{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:55:37Z","timestamp":1791219337133,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High-resolution esophageal manometry (HRM) allows for precise evaluation of esophageal motor abnormalities in patients with systemic sclerosis (SSc), but data from Latin America are limited. The aim of this study was to determine the prevalence and clinical predictors of esophageal motor dysfunction in patients with SSc, using the Chicago Classification from 2010 to 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cross-sectional study including adult patients with a confirmed diagnosis of SSc who underwent HRM between 2010 and 2022. Studies were performed using Sandhill Scientific (now Diversatek Healthcare) or Medtronic systems and interpreted according to the version of the Chicago Classification available at the time. Esophageal motor function was categorized as absent contractility, ineffective esophageal motility, or normal motility. Demographic, clinical, and serological data were collected from medical records. Logistic regression was used to identify predictors, and a clinical prediction score was developed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 127 patients (mean age 56\u00a0years, 93% female), 73% had esophageal motor dysfunction. In multivariable analysis, the presence of regurgitation, digital pitting scars, and diffusion capacity for carbon monoxide \u226480% were independently associated with motor dysfunction. A clinical prediction score combining these three factors stratified the probability of esophageal involvement from 40.9% (score 0) to 93.8% (score 3). The model showed good performance in terms of discrimination and calibration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Esophageal motor dysfunction is highly prevalent in patients with SSc and can be predicted using simple clinical variables. This tool may help guide diagnostic evaluation, particularly in healthcare settings with limited access to esophageal manometry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/dote\/doag031","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T12:38:44Z","timestamp":1773751124000},"source":"Crossref","is-referenced-by-count":1,"title":["Esophageal motor dysfunction in systemic sclerosis: clinical predictors and a risk stratification model"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8616-3457","authenticated-orcid":false,"given":"Maria Marta","family":"Piskorz","sequence":"first","affiliation":[{"name":"Neurogastroenterology Section. Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn\u201d , , CABA, Buenos Aires ,","place":["Argentina"]},{"name":"University of Buenos Aires , , CABA, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jose","family":"Lopez Meiller","sequence":"additional","affiliation":[{"name":"Rheumatology Section. Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn\u201d , , CABA, Buenos Aires ,","place":["Argentina"]},{"name":"University of Buenos Aires , , CABA, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Khoury","sequence":"additional","affiliation":[{"name":"Scientific Advisory Section, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn\u201d , , CABA, Buenos Aires ,","place":["Argentina"]},{"name":"University of Buenos Aires , , CABA, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Tamborenea","sequence":"additional","affiliation":[{"name":"Rheumatology Section. Hospital Rivadavia. CABA, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julieta","family":"Morbiducci","sequence":"additional","affiliation":[{"name":"Rheumatology Section. Hospital Rivadavia. CABA, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aixa","family":"Merce","sequence":"additional","affiliation":[{"name":"Rheumatology Section. Hospital Rivadavia. CABA, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Uehara","sequence":"additional","affiliation":[{"name":"Neurogastroenterology Section. Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn\u201d , , CABA, Buenos Aires ,","place":["Argentina"]},{"name":"University of Buenos Aires , , CABA, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Tevez","sequence":"additional","affiliation":[{"name":"Neurogastroenterology Section. Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn\u201d , , CABA, Buenos Aires ,","place":["Argentina"]},{"name":"University of Buenos Aires , , CABA, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Arias","sequence":"additional","affiliation":[{"name":"Rheumatology Section. Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn\u201d , , CABA, Buenos Aires ,","place":["Argentina"]},{"name":"University of Buenos Aires , , CABA, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Gonzalez Ballerga","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn\u201d , , CABA, Buenos Aires ,","place":["Argentina"]},{"name":"University of Buenos Aires , , CABA, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A","family":"Olmos","sequence":"additional","affiliation":[{"name":"Neurogastroenterology Section. Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn\u201d , , CABA, Buenos Aires ,","place":["Argentina"]},{"name":"University of Buenos Aires , , CABA, Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"2026041702362993500_ref1","doi-asserted-by":"crossref","first-page":"15002","DOI":"10.1038\/nrdp.2015.2","article-title":"Systemic sclerosis","volume":"1","author":"Allanore","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"2026041702362993500_ref2","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1136\/ard.2009.114264","article-title":"Causes and risk factors for death in systemic sclerosis: a study from the EULAR scleroderma trials and research (EUSTAR) database","volume":"69","author":"Tyndall","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"2026041702362993500_ref3","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/ard.2006.066068","article-title":"Changes in causes of death in systemic sclerosis, 1972-2002","volume":"66","author":"Steen","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"2026041702362993500_ref4","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: an ACR-EULAR collaborative initiative","volume":"65","author":"Van Den Hoogen","year":"2013","journal-title":"Arthritis Rheum"},{"key":"2026041702362993500_ref5","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1136\/annrheumdis-2019-eular.6743","article-title":"Tracking impact of interstitial lung disease in systemic sclerosis in a national cohort","volume":"78","author":"Hoffmann-Vold","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"2026041702362993500_ref6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/1529-0131(200108)45:4<346::AID-ART347>3.0.CO;2-L","article-title":"Esophageal involvement and pulmonary manifestations in systemic sclerosis","volume":"45","author":"Marie","year":"2001","journal-title":"Arthritis Rheum"},{"key":"2026041702362993500_ref7","first-page":"5787","article-title":"Gastroesophageal reflux and pulmonary fibrosis in scleroderma: a possible bidirectional relationship","volume":"19","author":"Savarino","year":"2013","journal-title":"World J Gastroenterol"},{"key":"2026041702362993500_ref8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11926-011-0217-3","article-title":"Gastrointestinal manifestations of scleroderma: recent progress in evaluation, pathogenesis, and management","volume":"14","author":"Gyger","year":"2012","journal-title":"Curr Rheumatol Rep"},{"key":"2026041702362993500_ref9","volume":"33","journal-title":"Neurogastroenterol Motil"},{"key":"2026041702362993500_ref10","first-page":"8","article-title":"Consenso Latinoamericano de motilidad esof\u00e1gica","volume":"50","author":"Olmos","year":"2020","journal-title":"Acta Gastroenterol Latinoam"},{"key":"2026041702362993500_ref11","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/nmo.12813","article-title":"The association between systemic sclerosis disease manifestations and esophageal high-resolution manometry parameters","volume":"28","author":"Kimmel","year":"2016","journal-title":"Neurogastroenterol Motil"},{"key":"2026041702362993500_ref12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cgh.2016.08.034","article-title":"Esophageal motor abnormalities in patients with scleroderma: heterogeneity, risk factors, and effects on quality of life","volume":"15","author":"Crowell","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026041702362993500_ref13","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1002\/acr.25080","article-title":"Associations between patterns of esophageal dysmotility and extra-intestinal features in patients with systemic sclerosis","volume":"75","author":"Tucker","year":"2023","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2026041702362993500_ref14","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s10067-018-4026-1","article-title":"Esophageal high-resolution impedance manometry alterations in asymptomatic patients with systemic sclerosis: prevalence, associations with disease features, and prognostic value","volume":"37","author":"Vettori","year":"2018","journal-title":"Clin Rheumatol"},{"key":"2026041702362993500_ref15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.5301\/jsrd.5000233","article-title":"Association between clinical manifestations of systemic sclerosis and esophageal dysmotility assessed by high-resolution manometry","volume":"2","author":"Carlan","year":"2017","journal-title":"J Scleroderma Relat Disord"},{"key":"2026041702362993500_ref16","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.cgh.2016.03.039","article-title":"Loss of peristaltic reserve, determined by multiple rapid swallows, is the most frequent esophageal motility abnormality in patients with systemic sclerosis","volume":"14","author":"Carlson","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026041702362993500_ref17","article-title":"Esophageal symptoms and their lack of association with high-resolution manometry in systemic sclerosis patients","volume-title":"Reumatol Clin (Engl Ed)","author":"Arana-Guajardo"},{"key":"2026041702362993500_ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/dote\/dox067","article-title":"Spectrum of esophageal dysmotility in systemic sclerosis on high-resolution esophageal manometry as defined by Chicago classification","volume":"30","author":"Aggarwal","year":"2017","journal-title":"Dis Esophagus"},{"key":"2026041702362993500_ref19","first-page":"826","article-title":"Distal esophageal functional abnormalities using high-resolution manometry with esophageal pressure topography: clustering analysis of 400 patients","volume":"22","author":"Pandolfino","year":"2010","journal-title":"Neurogastroenterol Motil"},{"key":"2026041702362993500_ref20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1365-2982.2011.01834.x","article-title":"Chicago classification criteria of esophageal motility disorders defined in high resolution esophageal pressure topography (EPT)","volume":"24","author":"Bredenoord","year":"2012","journal-title":"Neurogastroenterol Motil"},{"key":"2026041702362993500_ref21","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/nmo.12477","article-title":"The Chicago classification of esophageal motility disorders, v3.0","volume":"27","author":"Kahrilas","year":"2015","journal-title":"Neurogastroenterol Motil"},{"key":"2026041702362993500_ref22","article-title":"Systematic review of pharyngeal and Esophageal manometry in healthy or dysphagic older persons (&gt;60 years)","volume":"3","author":"Cock","journal-title":"Geriatrics (Basel)"},{"key":"2026041702362993500_ref23","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1007\/s10067-024-07025-z","article-title":"Late-age onset systemic sclerosis-clinical and serological characteristics","volume":"43","author":"Wielosz","year":"2024","journal-title":"Clin Rheumatol"},{"key":"2026041702362993500_ref24","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.1093\/rheumatology\/keac118","article-title":"Gastrointestinal symptom severity and progression in systemic sclerosis","volume":"61","author":"Leeuwen","year":"2022","journal-title":"Rheumatology (Oxford)"},{"key":"2026041702362993500_ref25","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1093\/rheumatology\/keae469","article-title":"Distinct clinical trajectories of gastrointestinal progression among patients with systemic sclerosis","volume":"64","author":"Perin","year":"2025","journal-title":"Rheumatology (Oxford)"},{"key":"2026041702362993500_ref26","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.12998\/wjcc.v9.i22.6201","article-title":"Gastrointestinal manifestations of systemic sclerosis: an updated review","volume":"9","author":"Luquez-Mindiola","year":"2021","journal-title":"World J Clin Cases"},{"key":"2026041702362993500_ref27","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/acr.24488","article-title":"Relationship between gastrointestinal transit, Medsger gastrointestinal severity, and University of California-los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract 2.0 symptoms in patients with systemic sclerosis","volume":"74","author":"McMahan","year":"2022","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2026041702362993500_ref28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.semarthrit.2010.03.002","article-title":"Gastroesophageal reflux incites interstitial lung disease in systemic sclerosis: clinical, radiologic, histopathologic, and treatment evidence","volume":"40","author":"Christmann","year":"2010","journal-title":"Semin Arthritis Rheum"},{"key":"2026041702362993500_ref29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5056\/jnm15177","article-title":"Clinical application of esophageal high-resolution manometry in the diagnosis of esophageal motility disorders","volume":"22","author":"Hoeij","year":"2016","journal-title":"J Neurogastroenterol Motil"},{"key":"2026041702362993500_ref30","volume":"73","journal-title":"Arthritis Rheumatol"},{"key":"2026041702362993500_ref31","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.semarthrit.2017.05.005","article-title":"High-resolution manometry compared with the University of California, los Angeles scleroderma clinical trials consortium GIT 2.0 in systemic sclerosis","volume":"47","author":"Abozaid","year":"2017","journal-title":"Semin Arthritis Rheum"},{"key":"2026041702362993500_ref32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1442-2050.2010.01150.x","article-title":"Esophageal dysmotility associated with systemic sclerosis: a high-resolution manometry study","volume":"24","author":"Roman","year":"2011","journal-title":"Dis Esophagus"},{"key":"2026041702362993500_ref33","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1442-2050.2012.01349.x","article-title":"Symptoms and esophageal motility based on phenotypic findings of scleroderma","volume":"26","author":"Tang","year":"2013","journal-title":"Dis Esophagus"},{"issue":"Suppl 100","key":"2026041702362993500_ref34","first-page":"63","article-title":"Esophageal and anorectal involvement in systemic sclerosis: a systematic assessment with high resolution manometry","volume":"34","author":"Luciano","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"2026041702362993500_ref35","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10067-019-04794-w","article-title":"The role of high-resolution manometry in the assessment of upper gastrointestinal involvement in systemic sclerosis: a systematic review","volume":"39","author":"Schutyser","year":"2020","journal-title":"Clin Rheumatol"},{"key":"2026041702362993500_ref36","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1136\/annrheumdis-2024-eular.5528","article-title":"Ab1211 esophageal involvement and correlations with patient characteristics in systemic sclerosis (monocentric study)","volume":"83","author":"Annunziata","year":"2024","journal-title":"Ann Rheum Dis"},{"key":"2026041702362993500_ref37","volume-title":"Arthritis Care Res (Hoboken)"},{"key":"2026041702362993500_ref38","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/BOR.0000000000000117","article-title":"Evaluation and management of gastrointestinal manifestations in scleroderma","volume":"26","author":"Kirby","year":"2014","journal-title":"Curr Opin Rheumatol"},{"key":"2026041702362993500_ref39","doi-asserted-by":"crossref","first-page":"186","DOI":"10.5301\/jsrd.5000207","article-title":"Emerging strategies for treatment of systemic sclerosis","volume":"1","author":"Khanna","year":"2016","journal-title":"J Scleroderma Relat Disord"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/39\/2\/doag031\/68024010\/doag031.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/39\/2\/doag031\/68024010\/doag031.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:36:44Z","timestamp":1776407804000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article\/doi\/10.1093\/dote\/doag031\/8651032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3,2]]}},"URL":"https:\/\/doi.org\/10.1093\/dote\/doag031","relation":{},"ISSN":["1442-2050"],"issn-type":[{"value":"1442-2050","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,3,2]]},"article-number":"doag031"}}