{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:53:57Z","timestamp":1782125637988,"version":"3.54.5"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>New-onset atrial fibrillation (NOAF) is a frequent complication after esophagectomy. While associated with adverse short-term outcomes, its longer-term cardiovascular impact remains uncertain. We evaluated associations between NOAF and postoperative cardiovascular and respiratory complications using a large international real-world dataset. We performed a retrospective cohort study using the TriNetX global federated health research network. Adults undergoing esophagectomy were identified using ICD-10, CPT, and SNOMED codes, excluding those with prior atrial fibrillation or flutter. NOAF was defined within 30\u00a0days postoperatively. Propensity score matching (1:1) balanced demographics, comorbidities, and medication use. Outcomes were assessed over 12\u00a0months using Cox proportional hazards models. We analyzed 1977 matched patients (mean age 67.1\u2009\u00b1\u20098.7\u00a0years; 18% female). Within 0\u20133\u00a0months, NOAF was associated with increased risks of death (HR 2.09, 95% CI 1.62\u20132.70), heart failure (HR 2.03, 95% CI 1.32\u20133.11), myocardial infarction (HR 2.35, 95% CI 1.17\u20134.74), pneumonia (HR 1.80, 95% CI 1.42\u20132.29), venous thromboembolism (HR 1.76, 95% CI 1.17\u20132.66), and rehospitalization (HR 2.78, 95% CI 2.42\u20133.20), with no significant association for stroke. Between 3 and 12\u00a0months, elevated risks persisted for death (HR 1.60, 95% CI 1.30\u20131.98) and heart failure (HR 2.55, 95% CI 1.37\u20134.73). Across 12\u00a0months, NOAF remained associated with death (HR 1.76, 95% CI 1.50\u20132.07) and heart failure (HR 2.23, 95% CI 1.56\u20133.19). NOAF after esophagectomy identifies patients at increased risk of major postoperative and cardiovascular complications, particularly early after surgery.<\/jats:p>","DOI":"10.1093\/dote\/doag058","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T11:21:02Z","timestamp":1780312862000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of new-onset atrial fibrillation on 12-month outcomes and mortality after esophagectomy"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9445-2582","authenticated-orcid":false,"given":"Hani","family":"Essa","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool ,","place":["UK"]},{"name":"Royal Liverpool Intensive Care Unit, University Hospitals of Liverpool Group , Liverpool ,","place":["UK"]},{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , Liverpool ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin","family":"Balu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool ,","place":["UK"]},{"name":"Royal Liverpool Intensive Care Unit, University Hospitals of Liverpool Group , Liverpool ,","place":["UK"]},{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , Liverpool ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool ,","place":["UK"]},{"name":"Royal Liverpool Intensive Care Unit, University Hospitals of Liverpool Group , Liverpool ,","place":["UK"]},{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , Liverpool ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Upper Gastrointestinal Surgery, Royal Liverpool University Hospital , Liverpool ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y H","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , Liverpool ,","place":["UK"]},{"name":"Department of Clinical Medicine, Aalborg University , Aalborg ,","place":["Denmark"]},{"name":"Department of Cardiology, Lipidology and Internal Medicine, Medical University of Bialystok , Bialystok ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg","family":"Welters","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool ,","place":["UK"]},{"name":"Royal Liverpool Intensive Care Unit, University Hospitals of Liverpool Group , Liverpool ,","place":["UK"]},{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , Liverpool ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"issue":"1","key":"2026062206410264500_ref1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/1759-7714.14745","article-title":"Epidemiology of 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