{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:40:50Z","timestamp":1790692850317,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,12]],"date-time":"2011-01-12T00:00:00Z","timestamp":1294790400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001791","name":"Griffith University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001791","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>To investigate the cytotoxic effect of some Bangladeshi medicinal plant extracts, 16 Bangladeshi medicinal plants were successively extracted with <jats:italic>n<\/jats:italic>\u2010hexane, dichloromethane, methanol and water. The methanolic and aqueous extracts were screened for cytotoxic activity against healthy mouse fibroblasts (NIH3T3) and three human cancer\u2010cell lines (gastric: AGS; colon: HT\u201029; and breast: MDA\u2010MB\u2010435S) using the MTT assay. Two methanolic extracts (<jats:italic>Hygrophila auriculata<\/jats:italic> and <jats:italic>Hibiscus tiliaceous<\/jats:italic>) and one aqueous extract (<jats:italic>Limnophila indica<\/jats:italic>) showed no toxicity against healthy mouse fibroblasts, but selective cytotoxicity against breast cancer cells (IC<jats:sub>50<\/jats:sub> 1.1\u20131.6\u2009mg\u2009mL<jats:sup>\u22121<\/jats:sup>). Seven methanolic extracts from <jats:italic>L. indica<\/jats:italic>, <jats:italic>Clerodendron inerme<\/jats:italic>, <jats:italic>Cynometra ramiflora<\/jats:italic>, <jats:italic>Xylocarpus moluccensis<\/jats:italic>, <jats:italic>Argemone mexicana<\/jats:italic>, <jats:italic>Ammannia baccifera<\/jats:italic> and <jats:italic>Acrostichum aureum<\/jats:italic> and four aqueous extracts from <jats:italic>Hygrophila auriculata<\/jats:italic>, <jats:italic>Bruguiera gymnorrhiza<\/jats:italic>, <jats:italic>X. moluccensis<\/jats:italic> and <jats:italic>Aegiceras corniculatum<\/jats:italic> showed low toxicity (IC<jats:sub>50<\/jats:sub> &gt; 2.5\u2009mg\u2009mL<jats:sup>\u22121<\/jats:sup>) against mouse fibroblasts but selective cytotoxicity (IC<jats:sub>50<\/jats:sub> 0.2\u20132.3\u2009mg\u2009mL<jats:sup>\u22121<\/jats:sup>) against different cancer cell lines. The methanolic extract of <jats:italic>Blumea lacera<\/jats:italic> showed the highest cytotoxicity (IC<jats:sub>50<\/jats:sub> 0.01\u20130.08\u2009mg\u2009mL<jats:sup>\u22121<\/jats:sup>) against all tested cell lines among all extracts tested in this study. For some of the plants their traditional use as anticancer treatments correlates with the cytotoxic results, whereas for others so far unknown cytotoxic activities were identified.<\/jats:p>","DOI":"10.1093\/ecam\/nep111","type":"journal-article","created":{"date-parts":[[2009,8,26]],"date-time":"2009-08-26T03:08:47Z","timestamp":1251256127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Cytotoxic Effects of Bangladeshi Medicinal Plant Extracts"],"prefix":"10.1155","volume":"2011","author":[{"given":"Shaikh J.","family":"Uddin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Darren","family":"Grice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelin","family":"Tiralongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,12]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/np068054v"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041\u20100101(00)00154\u20109"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20108741(00)00341\u2010X"},{"key":"e_1_2_6_4_2","volume-title":"Trade in Medicinal Plants","author":"FAO","year":"2004"},{"key":"e_1_2_6_5_2","volume-title":"Medicinal Plants of Bangladesh with Chemical Constituents and Uses","author":"Ghani A.","year":"2003"},{"key":"e_1_2_6_6_2","volume-title":"Medicinal Plants of Bangladesh","author":"Yusuf M.","year":"1994"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X04002284"},{"key":"e_1_2_6_8_2","first-page":"419","article-title":"Effects of extracts from Bangladeshi medicinal plants on in vitro proliferation of human breast cancer cell lines and expression of estrogen receptor alpha gene","volume":"24","author":"Lambertini E.","year":"2004","journal-title":"International Journal of Oncology"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/1573406054368684","article-title":"Bangladeshi medicinal plant extracts inhibiting molecular interactions between nuclear factors and target DNA sequences mimicking NF-kappaB binding sites","volume":"1","author":"Lampronti I.","year":"2005","journal-title":"Journal of Medicinal Chemistry"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102006\u2010931604"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.20186"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2007.06.004"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4314\/ajtcam.v5i2.31276","article-title":"Clerodendron inerme protects cellular integrity during 7,12-dimethylbenz [A]-anthracene induced hamster buccal pouch carcinogenesis","volume":"5","author":"Manoharan S.","year":"2008","journal-title":"African Journal of Traditional, Complementary and Alternative Medicines"},{"key":"e_1_2_6_14_2","volume-title":"Isolation and Identification of New Flavonoid from Bruguiera Gymnorhiza and Antitumor Applicaiton Thereof","author":"Ye B.","year":"2008"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nem042"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.05.021"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.2323\/jgam.54.101"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0885-4505(86)90129-5"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf061407b"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.09.030"},{"key":"e_1_2_6_21_2","first-page":"805","article-title":"Antioxidant activity and total phenolics of some mangroves in Sundarbans","volume":"7","author":"Banerjee D.","year":"2008","journal-title":"African Journal of Biotechnology"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.04.006"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762006000600011"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.09.018"},{"key":"e_1_2_6_25_2","volume-title":"Antimicrobial Aurone Derivatives","author":"McAlpine J. 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