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The results indicated that rats showed a significant preference to the 2\u2009Hz EA\u2010paired compartment. This rewarding effect of EA was prevented by pre\u2010treatment with the opioid receptor antagonist naloxone [2\u2009mg kg<jats:sup>\u22121<\/jats:sup>, intraperitoneally (i.p.)], CB1 cannabinoid antagonist AM251 (3\u2009<jats:italic>\u03bc<\/jats:italic>g per rat, intracerebroventricularly) or D1 dopamine receptor antagonist SCH23390 (0.1 mg kg<jats:sup>\u22121<\/jats:sup>, i.p.), respectively. TempspacetempspaceIt is concluded that 2\u2009Hz EA is capable of inducing CPP in the rat via the activation of the endogenous opioid\u2010, cannabinoid\u2010 and dopamine\u2010systems.<\/jats:p>","DOI":"10.1093\/ecam\/nen043","type":"journal-article","created":{"date-parts":[[2008,6,20]],"date-time":"2008-06-20T00:26:52Z","timestamp":1213921612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Electroacupuncture of 2\u2009Hz Has a Rewarding Effect: Evidence from a Conditioned Place Preference Study in Rats"],"prefix":"10.1155","volume":"2011","author":[{"given":"Wei","family":"Xia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning-Ning","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Sheng","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai-Lian","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,9]]},"reference":[{"key":"e_1_2_5_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20103223(97)00394\u20106"},{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(05)80120-2"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(94)90416-2"},{"key":"e_1_2_5_4_2","first-page":"241","article-title":"Inhibition by peripheral electric stimulation of the reinstatement of morphine-induced place preference in rats and drug-craving in heroin addicts","volume":"85","author":"Wang B.","year":"2003","journal-title":"Journal of Peking University (Health Sciences)"},{"key":"e_1_2_5_5_2","first-page":"239","article-title":"2\/100 Hz transcutaneous electrical stimulation for the treatment of heroine addiction","volume":"31","author":"Wu L. 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