{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:47:28Z","timestamp":1788968848542,"version":"build-2803163510"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Science Research Promotion Fund of the Promotion"},{"name":"Mutual Aid Corporation for Private Schools of Japan"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>We aimed to evaluate the effect of a Japanese herbal medicine, Hochu\u2010ekki\u2010to (TJ\u201041), on daily activity in a murine model of chronic fatigue syndrome (CFS).  CFS was induced by repeated injection of <jats:italic>Brucella abortus<\/jats:italic> (BA) antigen every 2 weeks. TJ\u201041 was orally administered to mice in a dose of 500\u2009mg\/kg\/day for 1 week before injecting BA and for 4 weeks thereafter. We evaluated daily running activity in mice receiving TJ\u201041 as compared with that in untreated mice.  Survival of both mouse groups was also monitored during the observation period.  Body weight (BW), spleen weight (SW), SW\/ BW ratio and expression levels of interleukin\u201010 (IL\u201010) mRNA in spleen were determined in both groups at the time of sacrifice.  The daily activity was significantly higher in the treated group than in the control.  Two mice in the untreated group died 2 days after the second injection of BA, whereas no mice in the group treated with TJ\u201041 died.  The SW and SW\/BW ratio were significantly lower in the treated mice than in the control. Suppressed IL\u201010 mRNA levels were observed in the spleens of the mice treated with TJ\u201041.  Our data suggest that Hochu\u2010ekki\u2010to might possess an inhibitory effect on the marked decrease in running activity following BA injection.<\/jats:p>","DOI":"10.1093\/ecam\/neh020","type":"journal-article","created":{"date-parts":[[2004,8,5]],"date-time":"2004-08-05T00:12:50Z","timestamp":1091664770000},"page":"203-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effect of Hochu\u2010ekki\u2010to (TJ\u201041), a Japanese Herbal Medicine, on Daily Activity in a Murine Model of Chronic Fatigue Syndrome"],"prefix":"10.1155","volume":"1","author":[{"given":"Xin Q.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-jie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Moriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichiro","family":"Saegusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2032ichi","family":"Yamakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Kusaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsugiyasu","family":"Kanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,3,26]]},"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2004\/569567.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1093\/ecam\/neh020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T15:23:06Z","timestamp":1723130586000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1093\/ecam\/neh020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1093\/ecam\/neh020"],"URL":"https:\/\/doi.org\/10.1093\/ecam\/neh020","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"2004-03-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}