{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:34:16Z","timestamp":1776206056036,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The use of a colonic interposition after major esophageal surgery leads to substantial anatomical changes, but information regarding the effects of these changes on functional outcomes is limited. Objective of this study was to evaluate the presence of gastrointestinal symptoms, nutritional aspects, intestinal absorption capacity, and health-related quality of life (HR-QoL) in adult patients after colon interposition. This single-center study consisted of three parts. Part 1 involved a retrospective review of anthropometric data, dietary patterns, and gastrointestinal symptoms in all consecutive patients who underwent colonic interposition between 2010 and 2021 and in whom at least 6\u00a0months of follow-up were available. Patients from part 1 who were still alive in 2021 were invited for an in-depth evaluation of dietary intake and intestinal absorption capacity. This included measuring daily fecal losses of energy (kcal), fat (g), and protein (g) over a 72-hour period. The coefficients of fat and protein absorption (CFA and CNA) were calculated. Energy balance (kcal\/day) was determined by subtracting fecal energy loss (kcal\/day) and daily estimated total energy expenditure (eTEE) from the dietary energy intake (kcal\/day). Part 3 assessed HR-QoL prospectively using the EORTC QLQ-C30 and OG-25 questionnaires. All consecutive patients presenting to the outpatient clinic between 2014 and 2021 were asked to complete these questionnaires. In part 1 of this study, 30 patients were included. Symptoms of steatorrhea\/diarrhea (65%) and dysphagia (42%) were most frequently reported, and 31% could not cease enteral nutrition via jejunostomy or nasal tube due to weight loss or gastrointestinal symptoms. Ten patients were included in part 2 of this study. Intestinal malabsorption of fat and protein (CFA and CNA &amp;lt;85%) was found in 70% of patients, and 60% of patients had a negative energy balance. HR-QoL was measured in 20 patients. Median global QoL score (EORTC QLQ-C30) was 63 (IQR 50-83) and the OG-25 symptom score 19 (IQR 6.9\u201336). In conclusion a colonic interposition after esophagectomy is accompanied by gastrointestinal symptoms, intestinal malabsorption, and an impaired QoL. Adequate counseling of patients and follow-up with a multidisciplinary approach to treat gastrointestinal symptoms and correct for intestinal malabsorption is recommended.<\/jats:p>","DOI":"10.1093\/dote\/doaf126","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T12:34:55Z","timestamp":1768653295000},"source":"Crossref","is-referenced-by-count":1,"title":["Nutritional aspects and quality of life in gastroesophageal cancer patients that underwent colonic interposition"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3495-3489","authenticated-orcid":false,"given":"L","family":"Blonk","sequence":"first","affiliation":[{"name":"Department of Surgery, Amsterdam UMC location Vrije Universiteit Amsterdam , De Boelelaan 1117, 1081 HV Amsterdam ,","place":["the Netherlands"]},{"name":"Department of Nutrition and Dietetics, Amsterdam UMC location Vrije Universiteit Amsterdam , De Boelelaan 1117, 1081 HV Amsterdam ,","place":["the Netherlands"]},{"name":"Treatment and quality of life, Cancer Center Amsterdam , De Boelelaan 1118, 1081 HZ Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Straatman","sequence":"additional","affiliation":[{"name":"Department of Upper GI surgery, Portsmouth Hospitals University NHS Trust , Southwick Hill Road PO6 3LY Cosham, Portsmouth ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N J","family":"Wierdsma","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Amsterdam UMC location Vrije Universiteit Amsterdam , De Boelelaan 1117, 1081 HV Amsterdam ,","place":["the Netherlands"]},{"name":"Treatment and quality of life, Cancer Center Amsterdam , De Boelelaan 1118, 1081 HZ Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S S","family":"Gisbertz","sequence":"additional","affiliation":[{"name":"Treatment and quality of life, Cancer Center Amsterdam , De Boelelaan 1118, 1081 HZ Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Surgery, Amsterdam UMC location University of Amsterdam , Meibergdreef 9, 1105 AZ Amsterdam ,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D L","family":"van der Peet","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam UMC location Vrije Universiteit Amsterdam , De Boelelaan 1117, 1081 HV Amsterdam ,","place":["the Netherlands"]},{"name":"Treatment and quality of life, Cancer Center Amsterdam , De Boelelaan 1118, 1081 HZ Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Kazemier","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam UMC location Vrije Universiteit Amsterdam , De Boelelaan 1117, 1081 HV Amsterdam ,","place":["the Netherlands"]},{"name":"Treatment and quality of life, Cancer Center Amsterdam , De Boelelaan 1118, 1081 HZ Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8689-3134","authenticated-orcid":false,"given":"M I","family":"van Berge Henegouwen","sequence":"additional","affiliation":[{"name":"Treatment and quality of life, Cancer Center Amsterdam , De Boelelaan 1118, 1081 HZ Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Surgery, Amsterdam UMC location University of Amsterdam , Meibergdreef 9, 1105 AZ Amsterdam ,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"2026020209423902800_ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/dote\/dow003","article-title":"A national audit of colonic interposition for esophageal replacement","volume":"30","author":"Fisher","year":"2017","journal-title":"Dis Esophagus"},{"key":"2026020209423902800_ref2","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.clnu.2015.08.010","article-title":"A systematic review of the nutritional consequences of esophagectomy","volume":"35","author":"Baker","year":"2016","journal-title":"Clin Nutr"},{"key":"2026020209423902800_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doaa022","article-title":"Long-term health-related quality of life after McKeown and Ivor Lewis esophagectomy for esophageal carcinoma","volume":"33","author":"Jezerskyte","year":"2020","journal-title":"Dis Esophagus"},{"key":"2026020209423902800_ref4","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/jso.20132","article-title":"Quality of life after colon interposition by necessity for esophageal cancer replacement","volume":"88","author":"Cense","year":"2004","journal-title":"J Surg Oncol"},{"key":"2026020209423902800_ref5","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1016\/j.athoracsur.2014.06.088","article-title":"Long-term quality of life and alimentary satisfaction after esophagectomy with colon interposition","volume":"98","author":"Greene","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"2026020209423902800_ref6","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1007\/s13304-020-00920-5","article-title":"Colonic interposition, a contemporary experience: technical aspects and outcomes","volume":"73","author":"Fearon","year":"2020","journal-title":"Updates Surg"},{"key":"2026020209423902800_ref7","first-page":"1055","article-title":"Gastrointestinal symptoms after colon interposition","volume":"81","author":"Isolauri","year":"1986","journal-title":"Am J Gastroenterol"},{"key":"2026020209423902800_ref8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clnu.2018.08.002","article-title":"GLIM criteria for the diagnosis of malnutrition - a consensus report from the global clinical nutrition community","volume":"38","author":"Cederholm","year":"2019","journal-title":"Clin Nutr"},{"key":"2026020209423902800_ref9"},{"key":"2026020209423902800_ref10","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s12986-016-0145-3","article-title":"Predicting resting energy expenditure in underweight, normal weight, overweight, and obese adult hospital patients","volume":"13","author":"Kruizenga","year":"2016","journal-title":"Nutr Metab (Lond)"},{"key":"2026020209423902800_ref11","first-page":"37","article-title":"Causes of malabsorption after total gastrectomy with roux-en-Y reconstruction","volume":"154","author":"Armbrecht","year":"1988","journal-title":"Acta Chir Scand"},{"key":"2026020209423902800_ref12","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0009-9120(01)00283-1","article-title":"Comparison of near infrared reflectance analysis of fecal fat, nitrogen and water with conventional methods, and fecal energy content","volume":"35","author":"Neucker","year":"2002","journal-title":"Clin Biochem"},{"key":"2026020209423902800_ref13","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/jhn.12113","article-title":"Bomb calorimetry, the gold standard for assessment of intestinal absorption capacity: normative values in healthy ambulant adults","volume":"27","author":"Wierdsma","year":"2014","journal-title":"J Hum Nutr Diet"},{"key":"2026020209423902800_ref14","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology","volume":"85","author":"Aaronson","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"2026020209423902800_ref15","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doac076","article-title":"The role of fluorescence angiography in colonic interposition after esophagectomy","volume":"36","author":"Joosten","year":"2023","journal-title":"Dis Esophagus"},{"key":"2026020209423902800_ref16","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1093\/ejcts\/ezy398","article-title":"Quality of life of patients with a colonic interposition postoesophagectomy","volume":"55","author":"Coevoet","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"key":"2026020209423902800_ref17","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1007\/s11605-018-3735-8","article-title":"Colonic interposition after adult Oesophagectomy: systematic review and meta-analysis of conduit choice and outcome","volume":"22","author":"Brown","year":"2018","journal-title":"J Gastrointest Surg"},{"key":"2026020209423902800_ref18","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1001\/archsurg.138.3.303","article-title":"Colonic interposition after esophagectomy for cancer","volume":"138","author":"Davis","year":"2003","journal-title":"Arch Surg"},{"key":"2026020209423902800_ref19","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1097\/SLA.0000000000001445","article-title":"Prospective study of malabsorption and malnutrition after Esophageal and gastric cancer surgery","volume":"262","author":"Heneghan","year":"2015","journal-title":"Ann Surg"},{"key":"2026020209423902800_ref20","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1097\/SLA.0b013e3181deb4b7","article-title":"Risk factors for development of benign cervical strictures after esophagectomy","volume":"251","author":"van Heijl","year":"2010","journal-title":"Ann Surg"},{"key":"2026020209423902800_ref21","first-page":"32","volume-title":"Functionele klachten na een slokdarm- of maagkankeroperatie, een multidisciplinaire aanpak","author":"'t Hoen","year":"2021"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/39\/1\/doaf126\/66707915\/doaf126.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/39\/1\/doaf126\/66707915\/doaf126.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:42:41Z","timestamp":1770043361000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article\/doi\/10.1093\/dote\/doaf126\/8454862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,9]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,9]]}},"URL":"https:\/\/doi.org\/10.1093\/dote\/doaf126","relation":{},"ISSN":["1120-8694","1442-2050"],"issn-type":[{"value":"1120-8694","type":"print"},{"value":"1442-2050","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2026,1,9]]},"article-number":"doaf126"}}