{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:53:16Z","timestamp":1780084396588,"version":"3.54.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:00:00Z","timestamp":1533600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Laryngopharyngeal reflux (LPR) is a clinical entity diagnosed by history laryngoscopic findings that has a variable response to empiric proton-pump inhibitor (PPI) therapy. While the reflux finding score (RFS), an endoscopic scoring scheme, has been advanced as a measure of LPR, it has not been externally validated against symptom severity in practice. Extralaryngeal pharyngeal endoscopic findings may have diagnostic utility but remain underexplored. This study assesses the correlation between extralaryngeal findings and (1) 24-hour oropharyngeal pH &amp; (2) PPI response in patients with suspected LPR. Subjects presented to a tertiary care center with laryngeal symptoms \u22651 month and reflux symptom index (RSI) \u226513. Following baseline questionnaires, laryngoscopy, and a 24-hour oropharyngeal pH probe study, subjects were prescribed 8\u201312 week omeprazole trials. Baseline endoscopic findings were scored in a blinded fashion using the RFS and extralaryngeal score criteria, summatively the \u2018ELS.\u2019 PPI response was defined as \u226550% improvement in RSI. Thirty-three subjects with flexible endoscopic recordings completed baseline and follow-up questionnaires. The cohort's baseline mean RSI was 23.0\u00a0\u00b1\u00a07.2 with a \u0394RSI\u00a0=\u00a09.8 after PPI therapy. The baseline RFS score averaged 5.3\u00a0\u00b1\u00a02.7. 45% of our subjects was found to be PPI responsive. The Cohen's kappa for the ELS but not the RFS was significant. There were no significant differences between the RFS (P\u00a0=\u00a00.10) or ELS (P\u00a0=\u00a00.07) for PPI responders &amp; nonresponders. Oropharyngeal pH measures did not correlate with the RFS or ELS. In conclusion, endoscopic scores of laryngeal and extralaryngeal findings did not predict PPI response or oropharyngeal acid exposure in suspected LPR.<\/jats:p>","DOI":"10.1093\/dote\/doy072","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T12:45:11Z","timestamp":1533645911000},"source":"Crossref","is-referenced-by-count":22,"title":["Relationship between extralaryngeal endoscopic findings, proton pump inhibitor (PPI) response, and pH measures in suspected laryngopharyngeal reflux"],"prefix":"10.1093","volume":"32","author":[{"given":"N","family":"Agrawal","sequence":"first","affiliation":[{"name":"Department of Otolaryngology - Head and Neck Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Yadlapati","sequence":"additional","affiliation":[{"name":"Division of Medicine - Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Shabeeb","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C PE","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology - Head and Neck Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lidder","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine and Dentistry, Rochester, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Shintani-Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology - Head and Neck Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bov\u00e9","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology - Head and Neck Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Pandolfino","sequence":"additional","affiliation":[{"name":"Division of Medicine - Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology - Head and Neck Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,8,7]]},"reference":[{"key":"2020071622581198400_bib1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jvoice.2005.10.006","article-title":"Symptoms of extraesophageal reflux in a community-dwelling sample","volume":"21","author":"Connor","year":"2007","journal-title":"J 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