-refractory symptoms","volume":"158","author":"Delshad","year":"2020","journal-title":"Gastroenterology"},{"key":"2025042600324498600_ref5","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1111\/j.1572-0241.2006.00723.x","article-title":"The burden of gastrointestinal and liver diseases, 2006","volume":"101","author":"Shaheen","year":"2006","journal-title":"Am J 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prolonged pH measurements on the diagnosis of gastroesophageal reflux disease: 4-day wireless pH studies","volume":"102","author":"Scarpulla","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"2025042600324498600_ref10","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1023\/A:1026608804938","article-title":"Effect of ambulatory 24-hour esophageal pH monitoring on reflux-provoking activities","volume":"44","author":"Fass","year":"1999","journal-title":"Dig Dis Sci"},{"key":"2025042600324498600_ref11","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1365-2036.2008.03923.x","article-title":"Patient acceptance and clinical impact of bravo monitoring in patients with previous failed catheter-based studies","volume":"29","author":"Sweis","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"2025042600324498600_ref12","doi-asserted-by":"crossref","first-page":"e14735","DOI":"10.1111\/nmo.14735","article-title":"Latin American consensus on 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Ther"},{"key":"2025042600324498600_ref16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s11894-018-0659-0","article-title":"Wireless 24, 48, and 96 hour or impedance or oropharyngeal prolonged pH monitoring: which test, when, and why for GERD?","volume":"20","author":"Chae","year":"2018","journal-title":"Curr Gastroenterol Rep"},{"key":"2025042600324498600_ref17","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/MCG.0000000000000843","article-title":"Safety and efficacy of wireless pH monitoring in patients suspected of gastroesophageal reflux disease: a systematic review","volume":"51","author":"Kessels","year":"2017","journal-title":"J Clin Gastroenterol"},{"key":"2025042600324498600_ref18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1572-0241.2006.00939.x","article-title":"Wireless esophageal pH monitoring is better tolerated than the catheter-based technique: results from a randomized cross-over 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