{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T09:49:07Z","timestamp":1781344147397,"version":"3.54.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T00:00:00Z","timestamp":1512691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K23 DK090073"],"award-info":[{"award-number":["K23 DK090073"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Eosinophil peroxidase is an eosinophil-specific, cytoplasmic protein stored in the secondary granules of eosinophils. While eosinophil peroxidase deposition is increased in the esophagus in eosinophilic esophagitis (EOE), its potential role as a peripheral marker is unknown. This study aims to examine the relationship between serum eosinophil peroxidase and esophageal eosinophilia in eosinophilic esophagitis. Prospectively collected serum from 19 subjects with incident EoE prior to treatment and 20 non-EoE controls were tested for serum eosinophil peroxidase, eosinophilic cationic protein, and eosinophil derived neurotoxin using ELISA. Matching esophageal tissue sections were stained and assessed for eosinophil peroxidase deposition using a histopathologic scoring algorithm. Mean peripheral blood absolute eosinophil counts in eosinophilic esophagitis subjects were significantly elevated compared to controls (363 vs. 195 cells\/\u03bcL,P\u00a0=\u00a00.008). Absolute median serum eosinophil peroxidase, eosinophil cationic protein, and eosinophil derived neurotoxin did not differ between groups; however, when normalized for absolute eosinophil counts, eosinophilic esophagitis subjects had significantly lower median eosinophil peroxidase levels (2.56 vs. 6.96 ng\/mL per eos\/\u03bcL,P\u00a0=\u00a00.002, AUC 0.79 (0.64, 0.94 95% CI)). Multivariate analysis demonstrated this relationship persisted after controlling for atopy. Esophageal biopsies from eosinophilic esophagitis subjects demonstrated marked eosinophil peroxidase deposition (median score 46 vs. 0,P\u00a0&amp;lt;\u00a00.0001). Normalized eosinophil peroxidase levels inversely correlated with esophageal eosinophil density (r\u00a0=\u00a0\u22120.41,P\u00a0=\u00a00.009). In contrast to marked tissue eosinophil degranulation, circulating eosinophils appear to retain their granule proteins in EoE. Investigations of normalized serum eosinophil peroxidase levels as a biomarker of EoE are ongoing.<\/jats:p>","DOI":"10.1093\/dote\/dox139","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T17:29:12Z","timestamp":1512754152000},"source":"Crossref","is-referenced-by-count":21,"title":["Normalized serum eosinophil peroxidase levels are inversely correlated with esophageal eosinophilia in eosinophilic esophagitis"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7586-4722","authenticated-orcid":false,"given":"B L","family":"Wright","sequence":"first","affiliation":[{"name":"Division of Allergy, Asthma and Clinical Immunology, Department of Medicine"},{"name":"Division of Pulmonology, Department of Pediatrics, Phoenix Children's Hospital, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S I","family":"Ochkur","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N S","family":"Olson","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K P","family":"Shim","sequence":"first","affiliation":[{"name":"Division of Pulmonology, Department of Pediatrics, Phoenix Children's Hospital, Phoenix, Arizona"},{"name":"Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E A","family":"Jacobsen","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Rank","sequence":"first","affiliation":[{"name":"Division of Allergy, Asthma and Clinical Immunology, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E S","family":"Dellon","sequence":"first","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J J","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,12,8]]},"reference":[{"key":"2020070110140235700_bib1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/apt.13129","article-title":"The increasing incidence and prevalence of eosinophilic oesophagitis outpaces changes in endoscopic and biopsy practice: national population-based estimates from Denmark","volume":"41","author":"Dellon","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"2020070110140235700_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2011.02.040","article-title":"Eosinophilic esophagitis: updated consensus recommendations for children and adults","volume":"128","author":"Liacouras","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"2020070110140235700_bib3","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/j.jaci.2012.03.023","article-title":"Comparative dietary therapy effectiveness in remission of pediatric eosinophilic esophagitis","volume":"129","author":"Henderson","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"2020070110140235700_bib4","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.jaci.2012.06.027","article-title":"Selective elimination diet based on skin testing has suboptimal efficacy for adult eosinophilic esophagitis","volume":"130","author":"Molina-Infante","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"2020070110140235700_bib5","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jaip.2015.05.015","article-title":"IgE antibody detection and component analysis in patients with eosinophilic esophagitis","volume":"3","author":"Erwin","year":"2015","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2020070110140235700_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/apt.13676","article-title":"Allergy tests do not predict food triggers in adult patients with eosinophilic oesophagitis. 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