{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:20:20Z","timestamp":1785345620282,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T00:00:00Z","timestamp":1308700800000},"content-version":"vor","delay-in-days":172,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Perillae Herba (a leaf of <jats:italic>Perilla frutescens<\/jats:italic>) has been prescribed as one of the component herbs in certain Kampo (Japanese herbal) medicines that are used clinically for the improvement of depressive mood. <jats:italic>l<\/jats:italic>\u2010Perillaldehyde (PAH) is a major component in the essential oil containing in Perillae Herba, but its antidepressant\u2010like effect has not been reported. To clarify the antidepressant\u2010like effect of PAH, the inhaled effect of PAH on stress\u2010induced depression\u2010like model mice prepared by subjection to a combination of forced swimming and chronic mild stresses was investigated. The degree of the depression\u2010like state was measured by the animal\u2032s duration of immobility using a forced swimming test. Inhalation of PAH (0.0965 and 0.965 mg\/mouse\/day, 9 days) significantly shortened the duration of immobility of the depression\u2010like model mice and did not affect locomotor activity. However, another odor substance, cinnamaldehyde containing in Cinnamomi Cortex, exhibited no reduction in the immobility. The reduction in the immobility induced by the inhalation of PAH was prevented on anosmia\u2010induced mice prepared by intranasal irrigation with zinc sulfate. These results suggest that the inhalation of PAH shows antidepressant\u2010like activity through the olfactory nervous function.<\/jats:p>","DOI":"10.1093\/ecam\/nen045","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T00:54:11Z","timestamp":1216256051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Antidepressant\u2010like Effect of <i>l<\/i>\u2010perillaldehyde in  Stress\u2010induced Depression\u2010like Model Mice through  Regulation of the Olfactory Nervous System"],"prefix":"10.1155","volume":"2011","author":[{"given":"N.","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Oikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Hanawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,22]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.138"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0924\u2010977X(95)00020\u2010P"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2006.01.002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20108741(00)00242\u20107"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014\u20102999(02)02037\u2010X"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1037\/1064\u20101297.5.2.107"},{"key":"e_1_2_6_7_2","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt R. 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Neuropharmacological action of water extract and perillaldehyde","volume":"101","author":"Sugaya A.","year":"1981","journal-title":"Yakugaku Zasshi"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/238454a0"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6773(74)90531-8"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109384(74)90096\u20101"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2011\/512697.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2011\/512697.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1093\/ecam\/nen045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T19:33:21Z","timestamp":1718134401000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1093\/ecam\/nen045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1093\/ecam\/nen045"],"URL":"https:\/\/doi.org\/10.1093\/ecam\/nen045","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"2007-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-05-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"512697"}}