{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:26:55Z","timestamp":1762918015183,"version":"3.41.2"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Esophageal Cancer Research Honoring Claude Deschamps","award":["UO1CA182940"],"award-info":[{"award-number":["UO1CA182940"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,30]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n               <jats:p>Image interpretation of Barrett's esophagus (BE) with volumetric laser endomicroscopy (VLE) can be enhanced by image processing software that highlights established features using a color-graded scale (intelligent real-time image segmentation, IRIS). This study aims to provide a description of IRIS features of various gastroesophageal tissue types using histologic correlation. A database of 80 VLE laser-marked targets with histologic correlation was reviewed for various tissue types. IRIS was applied off-line to the VLE scans, laser-marked targets were identified, and feature review was performed. Squamous epithelium targets (N = 7) showed IRIS layered architecture with lack of surface hyper-reflectivity and epithelial glands. Gastric cardia targets (N = 10) showed absent layering (100%) and surface hyper-reflectivity with epithelial glands (40%). Nondysplastic BE targets (N = 39) showed surface hyper-reflectivity (64%), epithelial glands (51%), and lack of layering (74%). Targets of BE with early neoplasia (N = 24), showed surface hyper-reflectivity (96%), epithelial glands (67%), and lack of layering (96%). IRIS features that characterize each tissue type appear to mirror the nonenhanced VLE counterparts that define them.<\/jats:p>","DOI":"10.1093\/dote\/doz037","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T05:59:30Z","timestamp":1557381570000},"source":"Crossref","is-referenced-by-count":6,"title":["Interpretation of volumetric laser endomicroscopy in Barrett's esophagus using image enhancement software"],"prefix":"10.1093","volume":"32","author":[{"given":"A K","family":"Kamboj","sequence":"first","affiliation":[{"name":"Department of Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Hoversten","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A K","family":"Kahn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Trindade","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Long Island Jewish Medical Center, Northwell Health System, New Hyde Park, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P G","family":"Iyer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K K","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C L","family":"Leggett","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"key":"2020010600175885500_bib1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/MOG.0000000000000366","article-title":"Volumetric laser endomicroscopy in the management of Barrett's esophagus","volume":"33","author":"Trindade","year":"2017","journal-title":"Curr Opin Gastroenterol"},{"key":"2020010600175885500_bib2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0016-5107(00)70449-4","article-title":"High-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography","volume":"51","author":"Bouma","year":"2000","journal-title":"Gastrointest Endosc"},{"key":"2020010600175885500_bib3","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1111\/jgh.14153","article-title":"Volumetric laser endomicroscopy interpretation and feature analysis in dysplastic Barrett's 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identify intramucosal carcinoma and High-Grade dysplasia in Barrett's esophagus","volume":"4","author":"Evans","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2020010600175885500_bib7","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.gie.2015.08.050","article-title":"Comparative diagnostic performance of volumetric laser endomicroscopy and confocal laser endomicroscopy in the detection of dysplasia associated with Barrett's esophagus","volume":"83","author":"Leggett","year":"2016","journal-title":"Gastrointest Endosc"},{"key":"2020010600175885500_bib8","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.gie.2016.09.012","article-title":"Identification of volumetric laser endomicroscopy features predictive for early neoplasia in Barrett's esophagus using high-quality histological correlation","volume":"85","author":"Swager","year":"2017","journal-title":"Gastrointest Endosc"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/dote\/article-pdf\/32\/11\/doz037\/31636612\/doz037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/dote\/article-pdf\/32\/11\/doz037\/31636612\/doz037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T05:18:08Z","timestamp":1578287888000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article\/doi\/10.1093\/dote\/doz037\/5487249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,9]]},"references-count":8,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,5,9]]},"published-print":{"date-parts":[[2019,12,30]]}},"URL":"https:\/\/doi.org\/10.1093\/dote\/doz037","relation":{},"ISSN":["1120-8694","1442-2050"],"issn-type":[{"type":"print","value":"1120-8694"},{"type":"electronic","value":"1442-2050"}],"subject":[],"published-other":{"date-parts":[[2019,11]]},"published":{"date-parts":[[2019,5,9]]},"article-number":"doz037"}}