{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:51:00Z","timestamp":1791838260850,"version":"4.3.4"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>A 96-hour ambulatory pH testing is a practical tool for diagnosing gastroesophageal reflux disease (GERD) and for concurrently evaluating two conditions: dietary variation and its effect on measured acid exposure time (AET) and reported symptoms. To date, it is unknown how consuming a diet of either low or high acidity can influence pathologic GERD. This study aimed to assess the effects of high- and low-acid diets on AET and the occurrence of laryngopharyngeal symptoms (LPS) during prolonged wireless pH monitoring. A retrospective review of 208 patients who underwent 96-hour wireless pH monitoring for GERD evaluation was completed. Patients consumed a primarily high-acid diet on 1 day and a primarily low-acid diet on a separate day during the 96-hour period. Patients were considered to have pathologic GERD if esophageal AET was &amp;gt;6% for the time with pH &amp;lt;4, and were considered normal on an individual day if the AET was &amp;lt;4%. Pathologic GERD was found in 78 patients (37.5%), of whom the majority (55%) recorded their lowest AET during the study on their low-acid day. Only 24.7% achieved normal AET on a low-acid diet day. Mean AET on a high-acid diet, compared with a low-acid diet, decreased by 41%, from 12.51 to 7.33, with a similarly proportional decrease in patients negative for GERD. There was no significant difference between patients with and without LPS with regard to esophageal acid exposure on high- and low-acid diet days (P\u2009=\u20090.73, P\u2009=\u20090.81). A low-acid diet may be a viable lifestyle modification when used as monotherapy or adjunctively with proton pump inhibitor in patients with or without pathologic GERD.<\/jats:p>","DOI":"10.1093\/dote\/doag085","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:19:48Z","timestamp":1785151188000},"source":"Crossref","is-referenced-by-count":1,"title":["A low-acid diet rarely normalizes pathologic gastroesophageal reflux disease"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5230-5029","authenticated-orcid":false,"given":"Anthony","family":"Skryd","sequence":"first","affiliation":[{"name":"Department of Medicine, NYU Langone Health , New York, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Pasuizaca-Yanez","sequence":"additional","affiliation":[{"name":"Center for Esophageal Health, Division of Gastroenterology and Hepatology, Department of Medicine, NYU Langone Health , New York, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreya","family":"Chablaney","sequence":"additional","affiliation":[{"name":"Center for Esophageal Health, Division of Gastroenterology and Hepatology, Department of Medicine, NYU Langone Health , New York, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Becker","sequence":"additional","affiliation":[{"name":"Center for Esophageal Health, Division of Gastroenterology and Hepatology, Department of Medicine, NYU Langone Health , New York, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Durkin","sequence":"additional","affiliation":[{"name":"Center for Esophageal Health, Division of Gastroenterology and Hepatology, Department of Medicine, NYU Langone Health , New York, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Rozier","sequence":"additional","affiliation":[{"name":"Center for Esophageal Health, Division of Gastroenterology and Hepatology, Department of Medicine, NYU Langone Health , New York, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Center for Esophageal Health, Division of Gastroenterology and Hepatology, Department of Medicine, NYU Langone Health , New York, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaritza","family":"Cruz","sequence":"additional","affiliation":[{"name":"Center for Esophageal Health, Division of Gastroenterology and Hepatology, Department of Medicine, NYU Langone Health , New York, 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