{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:57:15Z","timestamp":1790517435036,"version":"4.1.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Routine esophageal biopsies during pediatric esophagogastroduodenoscopy (EGD) are recommended by current guidelines, even in the absence of macroscopic abnormalities; however, their clinical value remains uncertain. We conducted a retrospective review of all diagnostic EGDs performed at our institute between January 2019 and December 2021, a period during which esophageal biopsies were routinely obtained. Endoscopic findings and histologic results were analyzed to determine the diagnostic yield and clinical impact of biopsies in patients with a normal-appearing esophagus. A total of 1400 procedures were included, of which 1279 (91.3%) demonstrated a normal macroscopic esophagus. Among these, histological inflammation was identified in 73 cases (5.7%). However, only 27 cases (2.1%) were considered clinically significant. These included eosinophilic esophagitis in 7 patients (0.5%) and nonspecific esophagitis in 20 patients (1.6%), all of whom were treated with proton pump inhibitors. The remaining cases represented histological findings without clinical consequences during follow-up. To conclude, routine esophageal biopsies in children and adolescents with a normal-appearing esophagus during EGD appear to have a low diagnostic yield and limited impact on clinical management.<\/jats:p>","DOI":"10.1093\/dote\/doag108","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:33:47Z","timestamp":1789673627000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical significance and natural history of esophageal histologic inflammation without macroscopic findings in children"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4837-0009","authenticated-orcid":false,"given":"Gil","family":"Berkovitch","sequence":"first","affiliation":[{"name":"The Pediatric Gastroenterology Institute, \u201cDana-Dwek\u201d Children\u2019s Hospital, Tel Aviv Sourasky University Medical Center (Ichilov) , Tel Aviv ,","place":["Israel"]},{"name":"Gray Faculty of Medicine and Health Sciences, Tel Aviv University , 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