{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:28:23Z","timestamp":1776410903731,"version":"3.51.2"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Endoscopic submucosal dissection (ESD) is the preferred treatment for early esophageal neoplasms. However, ESD involving more than three-quarters of the esophageal circumference often leads to stricture formation. While corticosteroids are widely used to prevent strictures, the optimal route of administration remains unclear. This study aimed to compare submucosal corticosteroid injection (IC) with oral corticosteroid administration (OC) in decreasing the number of dilations required for stricture resolution, stricture rate, and stricture resolution rate. This was a single-center, open-label, randomized clinical trial. Thirty patients with esophageal mucosal defects involving more than three-quarters of the esophageal circumference were enrolled and randomly assigned to two groups. The IC group received 100\u00a0mg of triamcinolone injected into the resection bed immediately after the procedure. The OC group was given oral prednisolone starting 3\u00a0days post-ESD, initially at 30\u00a0mg\/day, tapered over 8\u00a0weeks. A total of 30 patients were included, 15 in each group. The OC group required significantly fewer dilation sessions than the IC group (5 vs. 19; P\u00a0=\u20090.04). However, the stricture rate was similar between the groups (OC: 66.7% vs. IC: 40%; P\u00a0=\u20090.27), as well as the stricture resolution rate (OC: 50% vs. IC: 40%; P\u00a0&amp;gt;\u20090.99). No significant differences were observed in other adverse events or blood glucose levels between the groups. Oral corticosteroids resulted in fewer dilation sessions to resolve strictures after extensive esophageal ESD compared to intralesional injections. No differences were observed in stricture rates or other adverse events between the two groups. ClinicalTrials.gov (NCT04498260).<\/jats:p>","DOI":"10.1093\/dote\/doag027","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:48:37Z","timestamp":1773330517000},"source":"Crossref","is-referenced-by-count":0,"title":["Randomized trial of intralesional steroid injection versus oral prednisolone for preventing esophageal stricture after extensive endoscopic submucosal dissection"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1082-1254","authenticated-orcid":false,"given":"Joel Fernandez","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Endoscopia Gastrointestinal, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo (ICESP) da Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP) , S\u00e3o Paulo, SP ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0282-0753","authenticated-orcid":false,"given":"Bruno Costa","family":"Martins","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endoscopia Gastrointestinal, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo (ICESP) da Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP) , S\u00e3o Paulo, SP ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0629-8050","authenticated-orcid":false,"given":"Renata Nobre","family":"Moura","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endoscopia Gastrointestinal, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo (ICESP) da Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP) , S\u00e3o Paulo, SP ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Andrade","family":"de Paulo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endoscopia Gastrointestinal, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo (ICESP) da Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP) , S\u00e3o Paulo, SP ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Lenz","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endoscopia Gastrointestinal, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo (ICESP) da Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP) , S\u00e3o Paulo, SP ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Simas","family":"de Lima","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endoscopia Gastrointestinal, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo (ICESP) da Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP) , S\u00e3o Paulo, SP ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Vaz","family":"Safatle-Ribeiro","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endoscopia Gastrointestinal, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo (ICESP) da Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP) , S\u00e3o Paulo, SP ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fauze","family":"Maluf-Filho","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endoscopia Gastrointestinal, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo (ICESP) da Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP) , S\u00e3o Paulo, SP ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"2026041702363850100_ref1","volume-title":"Lyon, France: International Agency for Research on Cancer","author":"Ferlay","year":"2022"},{"key":"2026041702363850100_ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10388-014-0465-1","article-title":"Guidelines for diagnosis and treatment of carcinoma of the Esophagus April 2012 edited by the Japan Esophageal society","volume":"12","author":"Kuwano","year":"2015","journal-title":"Esophagus"},{"issue":"6","key":"2026041702363850100_ref3","doi-asserted-by":"publisher","first-page":"E753","DOI":"10.1055\/a-1789-0266","article-title":"Clinical effectiveness of short course oral prednisone for stricture prevention after semi-circumferential esophageal endoscopic submucosal dissection","volume":"10","author":"Arantes","year":"2022","journal-title":"Endosc Int Open"},{"issue":"Suppl 1","key":"2026041702363850100_ref4","first-page":"S4","article-title":"Endoscopic submucosal dissection in the upper gastrointestinal tract: present and future view of Europe","volume":"21","author":"Neuhaus","year":"2009","journal-title":"Dig Endosc"},{"issue":"2","key":"2026041702363850100_ref5","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1067\/mge.2003.73","article-title":"Esophageal stenosis after endoscopic mucosal resection of superficial esophageal lesions","volume":"57","author":"Katada","year":"2003","journal-title":"Gastrointest Endosc"},{"issue":"5","key":"2026041702363850100_ref6","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.gie.2009.04.044","article-title":"Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms","volume":"70","author":"Ono","year":"2009","journal-title":"Gastrointest Endosc"},{"issue":"1","key":"2026041702363850100_ref7","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3892\/etm.2012.753","article-title":"Clinical value of preventive balloon dilatation for esophageal stricture","volume":"5","author":"Wang","year":"2013","journal-title":"Exp Ther Med"},{"issue":"3","key":"2026041702363850100_ref8","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s10388-023-00993-2","article-title":"Esophageal cancer practice guidelines 2022 edited by the Japan esophageal society: part 1","volume":"20","author":"Kitagawa","year":"2023","journal-title":"Esophagus"},{"issue":"7","key":"2026041702363850100_ref9","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1007\/s00464-015-4551-9","article-title":"Prevention of esophageal stricture after endoscopic submucosal dissection: a systematic review and meta-analysis","volume":"30","author":"Oliveira","year":"2016","journal-title":"Surg Endosc Other Interv Tech"},{"issue":"2","key":"2026041702363850100_ref10","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.gie.2013.01.008","article-title":"Control of severe strictures after circumferential endoscopic submucosal dissection for esophageal carcinoma: oral steroid therapy with balloon dilation or balloon dilation alone","volume":"78","author":"Sato","year":"2013","journal-title":"Gastrointest Endosc"},{"key":"2026041702363850100_ref11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12876-014-0226-6","article-title":"A randomized controlled trial of endoscopic steroid injection for prophylaxis of esophageal stenoses after extensive endoscopic submucosal dissection","volume":"15","author":"Takahashi","year":"2015","journal-title":"BMC Gastroenterol"},{"key":"2026041702363850100_ref12","doi-asserted-by":"publisher","first-page":"e081123","DOI":"10.1136\/bmj-2024-081123","article-title":"CONSORT 2025 statement: updated guideline for reporting randomised trials","volume":"389","author":"Hopewell","year":"2025","journal-title":"BMJ"},{"issue":"Suppl 1","key":"2026041702363850100_ref13","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/den.13388","article-title":"Management of adverse events related to endoscopic resection of upper gastrointestinal neoplasms: review of the literature and recommendations from experts","volume":"31","author":"Yamamoto","year":"2019","journal-title":"Dig Endosc"},{"key":"2026041702363850100_ref14","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1016\/j.gie.2024.08.017","article-title":"Efficacy of different steroid therapy in preventing Esophageal stricture after endoscopic submucosal dissection: a comparative meta-analysis","volume":"100","author":"Zhou","year":"2024","journal-title":"Gastrointest Endosc"},{"issue":"1","key":"2026041702363850100_ref15","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1007\/s00464-021-08296-2","article-title":"Efficacy of oral steroid gel in preventing esophageal stricture after extensive endoscopic submucosal dissection: a randomized controlled trial","volume":"36","author":"Zhang","year":"2022","journal-title":"Surg Endosc"},{"issue":"3","key":"2026041702363850100_ref16","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/den.13496","article-title":"Prospective multicenter study of the esophageal triamcinolone acetonide-filling method in patients with subcircumferential esophageal endoscopic submucosal dissection","volume":"32","author":"Shibagaki","year":"2020","journal-title":"Dig Endosc"},{"issue":"11","key":"2026041702363850100_ref17","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1055\/s-0032-1310107","article-title":"Intralesional steroid injection to prevent stricture after endoscopic submucosal dissection for esophageal cancer: a controlled prospective study","volume":"44","author":"Hanaoka","year":"2012","journal-title":"Endoscopy"},{"issue":"7","key":"2026041702363850100_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/dox140","article-title":"Effectiveness of modified oral steroid administration for preventing esophageal stricture after entire circumferential endoscopic submucosal dissection","volume":"31","author":"Iizuka","year":"2018","journal-title":"Dis Esophagus"},{"issue":"11","key":"2026041702363850100_ref19","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1111\/1751-2980.12819","article-title":"Preventing esophageal strictures with steroids after endoscopic submucosal dissection in superficial esophageal neoplasm","volume":"20","author":"Pih","year":"2019","journal-title":"J Dig Dis"},{"issue":"11","key":"2026041702363850100_ref20","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1093\/jjco\/hyv120","article-title":"A phase III study of oral steroid administration versus local steroid injection therapy for the prevention of esophageal stricture after endoscopic submucosal dissection (JCOG1217, steroid EESD P3)","volume":"45","author":"Mizutani","year":"2015","journal-title":"Jpn J Clin Oncol"},{"issue":"3","key":"2026041702363850100_ref21","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1007\/s00464-012-2555-2","article-title":"1,635 endoscopic submucosal dissection cases in the esophagus, stomach, and colorectum: complication rates and long-term outcomes","volume":"27","author":"Toyonaga","year":"2013","journal-title":"Surg Endosc"},{"issue":"6 Suppl","key":"2026041702363850100_ref22","first-page":"S3","article-title":"The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon: November 30 to December 1, 2002","volume":"58","year":"2003","journal-title":"Gastrointest Endosc"},{"key":"2026041702363850100_ref23","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1471-230X-11-46","article-title":"Management of esophageal stricture after complete circular endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma","volume":"11","author":"Isomoto","year":"2011","journal-title":"BMC Gastroenterol"},{"issue":"8","key":"2026041702363850100_ref24","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1055\/s-0029-1214867","article-title":"Predictors of postoperative stricture after esophageal endoscopic submucosal dissection for superficial squamous cell neoplasms","volume":"41","author":"Ono","year":"2009","journal-title":"Endoscopy"},{"issue":"6","key":"2026041702363850100_ref25","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/j.gie.2011.07.070","article-title":"The efficacy of endoscopic triamcinolone injection for the prevention of esophageal stricture after endoscopic submucosal dissection","volume":"74","author":"Hashimoto","year":"2011","journal-title":"Gastrointest Endosc"},{"issue":"3","key":"2026041702363850100_ref26","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1007\/s10620-013-2958-5","article-title":"Preventing stricture formation by covered esophageal stent placement after endoscopic submucosal dissection for early esophageal cancer","volume":"59","author":"Wen","year":"2014","journal-title":"Dig Dis Sci"},{"key":"2026041702363850100_ref27","doi-asserted-by":"publisher","author":"Uno","DOI":"10.3748\/wjg.v21.i23.7120"},{"issue":"3","key":"2026041702363850100_ref28","doi-asserted-by":"publisher","first-page":"241","DOI":"10.5946\/ce.2015.099","article-title":"Esophageal stricture prevention after endoscopic submucosal dissection","volume":"49","author":"Jain","year":"2016","journal-title":"Clin Endosc"},{"key":"2026041702363850100_ref29","first-page":"5380815","article-title":"Roles of steroids in preventing esophageal stricture after endoscopic resection","author":"Qiu","year":"2019","journal-title":"Can J Gastroenterol Hepatol"},{"issue":"5","key":"2026041702363850100_ref30","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1055\/s-0042-123189","article-title":"Prevention of esophageal stricture after endoscopic submucosal dissection using RNA-based silencing of carbohydrate sulfotransferase 15 in a porcine model","volume":"49","author":"Sato","year":"2017","journal-title":"Endoscopy"},{"issue":"20","key":"2026041702363850100_ref31","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.3760\/cma.j.cn112137-20210905-02024","article-title":"Effect and mechanism of glucocorticoids in preventing stenosis after esophageal endoscopic submucosal dissection","volume":"102","author":"Wu","year":"2022","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"6","key":"2026041702363850100_ref32","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1111\/jgh.14580","article-title":"Efficacy and safety of steroid in the prevention of esophageal stricture after endoscopic submucosal dissection: a network meta-analysis","volume":"34","author":"Yang","year":"2019","journal-title":"J Gastroenterol Hepatol"},{"key":"2026041702363850100_ref33","volume-title":"World J Surg.","author":"Yu"},{"issue":"4","key":"2026041702363850100_ref34","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1007\/s00464-018-6404-9","article-title":"Long-term efficacy and safety of intralesional steroid injection plus oral steroid administration in preventing stricture after endoscopic submucosal dissection for esophageal epithelial neoplasms","volume":"33","author":"Chu","year":"2019","journal-title":"Surg Endosc"},{"issue":"2","key":"2026041702363850100_ref35","doi-asserted-by":"publisher","first-page":"e75","DOI":"10.1038\/ctg.2017.5","article-title":"Single locoregional triamcinolone injection immediately after esophageal endoscopic submucosal dissection prevents stricture formation","volume":"8","author":"Nagami","year":"2017","journal-title":"Clin Transl Gastroenterol"},{"issue":"7","key":"2026041702363850100_ref36","doi-asserted-by":"publisher","first-page":"E573","DOI":"10.1055\/s-0043-110077","article-title":"Risk of perforation in balloon dilation associated with steroid injection for preventing esophageal stricture after endoscopic submucosal dissection","volume":"5","author":"Tsujii","year":"2017","journal-title":"Endosc Int Open"},{"issue":"12","key":"2026041702363850100_ref37","doi-asserted-by":"publisher","first-page":"E1267","DOI":"10.1055\/s-0042-118291","article-title":"Prophylactic steroid administration for strictures after endoscopic resection of large superficial esophageal squamous cell carcinoma","volume":"4","author":"Kadota","year":"2016","journal-title":"Endosc Int Open"},{"issue":"5","key":"2026041702363850100_ref38","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/1759-7714.12473","article-title":"Efficacy of prednisone for prevention of esophageal stricture after endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma","volume":"8","author":"Zhou","year":"2017","journal-title":"Thorac Cancer"},{"issue":"2","key":"2026041702363850100_ref39","doi-asserted-by":"publisher","first-page":"E113","DOI":"10.1055\/s-0034-1390797","article-title":"Efficacy of short period, low dose oral prednisolone for the prevention of stricture after circumferential endoscopic submucosal dissection (ESD) for esophageal cancer","volume":"3","author":"Kataoka","year":"2015","journal-title":"Endosc Int Open"},{"issue":"6","key":"2026041702363850100_ref40","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.gie.2011.02.005","article-title":"Usefulness of oral prednisolone in the treatment of esophageal stricture after endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma","volume":"73","author":"Yamaguchi","year":"2011","journal-title":"Gastrointest Endosc"},{"issue":"9","key":"2026041702363850100_ref41","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.3748\/wjg.v24.i9.1046","article-title":"Effect of polyglycolic acid sheet plus esophageal stent placement in preventing esophageal stricture after endoscopic submucosal dissection in patients with early-stage esophageal cancer: a randomized, controlled trial","volume":"24","author":"Chai","year":"2018","journal-title":"World J Gastroenterol"},{"issue":"11","key":"2026041702363850100_ref42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/dote\/dox053","article-title":"Polyglycolic acid sheet and fibrin glue for preventing esophageal stricture after endoscopic submucosal dissection: a historical control study","volume":"30","author":"Iizuka","year":"2017","journal-title":"Dis Esophagus"},{"issue":"6","key":"2026041702363850100_ref43","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.gie.2020.04.070","article-title":"Steroid injection and polyglycolic acid shielding to prevent stricture after esophageal endoscopic submucosal dissection: a retrospective comparative analysis (with video)","volume":"92","author":"Sakaguchi","year":"2020","journal-title":"Gastrointest Endosc"},{"issue":"10","key":"2026041702363850100_ref44","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1055\/a-1774-4630","article-title":"Tube-in-tube endoscopic vacuum therapy for the closure of upper gastrointestinal fistulas, leaks, and perforations","volume":"54","author":"Simas de Lima","year":"2022","journal-title":"Endoscopy"},{"issue":"Suppl 2 UCTN","key":"2026041702363850100_ref45","doi-asserted-by":"publisher","first-page":"E92","DOI":"10.1055\/s-0032-1326253","article-title":"Delayed perforation after intralesional triamcinolone injection for esophageal stricture following endoscopic submucosal dissection","volume":"45","author":"Yamashina","year":"2013","journal-title":"Endoscopy"},{"issue":"3","key":"2026041702363850100_ref46","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1007\/s00464-015-4301-z","article-title":"Complete circular endoscopic resection using submucosal tunnel technique combined with esophageal stent placement for circumferential superficial esophageal lesions","volume":"30","author":"Ye","year":"2016","journal-title":"Surg Endosc"},{"issue":"1","key":"2026041702363850100_ref47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4253\/wjge.v16.i1.1","article-title":"Prospects of polyglycolic acid sheets for the treatment of esophageal stricture after esophageal endoscopic submucosal dissection. World","volume":"16","author":"Wang","year":"2024","journal-title":"J Gastrointest Endosc"},{"issue":"3","key":"2026041702363850100_ref48","doi-asserted-by":"publisher","first-page":"E354","DOI":"10.1055\/s-0042-100903","article-title":"Refractory strictures despite steroid injection after esophageal endoscopic resection","volume":"4","author":"Hanaoka","year":"2016","journal-title":"Endosc Int Open"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/39\/2\/doag027\/67725756\/doag027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/39\/2\/doag027\/67725756\/doag027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:36:47Z","timestamp":1776407807000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article\/doi\/10.1093\/dote\/doag027\/8572550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3,2]]}},"URL":"https:\/\/doi.org\/10.1093\/dote\/doag027","relation":{},"ISSN":["1442-2050"],"issn-type":[{"value":"1442-2050","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,3,2]]},"article-number":"doag027"}}