{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:36:11Z","timestamp":1774974971861,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disease with increasing prevalence. Squamous papilloma of the esophagus is a rare benign lesion, with prevalence estimates of 0.014%\u20130.45% and association in EoE has not been reported. Our aims were to determine the prevalence of papilloma in a large cohort of EoE adults and clinical features of EoE associated with papilloma.<\/jats:p>\n                  <jats:p>We performed a retrospective chart review of EoE adults at two academic centers from 2002 to 2013 using current EoE consensus guidelines. Extracted data included patient demographics, clinical features, endoscopic findings, and histological information. Papilloma findings were confirmed by review by a senior gastrointestinal pathologist. A subset of papilloma biopsies was stained for human papilloma virus (HPV) and cell proliferation via ki-67 staining.<\/jats:p>\n                  <jats:p>In a cohort of 454 EoE patients, 41 patients (9%) presented with a papilloma. 46% were male, median age of 42\u00a0years (ranging 18\u201382). The median size of papilloma was 3\u00a0mm (range 1\u20135\u00a0mm); 63% were in the mid\/proximal esophagus. Features of age, disease duration, eosinophil count, and atopy did not differentiate EoE patients with\/without papilloma. Patients with papilloma were more likely to be female, have endoscopic exudates and edema. Papillomas stained negative for HPV and normal ki-67 staining.<\/jats:p>\n                  <jats:p>(1) The prevalence of papilloma in EoE adults was 9%, which represents a 24-fold increase than estimates in the general population. (2) Female gender and inflammatory endoscopic features were more common in EoE patients with papillomas. (3) The clinical significance of papilloma in EoE is unknown and merits further investigation.<\/jats:p>","DOI":"10.1093\/dote\/doag022","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:54:35Z","timestamp":1774968875000},"source":"Crossref","is-referenced-by-count":0,"title":["Increased prevalence of esophageal squamous cell papilloma in eosinophilic esophagitis: incidental finding or disease related consequence?"],"prefix":"10.1093","volume":"39","author":[{"given":"Angelika","family":"Zalewski","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine , Chicago , IL,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Stanford University School of Medicine , Palo Alto, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy A","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Pathology, Stanford University School of Medicine , Palo Alto, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Surgical Pathology, Department of Pathology, Northwestern University Feinberg School of Medicine , Chicago, IL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guinwa","family":"Khaddaj","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Mayo College of Medicine , Jacksonville, FL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna","family":"Murli","sequence":"additional","affiliation":[{"name":"Division of Pathology, Mayo College of Medicine , Jacksonville, FL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami R","family":"Achem","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Mayo College of Medicine , Jacksonville, FL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"Hirano","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine , Chicago , IL,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirmala","family":"Gonsalves","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Northwestern University Feinberg School of Medicine , Chicago , IL,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"issue":"8","key":"2026033110542811700_ref1","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1097\/00000478-199308000-00005","article-title":"Esophageal squamous papillomas: a clinicopathologic study of 38 lesions and analysis for human papilloma virus by the polymerase chain reaction","volume":"17","author":"Odze","year":"1993","journal-title":"Am J Surg Pathol"},{"key":"2026033110542811700_ref2","first-page":"194","article-title":"Squamous papilloma of the esophagus: a case report and review of the literature","volume":"83","author":"Quitadamo","year":"1988","journal-title":"Am J Gastroenterol"},{"key":"2026033110542811700_ref3","first-page":"625","article-title":"Papilloma of the esophagus: association with hiatal hernia","volume":"37","author":"Adler","year":"1958","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026033110542811700_ref4","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0022-5223(19)42966-8","article-title":"Benign and malignant tumors of the esophagus at autopsy","volume":"55","author":"Attah","year":"1968","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026033110542811700_ref5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3109\/00365529108998577","article-title":"Esophageal squamous cell papillomas: failure to detect human papillomavirus DNA by in situ hybridization and polymerase chain reaction","volume":"26","author":"Chang","year":"1991","journal-title":"Scand J Gastroenterol"},{"key":"2026033110542811700_ref6","first-page":"1059","article-title":"Squamous papilloma of the esophagus: report of six cases with long term follow-up in four patients","volume":"81","author":"Fernandez-Rodriquez","year":"1986","journal-title":"Am J Gastroenterol"},{"key":"2026033110542811700_ref7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-2007-1018114","article-title":"Squamous cell papilloma of the esophagus: report of 35 endoscopic cases","volume":"20","author":"Sablich","year":"1988","journal-title":"Endoscopy"},{"key":"2026033110542811700_ref8","first-page":"240","article-title":"Squamous papilloma of the esophagus (letter)","volume":"31","author":"Franzin","year":"1985","journal-title":"Gastrointest Endosc"},{"key":"2026033110542811700_ref9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1267\/ahc.39.23","article-title":"Clinicopathological characteristics of esophageal squamous papillomas in Japanese patients\u2014with comparison of findings from western countries","volume":"39","author":"Takeshita","year":"2006","journal-title":"Acta Histochem Cytochem"},{"key":"2026033110542811700_ref10","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1046\/j.1440-1746.2001.02531.x","article-title":"Squamous papilloma of the esophagus: long-term follow up","volume":"16","author":"Mosca","year":"2001","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"2026033110542811700_ref11","doi-asserted-by":"publisher","first-page":"E101","DOI":"10.1055\/s-0034-1390976","article-title":"Prevalence of esophageal squamous papilloma (ESP) and associated cancer in northeastern France","volume":"3","author":"d'Huart","year":"2015","journal-title":"Endosc Int Open"},{"key":"2026033110542811700_ref12","first-page":"245","article-title":"Squamous cell papillomas of the esophagus: a clinicopatholocic and follow-up study of 25 cases","volume":"89","author":"Carr","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"2026033110542811700_ref13","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/0016-5085(78)90153-1","article-title":"Squamous cell papilloma of the esophagus: report of a case after peptic esophagitis and repeated bougienage with review of the literature","volume":"74","author":"Parnell","year":"1978","journal-title":"Gastroenterology"},{"key":"2026033110542811700_ref14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1023\/A:1026695600375","article-title":"Squamous cell papillomatosis of esophagus following placement of a self-expanding metal stent","volume":"44","author":"Karras","year":"1999","journal-title":"Dig Dis Sci"},{"key":"2026033110542811700_ref15","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/0016-5085(95)90085-3","article-title":"Human papillomavirus type 16-positive esophageal papilloma an endoscopic injection sclerotherapy site","volume":"108","author":"Yamada","year":"1995","journal-title":"Gastroenterology"},{"key":"2026033110542811700_ref16","first-page":"1471","article-title":"Pathology of esophageal neoplasms and associated proliferative lesions induced in rats by N-methyl-N-benzylnitrosamine","volume":"61","author":"Stinson","year":"1978","journal-title":"J Natl Cancer Inst"},{"key":"2026033110542811700_ref17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/jnci\/58.2.313","article-title":"Histopathology of preneoplastic and neoplastic lesions of the esophagus in BUF rats ingesting diethylnitrosamine","volume":"58","author":"Reuber","year":"1977","journal-title":"J Natl Cancer Inst"},{"key":"2026033110542811700_ref18","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/0046-8177(94)90128-7","article-title":"Squamous cell papilloma of the esophagus: a study of 23 lesions for human papillomavirus by in situ hybridization and the polymerase chain reaction","volume":"25","author":"Carr","year":"1994","journal-title":"Hum Pathol"},{"key":"2026033110542811700_ref19","first-page":"965","article-title":"Human papillomavirus infection in esophageal squamous cell papilloma: a study of 29 lesions","volume":"15","author":"Poljak","year":"1995","journal-title":"Anticancer Res"},{"key":"2026033110542811700_ref20","first-page":"363","article-title":"Detection of human papillomavirus in esophageal papillomas: systemic review and meta-analysis","volume":"121","author":"Syrjanen","year":"2013","journal-title":"APIMS"},{"key":"2026033110542811700_ref21","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1053\/j.gastro.2007.08.017","article-title":"Eosinopihilic esophagitis in children and adults: a systemic review and consensus recommendations for diagnosis and treatment","volume":"133","author":"Furuta","year":"2007","journal-title":"Gastroenterology"},{"key":"2026033110542811700_ref22","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jaci.2011.02.040","article-title":"Eosinophilic esophagitis: updated consensus recommendations for children and adults","volume":"128","author":"Liacouras","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"2026033110542811700_ref23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.gie.2006.04.037","article-title":"Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis","volume":"64","author":"Gonsalves","year":"2006","journal-title":"Gastrointest Endosc"},{"key":"2026033110542811700_ref24","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1053\/j.gastro.2013.08.015","article-title":"Delay in diagnosis of eosinophilic esophagitis increases risk for stricture formation in a time-dependent manner","volume":"145","author":"Schoepfer","year":"2013","journal-title":"Gastroenterology"},{"key":"2026033110542811700_ref25","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/ajg.2012.469","article-title":"Assessment and protection of esophageal mucosal integrity in patients with heartburn without esophagitis","volume":"108","author":"Woodland","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"2026033110542811700_ref26","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/mi.2013.90","article-title":"Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis","volume":"7","author":"Sherrill","year":"2013","journal-title":"Mucosal Immunol"},{"key":"2026033110542811700_ref27","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/j.1398-9995.2012.02787.x","article-title":"Pediatric and adult eosinophilic esophagitis: similarities and differences","volume":"67","author":"Straumann","year":"2012","journal-title":"Allergy"},{"key":"2026033110542811700_ref28","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/ajg.2008.40","article-title":"Pathology of eosinophilic esophagitis: what the clinician needs to know","volume":"104","author":"Odze","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"2026033110542811700_ref29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1042\/CS20050369","article-title":"Molecular biology of human papillomavirus infection and cervical cancer","volume":"110","author":"Doorbar","year":"2006","journal-title":"Clin Sci"},{"key":"2026033110542811700_ref30","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1111\/j.1572-0241.2000.02106.x","article-title":"Esophageal squamous cell papillomatosis complicated by carcinoma","volume":"95","author":"Waluga","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"2026033110542811700_ref31","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1442-2050.2004.00438.x","article-title":"Esophageal papillomatosis complicated by squamous cell carcinoma in situ","volume":"17","author":"Reynoso","year":"2004","journal-title":"Dis Esophagus"},{"key":"2026033110542811700_ref32","first-page":"487","article-title":"Squamous papilloma of the esophagus diagnosed by cytology: report of a case with concurrent occult epidermoid carcinoma","volume":"30","author":"Borges","year":"1986","journal-title":"Acta Cytol"},{"key":"2026033110542811700_ref33","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1136\/jcp.55.10.721","article-title":"HPV infections and oesophageal cancer","volume":"55","author":"Syrjanen","year":"2002","journal-title":"J Clin Pathol"},{"key":"2026033110542811700_ref34","first-page":"413","article-title":"Squamous papilloma of the esophagus","volume":"57","author":"Lio","year":"1996","journal-title":"Zhonghua Yi Zue Za Zhi"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/39\/2\/doag022\/67694833\/doag022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/39\/2\/doag022\/67694833\/doag022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:54:38Z","timestamp":1774968878000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article\/doi\/10.1093\/dote\/doag022\/8566342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3,2]]}},"URL":"https:\/\/doi.org\/10.1093\/dote\/doag022","relation":{},"ISSN":["1120-8694","1442-2050"],"issn-type":[{"value":"1120-8694","type":"print"},{"value":"1442-2050","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,3,2]]},"article-number":"doag022"}}