{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T11:05:57Z","timestamp":1763895957645,"version":"3.45.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In esophageal squamous cell carcinoma, three-field lymph node dissection (3FLND) is not commonly performed after neoadjuvant chemoradiotherapy (nCRT) due to the high morbidity associated with the procedure and the poor long-term survival of patients with cervical\/supraclavicular lymph node metastasis. This study aims to evaluate the long-term survival outcomes of patients who underwent 3FLND combined with nCRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between 2013 and 2021, patients who underwent esophagectomy and 3FLND after nCRT for advanced thoracic esophageal squamous cell carcinoma, either with (n\u2009=\u200941) or without (n\u2009=\u200965) clinical cervical\/supraclavicular lymph node metastasis, were included in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Ivor Lewis and McKeown procedures were performed in 22 patients (20.8%) and 84 patients (79.2%), respectively. The rates of major complications (Grade\u2009\u2265\u2009IIIb) and 90-day mortality were 6.6% and 2.8%, respectively. A pathological complete response was observed in 26 patients (24.5%), whereas residual cervical\/supraclavicular lymph node metastasis was identified in 30 patients (28.3%). The five-year overall survival rates for patients with and without preoperative cervical\/supraclavicular lymph node metastasis were 51.5% and 41.4%, respectively. Multivariable analysis of survival in patients with preoperative cervical\/supraclavicular lymph node metastasis identified residual cervical\/supraclavicular lymph node metastasis (hazard ratio [HR]\u2009=\u20097.885, P\u2009&amp;lt;\u20090.001) and major complications (HR\u2009=\u200974.581, P\u2009=\u20090.001) as significant risk factors for overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>3FLND combined with nCRT can achieve favorable long-term survival even in patients with esophageal cancer and cervical\/supraclavicular lymph node metastasis. Downstaging of cervical lymph node metastasis is a key factor in improving survival outcomes for these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/dote\/doaf082","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T13:31:44Z","timestamp":1763731904000},"source":"Crossref","is-referenced-by-count":0,"title":["Three-field lymph node dissection subsequent to neoadjuvant concurrent chemoradiotherapy in esophageal cancer"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3293-1446","authenticated-orcid":false,"given":"Bubse","family":"Na","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine , Seoul , 101 Daehak-ro Jongno-gu Seoul 03080, South Korea,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1612-1937","authenticated-orcid":false,"given":"Chang Hyun","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine , Seoul , 101 Daehak-ro Jongno-gu Seoul 03080, South Korea,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hyeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine , Seoul , 101 Daehak-ro Jongno-gu Seoul 03080, South Korea,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4158-9790","authenticated-orcid":false,"given":"Kwon Joong","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine , Seoul , 101 Daehak-ro Jongno-gu Seoul 03080, South Korea,","place":["Republic of Korea"]},{"name":"Cancer Research Institute, Seoul National University College of Medicine , Seoul , 101 Daehak-ro Jongno-gu Seoul 03080, South Korea,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9625-2672","authenticated-orcid":false,"given":"Samina","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine , Seoul , 101 Daehak-ro Jongno-gu Seoul 03080, South Korea,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3550-5554","authenticated-orcid":false,"given":"In Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine , Seoul , 101 Daehak-ro Jongno-gu Seoul 03080, South Korea,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9006-4881","authenticated-orcid":false,"given":"Young Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine , Seoul , 101 Daehak-ro Jongno-gu Seoul 03080, South Korea,","place":["Republic of Korea"]},{"name":"Cancer Research Institute, Seoul National University College of Medicine , Seoul , 101 Daehak-ro 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