{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:17:59Z","timestamp":1787008679985,"version":"build-2736575974"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,5,18]],"date-time":"2025-05-18T00:00:00Z","timestamp":1747526400000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>Paraesophageal hernia repair often includes both gastropexy and fundoplication. The fundoplication may cause persistent side effects, and the necessity of the procedure is uncertain. This study aimed to compare gastropexy with or without fundoplication. A retrospective multicenter study was conducted from three Scandinavian hospitals. Patients, with grade III-IV hiatal hernia, who had a laparoscopic repair with total hernia sack removal, closure of hiatus, gastropexy either with or without Nissen fundoplication were included. Outcomes were per- and postoperative complications, postoperative symptom control, and recurrence. A total of 320 patient cases were included in the study (72 patients with Nissen fundoplication and 248 patients without fundoplication). Baseline variables were comparable between the two groups. We found no difference in perioperative or postoperative events, reflux control or recurrence. Median operation time differed with 49\u00a0minutes (P\u2009&amp;lt;\u20090.001) in patients with fundoplication (Median: 108\u00a0minutes, interquartile range (IQR): 88\u2013131\u00a0minutes) compared to patients without fundoplication (59\u00a0minutes, IQR\u2009=\u200946\u201378\u00a0minutes). We also found an increased risk for second repair in the fundoplication group (OR 4.3, 95% CI 1.4\u201313.3). This study shows no benefits of adding a Nissen fundoplication procedure to anterior gastropexy for paraesophageal hernia repair. It was not superior compared to gastropexy alone in terms of postoperative reflux control or preventing recurrence. In contrast, the fundoplication was associated with a four-fold increase of second repair, but the study design limits firm conclusions on this matter.<\/jats:p>","DOI":"10.1093\/dote\/doaf036","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T07:44:15Z","timestamp":1746431055000},"source":"Crossref","is-referenced-by-count":6,"title":["No advantage of fundoplication in paraesophageal hernia repair: a retrospective multicenter study"],"prefix":"10.1093","volume":"38","author":[{"given":"Lene","family":"\u00d8sterballe","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, University Hospital of Northern Norway , St. Olavsgate 70, 9405 Harstad ,","place":["Norway"]},{"name":"Institute of Clinical Medicine, UiT the Arctic University of Norway , Hansine Hansensvei 18, 9019 Troms\u00f8 ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirik K","family":"Aahlin","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, UiT the Arctic University of Norway , Hansine Hansensvei 18, 9019 Troms\u00f8 ,","place":["Norway"]},{"name":"Department of Gastrointestinal Surgery, University Hospital of Northern Norway , Hansine Hansensvej 67, 9019 Troms\u00f8 ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"Goll","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, UiT the Arctic University of Norway , Hansine Hansensvei 18, 9019 Troms\u00f8 ,","place":["Norway"]},{"name":"Department of Gastroenterology, Division of Internal Medicine, University Hospital of Northern Norway , Hansine Hansensvei 67, 9019 Troms\u00f8 ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Alamili","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Hvidovre Hospital , Ketteg\u00e5rdsalle 36, 2650 Hvidovre, Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per-Even","family":"Storli","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, St. Olavs Hospital, Trondheims University Hospital , Prinsesse Kristinas Gate 3, 7030 Trondheim ,","place":["Norway"]},{"name":"MiDT, Nasjonalt forskningssenter for minnimalt invasivt og billedassistert diagnostikk og behandling, St Olavs Hospital, Trondheims University Hospital , Prinsesse Kristinas Gate 3, 7030 Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads V","family":"Gran","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, St. Olavs Hospital, Trondheims University Hospital , Prinsesse Kristinas Gate 3, 7030 Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie B","family":"Lassen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Hvidovre Hospital , Ketteg\u00e5rdsalle 36, 2650 Hvidovre, Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palle B","family":"Miliam","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Hvidovre Hospital , Ketteg\u00e5rdsalle 36, 2650 Hvidovre, Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim E","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, UiT the Arctic University of Norway , Hansine Hansensvei 18, 9019 Troms\u00f8 ,","place":["Norway"]},{"name":"Department of Gastrointestinal Surgery, University Hospital of Northern Norway , Hansine Hansensvej 67, 9019 Troms\u00f8 ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,18]]},"reference":[{"key":"2025052712491786600_ref1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.5009\/gnl.2011.5.3.267","article-title":"Clinical significance of hiatal hernia","volume":"5","author":"Hyun","year":"2011","journal-title":"Gut Liver"},{"key":"2025052712491786600_ref2","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1007\/s00464-014-3877-z","article-title":"Laparoscopic repair of paraesophageal hernia with anterior gastropexy: a multicenter study","volume":"29","author":"Daigle","year":"2015","journal-title":"Surg Endosc"},{"key":"2025052712491786600_ref3","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/bjs\/znac139","article-title":"Development of the ParaOesophageal hernia SympTom (POST) tool","volume":"109","author":"Puri","year":"2022","journal-title":"Br J 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A meta-analysis and systematic review","volume":"36","author":"Clapp","year":"2022","journal-title":"Surg Endosc"},{"key":"2025052712491786600_ref11","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1177\/000313481307900616","article-title":"The need for fundoplication at the time of laparoscopic paraesophageal hernia repair","volume":"79","author":"Westhuizen","year":"2013","journal-title":"Am Surg"},{"key":"2025052712491786600_ref12","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1007\/s00464-016-4796-y","article-title":"Does the addition of fundoplication to repair the intra-thoracic stomach improve quality of life?","volume":"30","author":"Svetanoff","year":"2016","journal-title":"Surg Endosc"},{"key":"2025052712491786600_ref13","doi-asserted-by":"crossref","first-page":"902","DOI":"10.21037\/atm.2020.03.106","article-title":"Paraesophageal hernia: to fundoplicate or not?","volume":"9","author":"Solomon","year":"2021","journal-title":"Ann Transl Med"},{"key":"2025052712491786600_ref14","doi-asserted-by":"crossref","first-page":"12544","DOI":"10.1038\/s41598-019-48740-x","article-title":"Role of fundoplication in treatment of patients with symptoms of hiatal hernia","volume":"9","author":"Li","year":"2019","journal-title":"Sci Rep"},{"key":"2025052712491786600_ref15","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s00268-010-0814-8","article-title":"Tailored or routine addition of an antireflux fundoplication in laparoscopic large hiatal hernia repair: a comparative cohort study","volume":"35","author":"Furn\u00e9e","year":"2011","journal-title":"World J Surg"},{"key":"2025052712491786600_ref16","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jamcollsurg.2015.03.003","article-title":"Repair of Paraesophageal hiatal hernias\u2014is a fundoplication needed? 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Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/38\/3\/doaf036\/63218282\/doaf036.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/38\/3\/doaf036\/63218282\/doaf036.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T12:49:46Z","timestamp":1748350186000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article\/doi\/10.1093\/dote\/doaf036\/8134376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5,3]]}},"URL":"https:\/\/doi.org\/10.1093\/dote\/doaf036","relation":{},"ISSN":["1120-8694","1442-2050"],"issn-type":[{"value":"1120-8694","type":"print"},{"value":"1442-2050","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,5,3]]},"article-number":"doaf036"}}