{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T22:49:48Z","timestamp":1777762188202,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":58,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The incidence of esophageal cancer resections is rising, and survivorship improving. Consequently, more patients are living longer with gastric conduits and enduring the associated morbidity. Gastric conduit shape and peristalsis are believed to mediate conduit function, gastrointestinal symptoms, and quality of life (QoL). However, the relationship between anatomical variations, peristaltic function, and conduit emptying remains largely undefined. This prospective observational study recruited patients with gastric conduits at least 2\u00a0years post-esophagectomy and controls with normal gastric anatomy. Dynamic and static MRI sequences were obtained following porridge ingestion. Nuclear scintigraphy conduit emptying studies were available for 17 out of 18 (94%) patients. QoL questionnaire data were collected. Eighteen patients with conduits and 12 controls were recruited. Peristalsis was measurable in 15 conduits. There was no difference in peristaltic wave frequency between conduits and controls (5 waves per 90\u00a0seconds in each group) or median Gastric Motility Index Interquartile Range (IQR) 35.45\u00a0mm2\/second (17.3\u201347.5) vs 36.5\u00a0mm2\/second (9.8\u201399.4) p\u2009=\u20090.61. Gastric emptying was significantly reduced in conduit patients (0.10% vs 15% p\u2009=\u20090.01). Acute angulation and conduits wider than 4\u00a0cm were associated with slower emptying (444\u00a0minutes vs 127\u00a0minutes, p\u2009=\u20090.025) and (286\u00a0minutes vs 76\u00a0minutes, p\u2009=\u20090.02), respectively. Delayed emptying demonstrated a significant positive correlation with reflux (rs0.614, p\u2009=\u20090.009) and increased gastrointestinal symptoms (rs0.553, p\u2009=\u20090.021). Peristalsis is present in most conduits, but it does not correlate with improved emptying. Anatomical features, particularly conduit angulation and width influence conduit function. These findings may guide further research into optimizing conduit formation and treating dysfunction.<\/jats:p>","DOI":"10.1093\/dote\/doag045","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:41:59Z","timestamp":1776253319000},"source":"Crossref","is-referenced-by-count":0,"title":["Peristalsis of the gastric conduit post-esophagectomy: is it relevant? Detailed conduit analysis using dynamic magnetic resonance imaging"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0109-0258","authenticated-orcid":false,"given":"Kaleb","family":"Lourensz","sequence":"first","affiliation":[{"name":"Department of Surgery - Central Clinical School, Monash University , Melbourne ,","place":["Australia"]},{"name":"Department of General Surgery - Oesophago-gastric and Bariatric Unit, The Alfred Hospital , Melbourne ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anagi","family":"Wickremasinghe","sequence":"additional","affiliation":[{"name":"Department of Surgery - Central Clinical School, Monash University , Melbourne ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalini","family":"Bigwood","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, The Alfred Hospital , Melbourne ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazmin","family":"Johari","sequence":"additional","affiliation":[{"name":"Department of General Surgery - Oesophago-gastric and Bariatric Unit, The Alfred Hospital , Melbourne ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Beech","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, The Alfred Hospital , Melbourne ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff","family":"Hebbard","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Royal Melbourne Hospital and University of Melbourne , Melbourne ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Burton","sequence":"additional","affiliation":[{"name":"Department of Surgery - Central Clinical School, Monash University , Melbourne ,","place":["Australia"]},{"name":"Department of General Surgery - Oesophago-gastric and Bariatric Unit, The Alfred Hospital , Melbourne ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy A","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Surgery - Central Clinical School, Monash University , Melbourne ,","place":["Australia"]},{"name":"Department of General Surgery - Oesophago-gastric and Bariatric Unit, The Alfred Hospital , Melbourne ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"2026042910260233100_ref1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.thorsurg.2006.01.002","article-title":"Functional conduit disorders after esophagectomy","volume":"16","author":"Donington","year":"2006","journal-title":"Thorac Surg 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