{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T03:48:49Z","timestamp":1758340129467,"version":"3.44.0"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Despite advances in neonatal surgery and intensive care, esophageal atresia (EA) continues to carry a substantial risk of early postoperative mortality. The aim of this study was to investigate risk factors for 30-day mortality in neonates undergoing surgery for EA. Following approval by our institutional ethics committee, we conducted a retrospective study from January 1, 2010 to December 31, 2024, in a pediatric surgery department. All neonates (\u226428\u00a0days) who underwent primary surgery for EA were included. During the 15-year study period, 113 neonates underwent surgery for EA, with 52.2% being male. Twenty-nine (25.7%) patients died within the first 30 postoperative days. The univariable analysis comparing non-survivors and survivors groups revealed that cardiac comorbidities, gestational age\u2009&amp;lt;\u200937\u00a0weeks, 5-min Apgar score\u2009\u2264\u20098, birth weight\u2009&amp;lt;\u20092500\u00a0g, and postoperative intubation time\u2009&amp;gt;\u200960\u00a0hours were potential risk factors for mortality. On multivariable logistic regression analysis, three factors emerged as independent predictive factors of 30-day mortality. These factors included birth weight\u2009&amp;lt;\u20092500\u00a0g (OR\u2009=\u200966.408; 95% CI: 5.887\u2013749.164; P\u2009=\u20090.001), Apgar score (5\u00a0min)\u2009\u2264\u20098 (OR\u2009=\u200915.213; 95% CI: 3.444\u201367.197; P\u2009&amp;lt;\u20090.001), and cardiac comorbidities (OR\u2009=\u20099.768; 95% CI: 1.626\u201358.665; P\u2009=\u20090.013). Our findings may serve as a valuable tool for the early identification of neonates at increased risk of postoperative mortality, enabling timely risk stratification, optimized perioperative management, and improved decision-making in neonatal surgical care.<\/jats:p>","DOI":"10.1093\/dote\/doaf077","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T23:23:56Z","timestamp":1758324236000},"source":"Crossref","is-referenced-by-count":0,"title":["Risk factors for 30-day mortality in neonates undergoing surgery for esophageal atresia"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9491-816X","authenticated-orcid":false,"given":"Mohamed","family":"Zouari","sequence":"first","affiliation":[{"name":"Research Laboratory \u201cDevelopmental and Induced Diseases\u201d (LR19ES12), Faculty of Medicine of Sfax, University of Sfax , Sfax ,","place":["Tunisia"]},{"name":"Department of Pediatric Surgery, Hedi Chaker Hospital , Sfax ,","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manel","family":"Belhajmansour","sequence":"additional","affiliation":[{"name":"Research Laboratory \u201cDevelopmental and Induced Diseases\u201d (LR19ES12), Faculty of Medicine of Sfax, University of Sfax , Sfax ,","place":["Tunisia"]},{"name":"Department of Pediatric Surgery, Hedi Chaker Hospital , Sfax ,","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manar","family":"Hbaieb","sequence":"additional","affiliation":[{"name":"Research Laboratory \u201cDevelopmental and Induced Diseases\u201d (LR19ES12), Faculty of Medicine of Sfax, University of Sfax , Sfax ,","place":["Tunisia"]},{"name":"Department of Pediatric Surgery, Hedi Chaker Hospital , Sfax ,","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiem","family":"Rhaiem","sequence":"additional","affiliation":[{"name":"Research Laboratory \u201cDevelopmental and Induced Diseases\u201d (LR19ES12), Faculty of Medicine of Sfax, University of Sfax , Sfax ,","place":["Tunisia"]},{"name":"Department of Pediatric Surgery, Hedi Chaker Hospital , Sfax ,","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamdi","family":"Louati","sequence":"additional","affiliation":[{"name":"Research Laboratory \u201cDevelopmental and Induced Diseases\u201d (LR19ES12), Faculty of Medicine of Sfax, University of Sfax , Sfax ,","place":["Tunisia"]},{"name":"Department of Pediatric Surgery, Mohamed Ben Sassi Hospital , Gabes ,","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najoua Ben","family":"Kraiem","sequence":"additional","affiliation":[{"name":"Research Laboratory \u201cDevelopmental and Induced Diseases\u201d (LR19ES12), Faculty of Medicine of Sfax, University of Sfax , Sfax ,","place":["Tunisia"]},{"name":"Department of Pediatric Surgery, Habib Bourguiba Hospital , Medenine ,","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi Ben","family":"Dhaou","sequence":"additional","affiliation":[{"name":"Research Laboratory \u201cDevelopmental and Induced Diseases\u201d (LR19ES12), Faculty of Medicine of Sfax, University of Sfax , Sfax ,","place":["Tunisia"]},{"name":"Department of Pediatric Surgery, Hedi Chaker Hospital , Sfax ,","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riadh","family":"Mhiri","sequence":"additional","affiliation":[{"name":"Research Laboratory \u201cDevelopmental and Induced Diseases\u201d (LR19ES12), Faculty of Medicine of Sfax, University of Sfax , Sfax ,","place":["Tunisia"]},{"name":"Department of Pediatric Surgery, Hedi Chaker Hospital , Sfax ,","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"issue":"6","key":"2025091919235261800_ref1","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.jpedsurg.2022.01.060","article-title":"Current outcomes of infants with esophageal atresia and tracheoesophageal fistula: a multicenter analysis","volume":"57","author":"Keefe","year":"2022","journal-title":"J Pediatr Surg"},{"key":"2025091919235261800_ref2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jpeds.2021.02.064","article-title":"Risk factors of early mortality and morbidity in esophageal atresia with distal tracheoesophageal fistula: a population-based cohort study","volume":"234","author":"Sfeir","year":"2021","journal-title":"J Pediatr"},{"issue":"4","key":"2025091919235261800_ref3","doi-asserted-by":"crossref","first-page":"doac070","DOI":"10.1093\/dote\/doac070","article-title":"Risk factors for adverse outcomes following surgical repair of esophageal atresia. A retrospective cohort study","volume":"36","author":"Zouari","year":"2023","journal-title":"Dis Esophagus"},{"issue":"11","key":"2025091919235261800_ref4","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1111\/ped.14311","article-title":"Esophageal atresia: associated anomalies, mortality, and morbidity in Jordan","volume":"62","author":"Badran","year":"2020","journal-title":"Pediatr Int"},{"issue":"5","key":"2025091919235261800_ref5","doi-asserted-by":"crossref","first-page":"e2020029884","DOI":"10.1542\/peds.2020-029884","article-title":"Survival trends and syndromic esophageal atresia","volume":"147","author":"Tan Tanny","year":"2021","journal-title":"Pediatrics."},{"issue":"6","key":"2025091919235261800_ref6","doi-asserted-by":"crossref","first-page":"728","DOI":"10.4103\/jiaps.jiaps_61_22","article-title":"Technical innovations to reduce complication rates in esophageal atresia with particular reference to long-term outcomes: a single surgeon's experience of 22 years","volume":"27","author":"Morsi","year":"2022","journal-title":"J Indian Assoc Pediatr Surg"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/38\/5\/doaf077\/64302543\/doaf077.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/38\/5\/doaf077\/64302543\/doaf077.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T23:23:57Z","timestamp":1758324237000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article\/doi\/10.1093\/dote\/doaf077\/8256731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":6,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/dote\/doaf077","relation":{},"ISSN":["1120-8694","1442-2050"],"issn-type":[{"type":"print","value":"1120-8694"},{"type":"electronic","value":"1442-2050"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,9,1]]},"article-number":"doaf077"}}