{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T17:45:20Z","timestamp":1776015920286,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>In the absence of a mechanical stricture, oropharyngeal dysphagia following esophageal cancer surgery, and swallowing physiology more broadly, is poorly understood. This study investigated oropharyngeal dysphagia within the first year following curative open esophageal resection. A prospective cohort study was conducted (January 2022 to January 2024) at the National Esophageal Cancer Centre in Ireland. Participants were recruited between 6 to 12\u00a0months post-esophagectomy. A standardized videofluoroscopy was completed. Outcome measures included the Dynamic Imaging Grade of Swallowing Toxicity (DIGESTv2), Modified Barium Swallow Impairment Profile (MBSImP), and Penetration-Aspiration Scale (PAS). Functional Oral Intake Scale (FOIS) was used to identify oral intake status. To evaluate the trajectory of oropharyngeal dysphagia, long-term data were compared to previously published acute data findings. Seventeen participants (12 males; mean age 65\u00a0years, range 46\u201380) were included. The cohort comprised transthoracic (2-stage n\u2009=\u20097, 3-stage n\u2009=\u20093) and transhiatal (n\u2009=\u20097) resections. 11 participants (65%) had persistent oropharyngeal dysphagia (DIGESTv2), and 2 (12%) continued to aspirate greater than 6-months, both of whom had a transhiatal resection. 10 (59%) continued to modify their diet (abnormal FOIS &amp;lt;7). MBSImP revealed impaired initiation of swallow (82%), anterior hyoid excursion (82%), tongue base retraction (100%), pharyngeal residue (100%) and neo-esophageal clearance (82%). When comparing acute to longer term data, there was a statistically significant difference in aspiration based on PAS (P =\u00a00.016), but not dysphagia based on the DIGESTv2 (P =\u00a00.500). Oropharyngeal dysphagia is prevalent within the first year following open esophageal cancer surgery. The study informs the need for structured guidelines and a swallowing care pathway.<\/jats:p>","DOI":"10.1093\/dote\/doag029","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:46:28Z","timestamp":1774010788000},"source":"Crossref","is-referenced-by-count":0,"title":["The prevalence, nature and trajectory of oropharyngeal dysphagia within the first year following curative open resection for esophageal cancer"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7996-8561","authenticated-orcid":false,"given":"Michelle","family":"Hayes","sequence":"first","affiliation":[{"name":"Department of Clinical Speech and Language Studies, Trinity College Dublin , Dublin 2 ,","place":["Ireland"]},{"name":"Department of Speech and Language Therapy, St. James\u2019 Hospital , Dublin 8 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9376-6130","authenticated-orcid":false,"given":"Anna","family":"Gillman","sequence":"additional","affiliation":[{"name":"Department of Clinical Speech and Language Studies, Trinity College Dublin , Dublin 2 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4673-0386","authenticated-orcid":false,"given":"Jessie A","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Surgery, St. James\u2019 Hospital , Dublin 8 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9373-2662","authenticated-orcid":false,"given":"Claire L","family":"Donohoe","sequence":"additional","affiliation":[{"name":"Department of Surgery, St. James\u2019 Hospital , Dublin 8 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5501-9521","authenticated-orcid":false,"given":"John V","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Surgery, St. James\u2019 Hospital , Dublin 8 ,","place":["Ireland"]},{"name":"Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin , Dublin 2 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5816-4516","authenticated-orcid":false,"given":"Julie","family":"Regan","sequence":"additional","affiliation":[{"name":"Department of Clinical Speech and Language Studies, Trinity College Dublin , Dublin 2 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"issue":"6","key":"2026041213035864400_ref1","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1007\/s12328-020-01237-x","article-title":"Epidemiology of esophageal cancer: update in global trends, etiology and risk factors","volume":"13","author":"Uhlenhopp","year":"2020","journal-title":"Clinical journal of gastroenterology"},{"issue":"3","key":"2026041213035864400_ref2","doi-asserted-by":"publisher","first-page":"161","DOI":"10.14423\/SMJ.0000000000001226","article-title":"Esophageal cancer: an updated review","volume":"114","author":"DiSiena","year":"2021","journal-title":"South Med J"},{"issue":"11","key":"2026041213035864400_ref3","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1111\/1759-7714.14835","article-title":"Epidemiological landscape of esophageal cancer in Asia: results from GLOBOCAN 2020","volume":"14","author":"Zhu","year":"2023","journal-title":"Thoracic Cancer"},{"issue":"10110","key":"2026041213035864400_ref4","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1016\/S0140-6736(17)31462-9","article-title":"Oesophageal cancer","volume":"390","author":"Lagergren","year":"2017","journal-title":"The Lancet"},{"issue":"3","key":"2026041213035864400_ref5","doi-asserted-by":"crossref","first-page":"zrab010","DOI":"10.1093\/bjsopen\/zrab010","article-title":"The esophagectomy complications consensus group (ECCG), and the Dutch upper gastrointestinal cancer audit (DUCA)","volume":"5","author":"Comparison of short-term outcomes from the international oesophago-gastric anastomosis audit (OGAA)","year":"2021","journal-title":"Bjs Open"},{"issue":"1","key":"2026041213035864400_ref6","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/bjs.11318","article-title":"Impact of postoperative complications on disease recurrence and long-term survival following oesophagogastric cancer resection. Journal of British","volume":"107","author":"JH","year":"2020","journal-title":"Surgery."},{"key":"2026041213035864400_ref7","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1186\/1472-6963-12-384","article-title":"Oesophagectomy rates and post-resection outcomes in patients with cancer of the oesophagus and gastro-oesophageal junction: a population-based study using linked health administrative linked data","volume":"12","author":"Stavrou","year":"2012","journal-title":"BMC Health Serv Res"},{"issue":"4","key":"2026041213035864400_ref8","doi-asserted-by":"publisher","first-page":"3316","DOI":"10.3390\/ijms24043316","article-title":"Biomarkers for early detection, prognosis, and therapeutics of esophageal cancers","volume":"24","author":"Rai","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"Suppl 5","key":"2026041213035864400_ref9","doi-asserted-by":"publisher","first-page":"S824","DOI":"10.21037\/jtd.2019.01.24","article-title":"Early oral feeding following esophagectomy","volume":"11","author":"Liu","year":"2019","journal-title":"J Thorac Dis"},{"issue":"6","key":"2026041213035864400_ref10","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1080\/0284186X.2020.1741677","article-title":"Patient-reported outcomes 1 year after oesophageal cancer surgery","volume":"59","author":"Schandl","year":"2020","journal-title":"Acta Oncol"},{"issue":"4","key":"2026041213035864400_ref11","doi-asserted-by":"publisher","DOI":"10.1080\/17549507.2024.2360065","article-title":"Long-term impact of aerodigestive symptoms on adults with oesophageal cancer: a qualitative study. International journal of speech-language","volume":"27","author":"Gillman","year":"2025","journal-title":"Pathology."},{"issue":"1","key":"2026041213035864400_ref12","doi-asserted-by":"publisher","first-page":"zraa038","DOI":"10.1093\/bjsopen\/zraa038","article-title":"Psychological distress and health-related quality of life up to 2 years after oesophageal cancer surgery: nationwide population-based study","volume":"5","author":"Liu","year":"2021","journal-title":"BJS open"},{"key":"2026041213035864400_ref13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ejca.2016.09.032","article-title":"Health-related quality of life 10 years after oesophageal cancer surgery","volume":"69","author":"Schandl","year":"2016","journal-title":"Eur J Cancer"},{"key":"2026041213035864400_ref14","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"Vandenbroucke, JP strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"335","author":"DG","year":"2007","journal-title":"BMJ."},{"issue":"22","key":"2026041213035864400_ref15","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1056\/NEJMoa1112088","article-title":"Preoperative chemoradiotherapy for esophageal or junctional cancer","volume":"366","author":"Hagen","year":"2012","journal-title":"New England Journal of Medicine"},{"issue":"10184","key":"2026041213035864400_ref16","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1016\/S0140-6736(18)32557-1","article-title":"Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2\/3 trial","volume":"393","author":"Al-Batran","year":"2019","journal-title":"The Lancet"},{"issue":"23","key":"2026041213035864400_ref17","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1056\/NEJMoa032709","article-title":"Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer","volume":"350","author":"Andr\u00e9","year":"2004","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"2026041213035864400_ref18","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1053\/j.optechstcvs.2009.06.001","article-title":"Technique of open Ivor Lewis esophagectomy","volume":"14","author":"Reed","year":"2009","journal-title":"Operative Techniques in Thoracic and Cardiovascular Surgery"},{"issue":"8","key":"2026041213035864400_ref19","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1442-2050.2009.00963.x","article-title":"Application of a modified McKeown procedure (thoracoscopic esophageal mobilization three-incision esophagectomy) in esophageal cancer surgery: initial experience with 30 cases","volume":"22","author":"Zhou","year":"2009","journal-title":"Dis Esophagus"},{"issue":"3","key":"2026041213035864400_ref20","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1097\/00000658-199909000-00012","article-title":"Transhiatal esophagectomy: clinical experience and refinements","volume":"230","author":"Orringer","year":"1999","journal-title":"Ann Surg"},{"issue":"8","key":"2026041213035864400_ref21","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1016\/j.apmr.2004.11.049","article-title":"Initial psychometric assessment of a functional oral intake scale for dysphagia in stroke patients","volume":"86","author":"Crary","year":"2005","journal-title":"Arch Phys Med Rehabil"},{"key":"2026041213035864400_ref22","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1007\/s00455-020-10130-1","article-title":"The landscape of Videofluoroscopy in the UK: a web-based survery","volume":"36","author":"Benfield","year":"2021","journal-title":"Dysphagia"},{"issue":"1","key":"2026041213035864400_ref23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s00455018-9915-6","article-title":"Characterizing the flow of thickened barium and non-barium liquid recipes using the IDDSI flow test","volume":"34","author":"Barbon","year":"2019","journal-title":"Dysphagia."},{"issue":"7","key":"2026041213035864400_ref24","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1136\/inpract.27.7.348","article-title":"Practical contrast radiography: 1","volume":"27","author":"Latham","year":"2005","journal-title":"Contrast agents In Practice"},{"key":"2026041213035864400_ref25","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/BF00417897","article-title":"A penetration-aspiration scale","volume":"11","author":"Rosenbek","year":"1996","journal-title":"Dysphagia."},{"issue":"7","key":"2026041213035864400_ref26","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1002\/cncr.34079","article-title":"Refining measurement of swallowing safety in the dynamic imaging grade of swallowing toxicity (DIGEST) criteria: validation of DIGEST version 2","volume":"128","author":"Hutcheson","year":"2022","journal-title":"Cancer."},{"key":"2026041213035864400_ref27","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1007\/s00455-008-9185-9","article-title":"MBS measurement tool for swallow impairment\u2014MBSImp: establishing a standard","volume":"23","author":"Martin-Harris","year":"2008","journal-title":"Dysphagia."},{"issue":"4","key":"2026041213035864400_ref28","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s00455-017-9809-z","article-title":"Use of the penetration-aspiration scale in dysphagia research: a systematic review","volume":"35","author":"Borders","year":"2020","journal-title":"Dysphagia."},{"issue":"4","key":"2026041213035864400_ref29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/dote\/doaf054","article-title":"The prevalence, nature and severity of oropharyngeal dysphagia in the acute post-operative phase following curative resection for esophageal cancer","volume":"38","author":"Hayes","year":"2025","journal-title":"Dis Esophagus"},{"issue":"1","key":"2026041213035864400_ref30","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/nyas.13150","article-title":"Oropharyngeal and laryngeal sensory innervation in the pathophysiology of swallowing disorders and sensory stimulation treatments","volume":"1380","author":"Alvarez-Berdugo","year":"2016","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"2026041213035864400_ref31","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1002\/ags3.12839","article-title":"Preoperative geniohyoid muscle mass in esophageal cancer patients is associated with swallowing function after esophagectomy","volume":"8","author":"Kawata","year":"2024","journal-title":"Annals of Gastroenterological Surgery"},{"issue":"24","key":"2026041213035864400_ref32","doi-asserted-by":"publisher","first-page":"7611","DOI":"10.3390\/jcm13247611","article-title":"Prevention and Management of Recurrent Laryngeal Nerve Palsy in minimally invasive Esophagectomy: current status and future perspectives","volume":"13","author":"Taniyama","year":"2024","journal-title":"J Clin Med"},{"issue":"3","key":"2026041213035864400_ref33","first-page":"501","article-title":"Complications after esophagectomy","volume":"99","author":"Mboumi","year":"2019","journal-title":"Surgical Clinics"},{"key":"2026041213035864400_ref34","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/978-3-031-39086-9","volume-title":"Esophageal Cancer: Diagnosis and Treatment","author":"Bryan","year":"2023"},{"issue":"4","key":"2026041213035864400_ref35","doi-asserted-by":"publisher","first-page":"397","DOI":"10.5056\/jnm24003","article-title":"Coordination of pharyngeal and esophageal phases of swallowing","volume":"30","author":"Lang","year":"2024","journal-title":"Journal of Neurogastroenterology and Motility"},{"issue":"9","key":"2026041213035864400_ref36","doi-asserted-by":"publisher","first-page":"6419","DOI":"10.1245\/s10434-025-17709-8","article-title":"Risk factors for dysphagia after Oesophagectomy in oesophageal cancer patients: a systematic review and meta-analysis","volume":"32","author":"Su","year":"2025","journal-title":"Ann Surg Oncol"},{"key":"2026041213035864400_ref37","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.physbeh.2015.05.004","article-title":"Coordination in oro-pharyngeal biomechanics during human swallowing","volume":"147","author":"Li","year":"2015","journal-title":"Physiol Behav"},{"issue":"2","key":"2026041213035864400_ref38","doi-asserted-by":"publisher","first-page":"393","DOI":"10.2214\/ajr.178.2.1780393","article-title":"Videofluoroscopic assessment of patients with dysphagia: pharyngeal retention is a predictive factor for aspiration","volume":"178","author":"Eisenhuber","year":"2002","journal-title":"Am J Roentgenol"},{"issue":"5","key":"2026041213035864400_ref39","doi-asserted-by":"publisher","first-page":"doae003","DOI":"10.1093\/dote\/doae003","article-title":"Nature, severity, and impact of chronic oropharyngeal dysphagia following curative resection for esophageal cancer: a cross-sectional study","volume":"37","author":"Gillman","year":"2024","journal-title":"Dis Esophagus"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/39\/2\/doag029\/68018782\/doag029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/39\/2\/doag029\/68018782\/doag029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T17:04:06Z","timestamp":1776013446000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article\/doi\/10.1093\/dote\/doag029\/8650474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3,2]]}},"URL":"https:\/\/doi.org\/10.1093\/dote\/doag029","relation":{},"ISSN":["1442-2050"],"issn-type":[{"value":"1442-2050","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,3,2]]},"article-number":"doag029"}}