{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T18:02:26Z","timestamp":1771351346830,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Thoracic duct obliteration (TDO), either ligation or resection, is performed during esophagectomy to enhance oncological radicality or manage chylothorax. However, its nutritional and oncological effects are unclear. We retrospectively analyzed patients undergoing esophagectomy for esophageal cancer at our institution between January 2016 and May 2024. We assessed laboratory parameters and computed tomography-derived body composition indices from diagnosis to 9\u201312\u00a0months postoperatively (15\u201325\u00a0months for laboratory data). We also analyzed nutritional indices, overall survival (OS), and recurrence-free survival (RFS). A total of 82 patients underwent TDO, and 313 did not (non-TDO). After propensity score matching, we included 75 TDO and 150 non-TDO patients. The TDO group achieved a higher lymph node yield, without affecting chylothorax incidence, nutritional or body composition indices, OS, RFS, or recurrence patterns between the TDO and non-TDO groups. However, analysis of neoadjuvant therapy (NAT) subgroup found more subcutaneous fat loss 3\u20136\u00a0months postoperatively in TDO patients (\u221255.35% vs. \u221232.93%, P\u2009=\u20090.002). This difference was no longer evident at 9\u201312\u00a0months (\u221242.97% vs. \u221242.89%, P\u2009=\u20090.859). Among the NAT patients, thoracic duct resection was associated with better OS and RFS than non-resection (3-year OS: 77.15% vs. 57.25%, P\u2009=\u20090.038; 3-year RFS: 72.41% vs. 48.08%, P\u2009=\u20090.049). In conclusion, TDO during esophagectomy does not compromise long-term nutritional or oncological outcomes in patients with esophageal cancer. In the NAT subgroup, transient subcutaneous fat loss was evident during the early postoperative period but was no longer apparent after a year. Survival outcomes were better among NAT patients who received thoracic duct resection.<\/jats:p>","DOI":"10.1093\/dote\/doag010","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T12:43:18Z","timestamp":1770208998000},"source":"Crossref","is-referenced-by-count":0,"title":["Nutritional and prognostic effects of thoracic duct obliteration during esophagectomy"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0284-3570","authenticated-orcid":false,"given":"Chia","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]},{"name":"School of Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]},{"name":"Institute of Biomedical Informatics, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Ying","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-I","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Nursing, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Xuan","family":"Tao","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-2869","authenticated-orcid":false,"given":"Chien-Sheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]},{"name":"School of Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Shui","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]},{"name":"School of Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Hu","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]},{"name":"School of Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1790-0227","authenticated-orcid":false,"given":"Po-Kuei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]},{"name":"School of Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"issue":"1","key":"2026021712035181900_ref1","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/jso.26827","article-title":"Prophylactic thoracic duct obliteration and resection during esophagectomy: what is the impact on perioperative risks and long-term survival? A systematic review and meta-analysis","volume":"126","author":"Dos Santos","year":"2022","journal-title":"J Surg Oncol"},{"issue":"6","key":"2026021712035181900_ref2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17060967","article-title":"Resection vs. ligation vs. preservation of the thoracic duct during esophagectomy for cancer: a systematic review and meta-analysis","volume":"17","author":"Nijssen","year":"2025","journal-title":"Cancers (Basel)"},{"issue":"10","key":"2026021712035181900_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doad015","article-title":"Oncological and physiological impact of thoracic duct resection in esophageal cancer","volume":"36","author":"Matsuda","year":"2023","journal-title":"Dis Esophagus"},{"key":"2026021712035181900_ref4","doi-asserted-by":"publisher","first-page":"111534","DOI":"10.1016\/j.nut.2021.111534","article-title":"Body composition in relation to postoperative anastomotic leakage and overall survival in patients with esophageal cancer","volume":"94","author":"Li","year":"2022","journal-title":"Nutrition."},{"key":"2026021712035181900_ref5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/dote\/dox110","article-title":"Nutritional optimization during neoadjuvant therapy prior to surgical resection of esophageal cancer-a narrative review","volume":"31","author":"Huddy","year":"2018","journal-title":"Dis Esophagus"},{"issue":"6","key":"2026021712035181900_ref6","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.gassur.2024.03.001","article-title":"Sarcopenia impacts perioperative and survival outcomes after esophagectomy for cancer: a multicenter study","volume":"28","author":"Park","year":"2024","journal-title":"J Gastrointest Surg"},{"issue":"9","key":"2026021712035181900_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doad002","article-title":"The impact of thoracic duct resection on the long-term body composition of patients who underwent esophagectomy for esophageal cancer and survived without recurrence","volume":"36","author":"Nishimura","year":"2023","journal-title":"Dis Esophagus"},{"issue":"13","key":"2026021712035181900_ref8","doi-asserted-by":"publisher","first-page":"8414","DOI":"10.1245\/s10434-021-10222-8","article-title":"Nutritional outcomes of thoracic duct resection for radical esophagectomy by assessing body composition changes in one year: a single-center retrospective study","volume":"28","author":"Fujisawa","year":"2021","journal-title":"Ann Surg Oncol"},{"issue":"11","key":"2026021712035181900_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doae064","article-title":"Esophagectomy in patients with esophageal squamous cell carcinoma and distant nodal metastasis","volume":"37","author":"Liu","year":"2024","journal-title":"Dis Esophagus"},{"issue":"8","key":"2026021712035181900_ref10","doi-asserted-by":"publisher","first-page":"110062","DOI":"10.1016\/j.ejso.2025.110062","article-title":"Oncological outcomes of thoracic duct preservation and resection for esophageal carcinoma based on an understanding of its surgical microanatomy in the era of minimally invasive esophagectomy and neoadjuvant chemotherapy","volume":"51","author":"Igaue","year":"2025","journal-title":"Eur J Surg Oncol"},{"issue":"5","key":"2026021712035181900_ref11","doi-asserted-by":"publisher","first-page":"e1018","DOI":"10.1097\/SLA.0000000000005340","article-title":"Prognosis of patients with esophageal carcinoma after routine thoracic duct resection: a propensity-matched analysis of 12,237 patients based on the comprehensive registry of esophageal cancer in Japan","volume":"277","author":"Oshikiri","year":"2023","journal-title":"Ann Surg"},{"issue":"1","key":"2026021712035181900_ref12","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1245\/s10434-024-16303-8","article-title":"Prognostic impact of thoracic duct resection in patients who underwent transthoracic esophagectomy following neoadjuvant therapy for esophageal squamous cell carcinoma: exploratory analysis of JCOG1109","volume":"32","author":"Matsuda","year":"2025","journal-title":"Ann Surg Oncol"},{"issue":"9","key":"2026021712035181900_ref13","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1245\/s10434-018-6640-1","article-title":"Risk factors for postoperative chylothorax after radical subtotal esophagectomy","volume":"25","author":"Ohkura","year":"2018","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"2026021712035181900_ref14","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/s10388-014-0433-9","article-title":"Should lymph nodes along the thoracic duct be dissected routinely in radical esophagectomy?","volume":"nnn11","author":"Udagawa","year":"2014","journal-title":"Esophagus"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/39\/1\/doag010\/66963180\/doag010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/39\/1\/doag010\/66963180\/doag010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T17:03:57Z","timestamp":1771347837000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article\/doi\/10.1093\/dote\/doag010\/8488874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,9]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,9]]}},"URL":"https:\/\/doi.org\/10.1093\/dote\/doag010","relation":{},"ISSN":["1120-8694","1442-2050"],"issn-type":[{"value":"1120-8694","type":"print"},{"value":"1442-2050","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2026,1,9]]},"article-number":"doag010"}}