{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T08:22:00Z","timestamp":1787473320215,"version":"build-2736575974"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Squamous cell carcinoma antigen (SCC-Ag) and carcinoembryonic antigen (CEA) are routinely monitored after definitive chemoradiotherapy (dCRT) for esophageal squamous cell carcinoma (ESCC) in Japan, but their clinical significance remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from patients with resectable ESCC treated with dCRT in the JCOG0502 and JCOG0909 trials, who underwent intensive protocolized surveillance with computed tomography (CT), esophagogastroduodenoscopy (EGD), SCC-Ag, and CEA. Tumor marker positivity was defined as exceeding the cut-off value at least once, at two consecutive measurements, or at three consecutive measurements during follow-up. Sensitivity and specificity were calculated for SCC-Ag and CEA at 0.1-ng\/mL increments to determine whether any cut-off met the predefined performance criteria (sensitivity \u226560% and specificity \u226570%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 239 patients (stage I\/II\/III\u2009=\u2009147\/58\/34 [UICC 6th edition]), among whom 38% (91\/239) experienced disease progression or recurrence. The median baseline SCC-Ag and CEA levels were 1.0\u00a0ng\/mL (interquartile range [IQR], 0.8\u20131.5) and 2.3\u00a0ng\/mL (IQR, 1.6\u20133.6), respectively, with a median of 16 measurements each (IQR, 8\u201319 for SCC-Ag; 8\u201320 for CEA). The highest specificities with sensitivity \u226560% were 19.6% for SCC-Ag (cut-off, 1.5\u00a0ng\/mL) and 20.3% for CEA (cut-off, 2.2\u00a0ng\/mL), but neither met the predefined criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this pooled cohort of patients with resectable ESCC who underwent dCRT and intensive protocolized CT and EGD surveillance, routine SCC-Ag and CEA monitoring showed limited incremental diagnostic value. The relevance of these findings to higher-risk cohorts and less intensive surveillance settings warrants further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/dote\/doag072","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:26:45Z","timestamp":1783978005000},"source":"Crossref","is-referenced-by-count":0,"title":["Squamous cell carcinoma antigen and carcinoembryonic antigen monitoring during post-definitive chemoradiotherapy surveillance for esophageal squamous cell carcinoma: JCOG2106A"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1590-0250","authenticated-orcid":false,"given":"Katsuyuki","family":"Sakanaka","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1733-5072","authenticated-orcid":false,"given":"Ken","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Head and Neck, Esophageal Medical Oncology, National Cancer Center Hospital , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryunosuke","family":"Machida","sequence":"additional","affiliation":[{"name":"National Cancer Center Hospital, Japan Clinical Oncology Group Data Center\/Operations Office , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Showa University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9562-2966","authenticated-orcid":false,"given":"Hiroyuki","family":"Daiko","sequence":"additional","affiliation":[{"name":"Department of Esophageal Surgery, National Cancer Center Hospital , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kajiwara","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology, National Hospital Organization Shikoku Cancer Center , Ehime ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Tsubosa","sequence":"additional","affiliation":[{"name":"Division of Esophageal Surgery, Shizuoka Cancer Center Hospital , Shizuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Minashi","sequence":"additional","affiliation":[{"name":"Clinical Trial Promotion Department, Chiba Cancer Center , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6976-9753","authenticated-orcid":false,"given":"Tetsuya","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Aichi Cancer Center Hospital , Aichi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Saitama Cancer Center , Saitama 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