{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T22:06:53Z","timestamp":1771020413868,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Vonoprazan, a potassium competitive acid blocker (P-CAB), shows promise for gastroesophageal reflux disease (GERD). On-demand therapy may reduce costs and drug exposure. This study aimed to compare the efficacy of on-demand versus continuous vonoprazan treatment in the initial management of mild GERD. This observational cohort study enrolled patients with non-erosive reflux disease (NERD) and mild reflux esophagitis (LA grade A\/B). Patients were allocated to either on-demand or continuous vonoprazan (20\u00a0mg\/day) treatment for 4\u00a0weeks. Primary outcomes were changes in Gastroesophageal Reflux Disease Questionnaire (GerdQ) and Gastroesophageal Reflux Disease Health-Related Quality of Life (GERD-HRQL) scores. Secondary outcomes included treatment satisfaction, complete mucosal healing rate, and 24-week relapse rate. The GerdQ score and GERD-HRQL score of the on-demand treatment group decreased significantly after initial treatment compared with the previous one, with statistical significance (P\u2009&amp;lt;\u20090.001). Moreover, there were no significant differences in GerdQ and GERD-HRQL scores between the two groups after the treatment (P\u2009=\u20090.363, P\u2009=\u20090.037; the significance level was P\u2009&amp;lt;\u20090.025). Satisfaction (75.9% vs. 74.3%), complete mucosal healing rates (61.8% vs. 38.8%), and relapse rates (10.2% vs. 8.9%) were comparable in the on-demand and continuous treatment groups. Age (OR\u2009=\u20091.08, 95% CI: 1.05\u20131.11, P\u2009&amp;lt;\u20090.001) and alcohol consumption (OR\u2009=\u20094.31, 95% CI: 1.06\u201317.41, P\u2009=\u20090.04) were influential factors for symptom burden improvement, and treatment allocation (P\u2009=\u20090.069) had no significant effect on symptom burden improvement. Age (OR\u2009=\u20090.94, 95% CI: 0.91\u20130.96, P\u2009&amp;lt;\u20090.001) and pre-treatment Los Angeles grade B (OR\u2009=\u20093.28, 95% CI: 1.46\u20137.34, P\u2009=\u20090.004) were predictors of improved quality of life. This study found on-demand vonoprazan demonstrates comparable efficacy to continuous therapy for mild GERD, offering a cost-effective strategy with minimized drug accumulation risks.<\/jats:p>","DOI":"10.1093\/dote\/doaf092","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T12:06:24Z","timestamp":1759925184000},"source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of different administration methods of vonoprazan for gastroesophageal reflux disease: a retrospective cohort study"],"prefix":"10.1093","volume":"38","author":[{"given":"Qianqian","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Medical Key Laboratory for Diagnosis and Treatment of Colorectal Cancer in Henan Province , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Zhengzhou Key Laboratory for Diagnosis, Treatment and Research of Colorectal Cancer , Zhengzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Medical Key Laboratory for Diagnosis and Treatment of Colorectal Cancer in Henan Province , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Zhengzhou Key Laboratory for Diagnosis, Treatment and Research of Colorectal Cancer , Zhengzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Medical Key Laboratory for Diagnosis and Treatment of Colorectal Cancer in Henan Province , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Zhengzhou Key Laboratory for Diagnosis, Treatment and Research of Colorectal Cancer , Zhengzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Medical Key Laboratory for Diagnosis and Treatment of Colorectal Cancer in Henan Province , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Zhengzhou Key Laboratory for Diagnosis, Treatment and Research of Colorectal Cancer , Zhengzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenting","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Medical Key Laboratory for Diagnosis and Treatment of Colorectal Cancer in Henan Province , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Zhengzhou Key Laboratory for Diagnosis, Treatment and Research of Colorectal Cancer , Zhengzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiale","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Medical Key Laboratory for Diagnosis and Treatment of Colorectal Cancer in Henan Province , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Zhengzhou Key Laboratory for Diagnosis, Treatment and Research of Colorectal Cancer , Zhengzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huili","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Medical Key Laboratory for Diagnosis and Treatment of Colorectal Cancer in Henan Province , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Zhengzhou Key Laboratory for Diagnosis, Treatment and Research of Colorectal Cancer , Zhengzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Medical Key Laboratory for Diagnosis and Treatment of Colorectal Cancer in Henan Province , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Zhengzhou Key Laboratory for Diagnosis, Treatment and Research of Colorectal Cancer , Zhengzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunkun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Medical Key Laboratory for Diagnosis and Treatment of Colorectal Cancer in Henan Province , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Zhengzhou Key Laboratory for Diagnosis, Treatment and Research of Colorectal Cancer , Zhengzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Medical Key Laboratory for Diagnosis and Treatment of Colorectal Cancer in Henan Province , Zhengzhou ,","place":["China"]},{"name":"Department of Gastroenterology, Zhengzhou Key Laboratory for Diagnosis, Treatment and Research of Colorectal Cancer , Zhengzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"2025102907504234700_ref1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S2468-1253(19)30408-X","article-title":"The global, regional, and national burden of gastro-oesophageal reflux disease in 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017","volume":"5","author":"GBD 2017 Gastro-oesophageal Reflux Disease Collaborators","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2025102907504234700_ref2","first-page":"1012","article-title":"Meta-analysis of the prevalence of gastroesophageal reflux disease based on community population in some areas of China","volume":"29","author":"Zhou","year":"2020","journal-title":"Chinese J Gastroenterol Hepatol"},{"key":"2025102907504234700_ref3","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1136\/gutjnl-2020-321365","article-title":"Global prevalence of Barrett\u2019s oesophagus and oesophageal cancer in individuals with gastro-oesophageal reflux: a systematic review and meta-analysis","volume":"70","author":"Eusebi","year":"2021","journal-title":"Gut"},{"key":"2025102907504234700_ref4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.7326\/0003-4819-143-3-200508020-00006","article-title":"Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications","volume":"143","author":"Hampel","year":"2005","journal-title":"Ann Intern Med"},{"key":"2025102907504234700_ref5","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1002\/cpt.2015","article-title":"Clinical pharmacogenetics implementation consortium (CPIC) guideline for CYP2C19 and proton pump inhibitor dosing","volume":"109","author":"Lima","year":"2021","journal-title":"Clin Pharmacol Ther"},{"key":"2025102907504234700_ref6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000542906","article-title":"Severe hypomagnesemia in a patient treated using carboplatin co-administered with vonoprazan","volume":"18","author":"Taniguchi","year":"2025","journal-title":"Case Reports in Oncology"},{"key":"2025102907504234700_ref7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1590\/s0004-2803.202202000-40","article-title":"SAFETY of long-term proton pump inhibitors: facts and myths","volume":"59","author":"Chinzon","year":"2022","journal-title":"Arq Gastroenterol"},{"key":"2025102907504234700_ref8","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1124\/jpet.111.185314","article-title":"Characterization of a novel potassium-competitive acid blocker of the gastric H,K-ATPase, 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438)","volume":"339","author":"Shin","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"2025102907504234700_ref9","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.3390\/jcm10173964","article-title":"Drug-drug interaction between tacrolimus and Vonoprazan in kidney transplant recipients","volume":"10","author":"Suzuki","year":"2021","journal-title":"J Clin Med"},{"key":"2025102907504234700_ref10","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1136\/gutjnl-2019-318365","article-title":"Phase III, randomised, double-blind, multicentre study to evaluate the efficacy and safety of vonoprazan compared with lansoprazole in asian patients with erosive oesophagitis","volume":"69","author":"Xiao","year":"2020","journal-title":"Gut"},{"key":"2025102907504234700_ref11","doi-asserted-by":"crossref","first-page":"e19520","DOI":"10.1097\/MD.0000000000019520","article-title":"Efficacy of vonoprazan for initial and maintenance therapy in reflux esophagitis, nonerosive esophagitis, and proton pump inhibitor-resistant gastroesophageal reflux disease","volume":"99","author":"Gotoh","year":"2020","journal-title":"Medicine"},{"key":"2025102907504234700_ref12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/jgf2.429","article-title":"Treatment strategies for reflux esophagitis including a potassium-competitive acid blocker: a cost-effectiveness analysis in Japan","volume":"22","author":"Habu","year":"2021","journal-title":"J General Family Med"},{"key":"2025102907504234700_ref13","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.cgh.2024.08.004","article-title":"Vonoprazan as a long-term maintenance treatment for erosive esophagitis: VISION, a 5-year, randomized, open-label study","volume":"23","author":"Uemura","year":"2025","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025102907504234700_ref14","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/apt.17728","article-title":"Randomised clinical trial: efficacy and safety of on-demand vonoprazan versus placebo for non-erosive reflux disease","volume":"58","author":"Fass","year":"2023","journal-title":"Aliment Pharmacol Ther"},{"key":"2025102907504234700_ref15","doi-asserted-by":"crossref","first-page":"6417526","DOI":"10.1155\/2018\/6417526","article-title":"On-demand therapy with proton pump inhibitors for maintenance treatment of nonerosive reflux disease or mild erosive esophagitis: a systematic review and meta-analysis","volume":"2018","author":"Khan","year":"2018","journal-title":"Gastroenterol Res Pract"},{"key":"2025102907504234700_ref16","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1136\/gutjnl-2016-313589","article-title":"Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis","volume":"67","author":"Eusebi","year":"2018","journal-title":"Gut"},{"key":"2025102907504234700_ref17","first-page":"200","article-title":"The many faces of cobalamin (vitamin B12) deficiency","volume":"3","author":"Wolffenbuttel","year":"2019","journal-title":"Mayo Clin Proc"},{"key":"2025102907504234700_ref18","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1001\/jama.2020.21360","article-title":"Gastroesophageal reflux disease: a review","volume":"324","author":"Maret-Ouda","year":"2020","journal-title":"JAMA"},{"key":"2025102907504234700_ref19","first-page":"588","article-title":"Gastrointestinal motility group, functional gastrointestinal disease group, Esophageal disease group, Chinese Society of Gastroenterology, Chinese Medical Association. Chinese guidelines for diagnosis and treatment of gastroesophageal reflux disease","volume":"43","year":"2023","journal-title":"Chinese J Digestion"},{"key":"2025102907504234700_ref20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jclinepi.2023.09.014","article-title":"The use of the E-value for sensitivity analysis","volume":"163","author":"Chung","year":"2023","journal-title":"J Clin Epidemiol"},{"key":"2025102907504234700_ref21","first-page":"e64777","article-title":"A comprehensive review on the efficacy and safety of Vonoprazan in the Management of Gastric Acid-Related Diseases","volume":"16","author":"Padwale","year":"2024","journal-title":"Cureus"},{"key":"2025102907504234700_ref22","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1021\/jm300318t","article-title":"Discovery of a novel pyrrole derivative1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB)","volume":"55","author":"Arikawa","year":"2012","journal-title":"J Med Chem"},{"key":"2025102907504234700_ref23","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s10388-024-01099-z","article-title":"Long-term efficacy of on-demand vonoprazan treatment for mild reflux esophagitis: success rates and predictors of treatment failure","volume":"22","author":"Hoshikawa","year":"2025","journal-title":"Esophagus."},{"key":"2025102907504234700_ref24","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1111\/jgh.16486","article-title":"Vonoprazan is superior to lansoprazole for healing of severe but not mild erosive esophagitis: a systematic review with meta-analysis of randomized controlled trials","volume":"39","author":"Simadibrata","year":"2024","journal-title":"J Gastroenterol Hepatol"},{"key":"2025102907504234700_ref25","doi-asserted-by":"crossref","first-page":"2354683","DOI":"10.1080\/07853890.2024.2354683","article-title":"Effect of on-demand vs continuous prescription of proton pump inhibitors on symptom burden and quality of life: results of a real-world randomized controlled trial in primary care patients with gastroesophageal reflux disease","volume":"56","author":"Andreasson","year":"2024","journal-title":"Ann Med"},{"key":"2025102907504234700_ref26","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2169\/internalmedicine.3715-19","article-title":"Vonoprazan-associated gastric mucosal redness: a report of four cases","volume":"59","author":"Kubo","year":"2020","journal-title":"Intern Med"},{"key":"2025102907504234700_ref27","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s12664-023-01384-2","article-title":"Vonoprazan versus lansoprazole in erosive esophagitis - a systematic review and meta-analysis of randomized controlled trials","volume":"42","author":"Chandan","year":"2023","journal-title":"Indian J Gastroenterol"},{"key":"2025102907504234700_ref28","first-page":"527","article-title":"Safety profile of vonoprazan compared with proton pump inhibitors: insight from a pharmacovigilance study","volume":"75","author":"Kambara","year":"2020","journal-title":"Pharmazie"},{"key":"2025102907504234700_ref29","doi-asserted-by":"crossref","first-page":"646","DOI":"10.5009\/gnl20036","article-title":"Proton pump inhibitor-related gastric mucosal changes","volume":"15","author":"Kim","year":"2021","journal-title":"Gut Liver"},{"key":"2025102907504234700_ref30","doi-asserted-by":"crossref","first-page":"6283","DOI":"10.3390\/jcm13206283","article-title":"Approaches to deprescribing proton pump inhibitors in clinical practice: a systematic review","volume":"13","author":"Rossi","year":"2024","journal-title":"J Clin Med"},{"key":"2025102907504234700_ref31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00535-022-01850-2","article-title":"A study for every second day administration of vonoprazan for maintenance treatment of erosive GERD (ESD von GERD): a multicenter randomized cross-over study","volume":"57","author":"Matsuda","year":"2022","journal-title":"J Gastroenterol"},{"key":"2025102907504234700_ref32","first-page":"623","article-title":"Comparison of efficacy of daily and alternate day maintenance treatment of GERD with vonoprazan 10-mg using gastroesophageal reflux disease symptom assessment scale","volume":"40","author":"Rasheed","year":"2024","journal-title":"Pakistan J Med Sci"},{"key":"2025102907504234700_ref33","doi-asserted-by":"crossref","first-page":"460","DOI":"10.5056\/jnm23130","article-title":"On-demand versus continuous maintenance treatment with a proton pump inhibitor for mild gastroesophageal reflux disease: a prospective randomized multicenter study","volume":"29","author":"Jung","year":"2023","journal-title":"J Neurogastroenterol Motility"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/38\/5\/doaf092\/65023672\/doaf092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/38\/5\/doaf092\/65023672\/doaf092.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:50:50Z","timestamp":1761738650000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article\/doi\/10.1093\/dote\/doaf092\/8305685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/dote\/doaf092","relation":{},"ISSN":["1120-8694","1442-2050"],"issn-type":[{"value":"1120-8694","type":"print"},{"value":"1442-2050","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,9,1]]},"article-number":"doaf092"}}