{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:58:38Z","timestamp":1788850718513,"version":"build-2803163510"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with poor prognosis, and lymph node metastasis significantly influences patient outcomes. This retrospective study analyzed 189 thoracic ESCC patients who underwent radical esophagectomy (2019\u20132021) to evaluate the prognostic role of recurrent laryngeal nerve lymph node metastasis (RLN LNM). Patients with RLN LNM showed significantly worse overall survival (OS, P\u2009=\u20090.01) and disease-free survival (DFS, P\u2009=\u20090.046) than those without metastasis, with a 50.53% higher mortality risk and 37.83% higher recurrence risk. Subgroup analysis revealed no survival differences between left- and right-sided RLN LNM (P&amp;gt;0.05), while bilateral RLN LNM trended toward poorer outcomes but without statistical significance. Patients with RLN LNM plus extranodal metastases had markedly reduced OS (P\u2009=\u20090.0014) and DFS (P\u2009=\u20090.0008) compared to isolated RLN LNM. RLN LNM significantly predicted poor prognosis in lower thoracic ESCC (OS: P\u2009=\u20090.0027; DFS: P\u2009=\u20090.037) but not in upper or middle thoracic tumors. Multivariate Cox regression identified RLN LNM, perineural invasion, lymphovascular invasion, and neoadjuvant chemoradiotherapy with immunotherapy as independent risk factors for OS. These findings highlight RLN LNM as a critical prognostic indicator, particularly for lower thoracic ESCC, and emphasize the importance of integrating RLN LNM status into treatment strategies and staging systems.<\/jats:p>","DOI":"10.1093\/dote\/doaf052","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T21:04:41Z","timestamp":1751144681000},"source":"Crossref","is-referenced-by-count":2,"title":["Prognostic impact of recurrent laryngeal nerve lymph node metastatic status in thoracic esophageal squamous cell carcinoma"],"prefix":"10.1093","volume":"38","author":[{"given":"Pengjie","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Thoracic Oncology Surgery, Inner Mongolia Hospital of Peking University Cancer Hospital (Affiliated Cancer Hospital of Inner Mongolia Medical University) , Hohhot, Inner Mongolia Autonomous Region ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The Ninth Hospital of Xingtai City , Hebei 054000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlai","family":"Liu","sequence":"additional","affiliation":[{"name":"Endoscopy Center, Inner Mongolia Hospital of Peking University Cancer Hospital (Affiliated Cancer Hospital of Inner Mongolia Medical University) , Hohhot, Inner Mongolia Autonomous Region 010050 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Surgery, Inner Mongolia Hospital of Peking University Cancer Hospital (Affiliated Cancer Hospital of Inner Mongolia Medical University) , Hohhot, Inner Mongolia Autonomous Region ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Inner Mongolia Medical University , Hohhot , Inner Mongolia Autonomous Region 010110,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengfei","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Inner Mongolia Medical University , Hohhot , Inner Mongolia Autonomous Region 010110,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, The Second Hospital of Chifeng , Chifeng City, Inner Mongolia Autonomous Region 024000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bater","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Surgery, Inner Mongolia Hospital of Peking University Cancer Hospital (Affiliated Cancer Hospital of Inner Mongolia Medical University) , Hohhot, Inner Mongolia Autonomous Region ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing 100021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,21]]},"reference":[{"key":"2025062817043782800_ref1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.21147\/j.issn.1000-9604.2021.05.01","article-title":"Esophageal cancer: epidemiology, risk factors and screening","volume":"33","author":"Li","year":"2021","journal-title":"Chin J Cancer Res"},{"key":"2025062817043782800_ref2","doi-asserted-by":"crossref","first-page":"e1022","DOI":"10.1097\/SLA.0000000000003727","article-title":"Prognostic impact of postoperative lymph node metastases after neoadjuvant chemoradiotherapy for locally advanced squamous cell carcinoma of Esophagus: from the results of NEOCRTEC5010, a randomized Multicenter study","volume":"274","author":"Leng","year":"2021","journal-title":"Ann Surg"},{"key":"2025062817043782800_ref3","first-page":"292","article-title":"Clinical study of the pattern of lymphnode metastasis in carcinoma of esophagus: an analysis of 200 cases","volume":"18","author":"Lin","year":"1996","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"2025062817043782800_ref4","first-page":"867","article-title":"Clinical value of Para-recurrent laryngeal nerve lymphadenectomy for middle thoracic esophageal squamous cell carcinoma","volume":"18","author":"Wang","year":"2015","journal-title":"Zhonghua Wei Chang Wai Ke Za Zhi"},{"key":"2025062817043782800_ref5","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.21037\/jgo-21-339","article-title":"Clinical value of lymph node dissection for stage T1b mid-thoracic esophageal squamous cell carcinoma","volume":"12","author":"Chen","year":"2021","journal-title":"J Gastrointest Oncol"},{"key":"2025062817043782800_ref6","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.athoracsur.2013.03.069","article-title":"A strategy for supraclavicular lymph node dissection using recurrent laryngeal nerve lymph node status 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