{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:18:02Z","timestamp":1787008682774,"version":"build-2736575974"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"DOI":"10.1093\/dote\/dox039","type":"journal-article","created":{"date-parts":[[2017,7,22]],"date-time":"2017-07-22T08:05:05Z","timestamp":1500710705000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["Effect of alginate in patients with GERD hiatal hernia matters"],"prefix":"10.1093","volume":"30","author":[{"given":"R.","family":"Vardar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Keskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Valitova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bayrakci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,7,19]]},"reference":[{"key":"key\n\t\t\t\t20170829014351_bib1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S1542-3565(04)00288-5","article-title":"Effectiveness of proton pump inhibitors in nonerosive reflux disease","volume":"2","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20170829014351_bib2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1572-0241.2002.05532.x","article-title":"Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitis","volume":"97","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20170829014351_bib3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/gut.2007.145581","article-title":"Management of heartburn not responding to proton pump inhibitors","volume":"58","year":"2009","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170829014351_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2036.2004.02298.x","article-title":"An evaluation of the antireflux properties of sodium alginate by means of combined multichannel intraluminal impedance and pH-metry","volume":"21","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t20170829014351_bib5","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1136\/gut.2010.235630","article-title":"A novel reflux inhibitor lesogaberan (AZD3355) as add-on treatment in patients with GORD with persistent reflux symptoms despite proton pump inhibitor therapy: a randomised placebo-controlled trial","volume":"60","year":"2011","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170829014351_bib6","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1046\/j.1365-2036.2000.00759.x","article-title":"Review article: alginate-raft formulations in the treatment of heartburn and acid reflux","volume":"14","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t20170829014351_bib7","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1211\/jpp.61.08.0005","article-title":"The role of an alginate suspension on pepsin and bile acids - key aggressors in the gastric refluxate. Does this have implications for the treatment of gastro-oesophageal reflux disease?","volume":"61","year":"2009","journal-title":"J Pharm Pharmacol"},{"key":"key\n\t\t\t\t20170829014351_bib8","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1053\/gast.2001.27997","article-title":"Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal","volume":"121","year":"2001","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170829014351_bib9","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1365-2982.2009.01293.x","article-title":"The effect of gastric secretion on gastric physiology and emptying in the fasted and fed state assessed by magnetic resonance imaging","volume":"21","year":"2009","journal-title":"Neurogastroenterol Motil"},{"key":"key\n\t\t\t\t20170829014351_bib10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2036.2011.04678.x","article-title":"An alginate-antacid formulation (Gaviscon Double Action Liquid) can eliminate or displace the postprandial \u2018acid pocket\u2019 in symptomatic GERD patients","volume":"34","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t20170829014351_bib11","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.cgh.2013.04.046","article-title":"An alginate-antacid formulation localizes to the acid pocket to reduce acid reflux in patients with gastroesophageal reflux disease","volume":"11","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"Suppl 8A","key":"key\n\t\t\t\t20170829014351_bib12","first-page":"157S","article-title":"Combined multichannel intraluminal impedance and pH-metry: an evolving technique to measure type and proximal extent of gastroesophageal reflux","volume":"111","year":"2001","journal-title":"Am J Med"},{"key":"key\n\t\t\t\t20170829014351_bib13","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1097\/00042737-200409000-00002","article-title":"Acid, weakly acidic and non-acid gastro-oesophageal reflux: differences, prevalence and clinical relevance","volume":"16","year":"2004","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20170829014351_bib14","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/gut.2009.178061","article-title":"The position of the acid pocket as a major risk factor for acidic reflux in healthy subjects and patients with GORD","volume":"59","year":"2010","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170829014351_bib15","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/gut.45.2.172","article-title":"Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification","volume":"45","year":"1999","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170829014351_bib16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1136\/gut.40.2.167","article-title":"Multivariate analysis of pathophysiological factors in reflux oesophagitis","volume":"40","year":"1997","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170829014351_bib17","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/j.1572-0241.2001.03926.x","article-title":"Hiatal hernia size is the dominant determinant of esophagitis presence and severity in gastroesophageal reflux disease","volume":"96","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20170829014351_bib18","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1023\/A:1020580630594","article-title":"Acid reflux is a poor predictor for severity of erosive reflux esophagitis","volume":"47","year":"2002","journal-title":"Dig Dis Sci"},{"key":"key\n\t\t\t\t20170829014351_bib19","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/j.1442-2050.2012.01368.x","article-title":"Similar symptom patterns in gastroesophageal reflux patients with and without hiatal hernia","volume":"26","year":"2013","journal-title":"Dis Esophagus"},{"key":"key\n\t\t\t\t20170829014351_bib20","first-page":"1291","article-title":"The role of the Phrenico-Esophageal ligament in the lower esophageal sphincter","volume":"118","year":"1964","journal-title":"Surg Gynecol Obstet"},{"key":"key\n\t\t\t\t20170829014351_bib21","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/gut.44.4.476","article-title":"The effect of hiatus hernia on gastro-oesophageal junction pressure","volume":"44","year":"1999","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170829014351_bib22","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/S0016-5085(03)01210-1","article-title":"Esophagogastric junction opening during relaxation distinguishes nonhernia reflux patients, hernia patients, and normal subjects","volume":"125","year":"2003","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170829014351_bib23","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/00004836-198012000-00016","article-title":"24-hour pH monitoring in the study of gastroesophageal reflux","volume":"2","year":"1980","journal-title":"J Clin Gastroenterol"},{"key":"key\n\t\t\t\t20170829014351_bib24","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/0016-5085(91)80003-R","article-title":"Impairment of esophageal emptying with hiatal hernia","volume":"100","year":"1991","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170829014351_bib25","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0016-5085(87)90849-3","article-title":"Identification and mechanism of delayed esophageal acid clearance in subjects with hiatus hernia","volume":"92","year":"1987","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170829014351_bib26","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/ajg.2013.132","article-title":"The acid pocket: a target for treatment in reflux disease?","volume":"108","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20170829014351_bib27","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1136\/gut.2006.109421","article-title":"Severe reflux disease is associated with an enlarged unbuffered proximal gastric acid pocket","volume":"57","year":"2008","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170829014351_bib28","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/apt.12318","article-title":"Post-prandial reflux suppression by a raft-forming alginate (Gaviscon Advance) compared to a simple antacid documented by magnetic resonance imaging and pH-impedance monitoring: mechanistic assessment in healthy volunteers and randomised, controlled, double-blind study in reflux patients","volume":"37","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t20170829014351_bib29","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gut.2003.033290","article-title":"Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas reflux","volume":"53","year":"2004","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170829014351_bib30","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1053\/gast.2001.24841","article-title":"Acid, nonacid, and gas reflux in patients with gastroesophageal reflux disease during ambulatory 24-hour pH-impedance recordings","volume":"120","year":"2001","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170829014351_bib31","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.3748\/wjg.v18.i32.4371","article-title":"Alginate controls heartburn in patients with erosive and nonerosive reflux disease","volume":"18","year":"2012","journal-title":"World J Gastroenterol"},{"key":"key\n\t\t\t\t20170829014351_bib32","first-page":"434","article-title":"Bravo wireless versus catheter pH monitoring systems","volume":"55","year":"2006","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170829014351_bib33","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1038\/ajg.2011.276","article-title":"Esophageal acid exposure decreases intraluminal baseline impedance levels","volume":"106","year":"2011","journal-title":"Am J Gastroenterol"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/dote\/article-pdf\/30\/10\/1\/19636931\/dox039.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T01:43:58Z","timestamp":1503971038000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/dote\/article\/30\/10\/1\/4001302\/Effect-of-alginate-in-patients-with-GERD-hiatal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,19]]},"references-count":33,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,7,19]]},"published-print":{"date-parts":[[2017,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/dote\/dox039","relation":{},"ISSN":["1120-8694","1442-2050"],"issn-type":[{"value":"1120-8694","type":"print"},{"value":"1442-2050","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,19]]}}}