{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:49:39Z","timestamp":1753876179229,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,5,3]],"date-time":"2011-05-03T00:00:00Z","timestamp":1304380800000},"content-version":"vor","delay-in-days":122,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>The effects of keishibukuryogan on the early stage of progressive renal failure were examined in rats subjected to 5\/6 nephrectomy. Keishibukuryogan, one of the traditional herbal formulations, was given orally at a dose of 1% (w\/w) and 3% (w\/w) in chow. Administration of keishibukuryogan was started at 1 week after 5\/6 nephrectomy and was continued for 4 weeks. At the end of the experiment, Azan staining did not reveal any severe histological changes in the kidneys of the nephrectomized rats. On the other hand, significant increases in mRNA expressions of transforming growth factor\u2010<jats:italic>\u03b2<\/jats:italic><jats:sub>1<\/jats:sub> and fibronectin related to tissue fibrosis, as examined by Reverse Transcriptase\u2010Polymerase Chain Reaction, were observed in nephrectomized rats, and they were significantly suppressed by 3% keishibukuryogan treatment. Against gene expressions related to macrophage infiltration, 3% keishibukuryogan treatment significantly suppressed osteopontin mRNA levels, and monocyte chemoattractant protein\u20101 and vascular cell adhesion molecule\u20101 mRNA levels showed a tendency to decrease, but without statistical significance. It was also observed that 3% keishibukuryogan attenuated serum urea nitrogen and urinary protein excretion levels. From these results, it was suggested that keishibukuryogan exerts beneficial effects that result in slowing the progression of chronic renal failure.<\/jats:p>","DOI":"10.1093\/ecam\/nep089","type":"journal-article","created":{"date-parts":[[2009,7,25]],"date-time":"2009-07-25T00:35:02Z","timestamp":1248482102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Keishibukuryogan Reduces Renal Injury in the Early Stage of Renal Failure in the Remnant Kidney Model"],"prefix":"10.1155","volume":"2011","author":[{"given":"Takako","family":"Nakagawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Oka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirozo","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotoshi","family":"Shibahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,5,3]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(00)04728\u20100"},{"key":"e_1_2_7_2_2","first-page":"40","article-title":"Effects of Keishi-bukuryo-gan and Trapidil on the microcirculation in patients with cerebro-spinal vascular disease","volume":"9","author":"Itoh T.","year":"1992","journal-title":"Journal of Medical and Pharmaceutical Society of Wakan-Yaku"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1078\/094471103322331395"},{"key":"e_1_2_7_4_2","first-page":"251","article-title":"Effects of Keishi-bukuryo-gan on erythrocyte aggregability in patients with multiple old lacunar infarction","volume":"10","author":"Kohta K.","year":"1993","journal-title":"Journal of Medical and Pharmaceutical Society of Wakan-Yaku"},{"key":"e_1_2_7_5_2","first-page":"172","article-title":"The effect of Keishi-bukuryo-gan on blood viscosity and blood coagulation in normal subjects","volume":"4","author":"Tosa H.","year":"1987","journal-title":"Journal of Medical and Pharmaceutical Society of Wakan-Yaku"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nem049"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1078\/0944\u20107113\u201000336"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.945"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.09.043"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1976.50"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1981.241.1.F85"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000414791"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80312-X"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)90589-8"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2005.00412.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.3.430"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.128"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.42"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.95"},{"key":"e_1_2_7_20_2","first-page":"S221","article-title":"Macrophage and myofibroblast proliferation in remnant kidney: role of angiotensin II","volume":"51","author":"Wu L. 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