{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:54:12Z","timestamp":1781826852749,"version":"3.54.5"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>One method to improve visualization of the thoracic duct (TD) during surgery is to improve its identification through the application of indocyanine green (ICG). The primary objective of this study was to verify whether the application of indocyanine green via parenteral injection improved visualization of the TD during minimally invasive esophagectomy (MIE) with patients in the prone position. This is the first study authorized by the Italian Medicines Agency (AIFA) with Eudra CT 2019\u2013004374-25.<\/jats:p>\n                  <jats:p>In this study, 0.5\u00a0mg\/kg of ICG reconstituted in 10\u00a0mL of water for injection was injected percutaneously into the germinal center of bilateral superficial inguinal lymph nodes in each patient prior to thoracoscopy in total and subtotal esophagectomy. KARL STORZ OPAL1\u00ae technology was used for NIR imaging with ICG.<\/jats:p>\n                  <jats:p>The TD was clearly identified in all fifty-two patients in whom transthoracic esophagectomy was feasible. No adverse reactions to the ICG injection occurred. We had one postoperative chylothorax.<\/jats:p>\n                  <jats:p>NIR-ICG imaging during minimally invasive esophagectomy is highly effective in identifying the thoracic duct.<\/jats:p>\n                  <jats:p>Given the number of cases and the visualization rate, we conclude that the procedure could be used in esophageal surgery and could significantly reduce the rate of postoperative chylothorax.<\/jats:p>","DOI":"10.1093\/dote\/doag057","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T11:40:07Z","timestamp":1779968407000},"source":"Crossref","is-referenced-by-count":0,"title":["VERDEDT 1.0: five years single-center experience with real-time indocyanine green fluorescence imaging of the thoracic duct during minimally invasive esophagectomy"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9653-9358","authenticated-orcid":false,"given":"Antonio","family":"Martino","sequence":"first","affiliation":[{"name":"Department of Surgery , ASUFC \u201cSanta Maria della Misericordia\u201d, Piazzale SM della Misericordia 15, Udine, I-33100 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Petri","sequence":"additional","affiliation":[{"name":"Department of Surgery , ASUFC \u201cSanta Maria della Misericordia\u201d, Piazzale SM della Misericordia 15, Udine, I-33100 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Uzzau","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Udine , Udine, I-33100 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Del Favero","sequence":"additional","affiliation":[{"name":"Department of Surgery , Surgical High-dependency Unit, ASUFC \u201cSanta Maria della Misericordia\u201d, Piazzale SM della Misericordia 15, Udine, I-33100 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ziccarelli","sequence":"additional","affiliation":[{"name":"Department of Surgery , ASUFC \u201cSanta Maria della Misericordia\u201d, Piazzale SM della Misericordia 15, Udine, I-33100 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Rossit","sequence":"additional","affiliation":[{"name":"Department of Surgery , ASUFC \u201cSanta Maria della Misericordia\u201d, Piazzale SM della Misericordia 15, Udine, I-33100 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Santangelo","sequence":"additional","affiliation":[{"name":"Department of Surgery , ASUFC \u201cSanta Maria della Misericordia\u201d, Piazzale SM della Misericordia 15, Udine, I-33100 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Deana","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care , Health Integrated Agency of Friuli Centrale, Udine, I-33100 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Vecchiato","sequence":"additional","affiliation":[{"name":"Department of Surgery , ASUFC \u201cSanta Maria della Misericordia\u201d, Piazzale SM della Misericordia 15, Udine, I-33100 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"2026061819372351800_ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/dote\/doaa030","article-title":"Thoracic duct identification with indocyanine green fluorescence during minimally invasive esophagectomy with patient in prone position","volume":"33","author":"Vecchiato","year":"2020","journal-title":"Disease of the Esophagus"},{"issue":"1","key":"2026061819372351800_ref2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.5090\/jcs.24.091","article-title":"Real-time fluorescence imaging for thoracic Duc identification during Oesophagectomy: a systematic review of the literature","volume":"58","author":"Peristeri","year":"2025","journal-title":"J Chest Surg"},{"key":"2026061819372351800_ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.912351","article-title":"Fluorescence-guided identification of the thoracic duct by VATS for treatment of postoperative chylothorax: a short case series","volume":"9","author":"Londero","year":"2022","journal-title":"Front Surg"},{"issue":"3","key":"2026061819372351800_ref4","doi-asserted-by":"publisher","first-page":"e2380","DOI":"10.1002\/rcs.2380","article-title":"Fluorescent lymphography for thoracic duct identification: initial experience of a simplified and feasible ICG administration","volume":"18","author":"Barbato","year":"2022","journal-title":"Int J Med robot"},{"issue":"05","key":"2026061819372351800_ref5","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1055\/s-0037-1602259","article-title":"(2018) effect of prophylactic thoracic duct ligation in reducing the incidence of postoperative chylothorax during esophagectomy: a systematic review and meta-analysis","volume":"66","author":"Yiyan","year":"2018","journal-title":"Thorac Cardiovasc Surg"},{"issue":"12","key":"2026061819372351800_ref6","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1007\/s11748-009-0483-4","article-title":"Magnetic resonance-thoracic ductography: imaging aid for thoracic surgery and thoracic duct depiction based on embryological considerations","volume":"57","author":"Okuda","year":"2009","journal-title":"Gen Thorac Cardiovasc Surg"},{"issue":"6","key":"2026061819372351800_ref7","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3390\/cancers17060967","article-title":"Resection vs. ligation vs. preservation of the thoracic duct during esophagectomy for cancer: a systematic review and meta-analysis","volume":"17","author":"Nijssen","year":"2025","journal-title":"Cancers (Basel)"},{"key":"2026061819372351800_ref8","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s12893-025-03113-2","article-title":"Application of fat meal in thoracic duct outlet obstruction reconstruction surgery","volume":"25","author":"Jiang","year":"2025","journal-title":"BMC Surg"}],"container-title":["Diseases of the 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