{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T10:07:56Z","timestamp":1772446076024,"version":"3.50.1"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Paraconduit hiatal hernia (PCH) is a serious complication following esophagectomy with significant morbidity and mortality. We aimed to conduct a comprehensive review to describe the prognostic factors for PCH in adult patients following esophagectomy for esophageal or gastric cancer to better understand which patients at risk. A systematic search was carried out in Ovid MEDLINE, Embase and Web-of-Science, from inception to August-2024. All studies of adult patients assessing risk factors for radiologically-confirmed PCH following esophagectomy for upper gastrointestinal cancers were included. The data showed that a minimally-invasive esophagectomy was associated with a significant increase in risk of developing PCH (odds ratio [OR]: 4.29, 95% confidence interval [CI]: 1.09\u201316.87; P\u2009=\u20090.04), particularly following laparoscopic-abdominal approach (hazard ratio [HR]: 2.98, 95% CI: 1.60\u20135.55; P\u2009&amp;lt;\u20090.01), and a 203% increase following extensive lymphadenectomy (OR: 3.03, 95% CI: 1.14\u20138.05; P\u2009=\u20090.03). A prophylactic-cruroplasty was not found to be associated with this complication (P\u2009=\u20090.18). Neoadjuvant-chemotherapy and neoadjuvant-chemoradiotherapy (nCRT) were both found to be associated with an increased risk of PCH (HR: 1.56, 95% CI: 0.58\u20134.17, P\u2009&amp;lt;\u20090.01; HR: 4.27 95% CI: 1.70\u201310.76; P\u2009&amp;lt;\u20090.01). Tumors located at gastro-esophageal-junction (GOJ) were associated with the greatest risk (HR: 3.51, 95% CI: 1.91\u20136.45; P\u2009&amp;lt;\u20090.01). In terms of clinical risk factors, patients with body-mass index (BMI) &amp;lt;25 (OR: 2.00, 95% CI: 1.10\u20133.70; P\u2009=\u20090.03), a pre-operative hiatus hernia (HH) (HR: 1.72, 95% CI: 1.01\u20132.94; P\u2009&amp;lt;\u20090.05) and those who had previous hiatal-surgery (HR:3.68, 95% CI: 1.61\u20138.45; P\u2009&amp;lt;\u20090.01) were associated with increased risk of developing PCH. The current literature suggests an associative trend between patients with BMI less than 25; nCRT; laparoscopic resection; GOJ tumor location; previous HH or hiatal surgery, and developing a PCH post-operatively.<\/jats:p>","DOI":"10.1093\/dote\/doag017","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:47:29Z","timestamp":1770814049000},"source":"Crossref","is-referenced-by-count":0,"title":["Prognostic factors for paraconduit hernia in adult patients post-esophagectomy for cancer: a systematic review"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7109-687X","authenticated-orcid":false,"given":"Abdel-Rahman","family":"Abdel Fattah","sequence":"first","affiliation":[{"name":"School of Medicine, Medical Sciences and Nutrition, University of Aberdeen , Aberdeen 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