{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:18:02Z","timestamp":1787008682828,"version":"build-2736575974"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Empiric elimination diets remain a cornerstone of treatment for eosinophilic esophagitis (EoE). Immunoglobulin E (IgE) mediated allergic reactions have been sparsely reported during the food reintroduction phase, raising concerns both for patients and physicians. We aimed to assess the physician reported rates of new-onset IgE mediated reactions in EoE associated elimination diets (NIMREEDs), physician awareness of NIMREEDs, and how awareness impacts physician and patient treatment selection. Methods: An international REDCap based questionnaire was distributed via interest groups, gastroenterologist server lists, and professional societies. Physicians were asked about their personal awareness and experience with NIMREEDs and how their knowledge affects physician and patient treatment decisions when contemplating elimination diets (ED) for treatment of EoE. Results: Between January and July 2023, 145 responses were included in this analysis. Of the 12,698 patients with EoE cared for in all responding centers, 4903 (38.6%) had attempted ED. NIMREEDs were reported in 43\/4903 (0.88% [95% CI 0.5\u20131.2%]). Ninety-six (66.2%) physicians were aware of potential reactions, however only 71\/96 (73.9%) discussed them with patients. Knowledge of NIMREEDs deter 17\/96 (17.7%) physicians from recommending ED for EoE, and 15\/71 (21.1%) of those who informed patients, reported reluctance of patients to undertake ED. Conclusion: NIMREEDs following food re-introduction in the treatment of EoE are uncommon, nevertheless they are not widely recognized by physicians. Knowledge concerning NIMREEDs may affect both patient and physician treatment decisions and preferences, as they have potential to negatively affect quality of life, emphasizing the need for increased awareness to NIMREEDs in EoE patients.<\/jats:p>","DOI":"10.1093\/dote\/doaf098","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T18:19:13Z","timestamp":1763576353000},"source":"Crossref","is-referenced-by-count":1,"title":["New-onset IgE mediated reactions in eosinophilic esophagitis associated elimination diets (NIMREEDs)"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1653-8863","authenticated-orcid":false,"given":"Shiri","family":"Cooper","sequence":"first","affiliation":[{"name":"Institute of Gastroenterology Nutrition, and Liver Diseases, Schneider Children\u2019s Medical Center of Israel , Petach Tikva ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luba","family":"Marderfeld","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, The Ottawa Hospital IBD Centre , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raanan","family":"Shamir","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology Nutrition, and Liver Diseases, Schneider Children\u2019s Medical Center of Israel , Petach Tikva ,","place":["Israel"]},{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1970-9143","authenticated-orcid":false,"given":"Noam","family":"Zevit","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology Nutrition, and Liver Diseases, Schneider Children\u2019s Medical Center of Israel , Petach Tikva ,","place":["Israel"]},{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"2025111913190973200_ref1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/2050640616689525","article-title":"Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults","volume":"5","author":"Lucendo","year":"2017","journal-title":"United European Gastroenterol J"},{"key":"2025111913190973200_ref2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/jpn3.12188","article-title":"Diagnosis and management of eosinophilic esophagitis in children: an update from the European Society for Paediatric Gastroenterology, hepatology and nutrition (ESPGHAN)","volume":"79","author":"Amil-Dias","year":"2024","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2025111913190973200_ref3","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1016\/j.cgh.2023.06.005","article-title":"Global incidence and prevalence of eosinophilic esophagitis, 1976-2022: a systematic review and meta-analysis","volume":"21","author":"Hahn","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025111913190973200_ref4","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jaci.2005.01.017","article-title":"Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseases","volume":"115","author":"Simon","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"2025111913190973200_ref5","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1053\/j.gastro.2014.02.006","article-title":"Efficacy of dietary interventions for inducing histologic remission in patients with eosinophilic esophagitis: a systematic review and meta-analysis","volume":"146","author":"Arias","year":"2014","journal-title":"Gastroenterology."},{"key":"2025111913190973200_ref6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.anai.2019.01.010","article-title":"New IgE immediate hypersensitivity reactions on reintroduction of food restricted for treatment of eosinophilic esophagitis","volume":"122","author":"Gottlieb","year":"2019","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2025111913190973200_ref7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jaip.2014.08.005","article-title":"The development of IgE-mediated immediate hypersensitivity after the diagnosis of eosinophilic esophagitis to the same food","volume":"3","author":"Hill","year":"2015","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2025111913190973200_ref8","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.jaip.2017.08.014","article-title":"Development of IgE-mediated immediate hypersensitivity to a previously tolerated food following its avoidance for eosinophilic gastrointestinal diseases","volume":"6","author":"Ho","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2025111913190973200_ref9","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap): a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"2025111913190973200_ref10","doi-asserted-by":"crossref","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: building an international community of software platform partners","volume":"95","author":"Harris","year":"2019","journal-title":"J Biomed Inform"},{"key":"2025111913190973200_ref11","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.jaip.2017.02.021","article-title":"Development of anaphylactic cow\u2019s milk allergy following cow\u2019s milk elimination for eosinophilic esophagitis in a teenager","volume":"5","author":"Soller","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2025111913190973200_ref12","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/ajg.2016.94","article-title":"Anaphylaxis to milk after elimination diet for eosinophilic gastrointestinal disease","volume":"111","author":"Alsalamah","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"2025111913190973200_ref13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jaip.2015.08.006","article-title":"Natural history of food-triggered atopic dermatitis and development of immediate reactions in children","volume":"4","author":"Chang","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2025111913190973200_ref14","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1016\/j.jaip.2022.06.044","article-title":"Dietary elimination for the treatment of atopic dermatitis: a systematic review and meta-analysis","volume":"10","author":"Oykhman","year":"2022","journal-title":"J Allergy Clin Immunol Pract"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/38\/6\/doaf098\/65396954\/doaf098.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/38\/6\/doaf098\/65396954\/doaf098.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T18:19:15Z","timestamp":1763576355000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article\/doi\/10.1093\/dote\/doaf098\/8328285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/dote\/doaf098","relation":{},"ISSN":["1120-8694","1442-2050"],"issn-type":[{"value":"1120-8694","type":"print"},{"value":"1442-2050","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,11,1]]},"article-number":"doaf098"}}