{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:56:50Z","timestamp":1791089810742,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T00:00:00Z","timestamp":1313020800000},"content-version":"vor","delay-in-days":222,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>A number of potential anti\u2010diabetic plants were identified through an ethnobotanical survey of the traditional pharmacopeia of the Cree of Eeyou Istchee (CEI\u2014Northeastern Canada) used against symptoms of diabetes and their biological activity assessed by <jats:italic>in vitro<\/jats:italic> bioassays. Among these, <jats:italic>Sorbus decora<\/jats:italic> C.K.Schneid. (Rosacea) ranked highly and increased the transport of glucose in skeletal muscle cells in culture. The present study thus aimed at confirming the antidiabetic potential of <jats:italic>S. decora<\/jats:italic> in <jats:italic>in vivo<\/jats:italic> models of insulin resistance and diabetes, notably the streptozotocin Type 1 diabetic rat (STZ), the genetic KK\u2010A<jats:sup>y<\/jats:sup> Type 2 diabetic mouse and the rat rendered insulin resistant with 10% glucose water consumption for 6 weeks. <jats:italic>Sorbus decora<\/jats:italic> ethanolic crude extract (SDEE) was administered orally (200\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>) and compared to metformin (150 or 500\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>). The intragastric (i.g.) gavage of SDEE transiently decreased glycemia in STZ rats in a bi\u2010phasic manner but the effect was cumulative over several days. In KK\u2010A<jats:sup>y<\/jats:sup> mice, SDEE incorporated in food (0.12%) decreased glycemia by 15% within 1 week as compared to vehicle controls. In pre\u2010diabetic insulin\u2010resistant rats, SDEE fed daily by i.g. gavage for 2 weeks significantly decreased the slight hyperglycemia and hyperinsulinemia, without affecting sugar water intake. Using the HOMA insulin resistance parameter, the effect of SDEE was equivalent to that of metformin. In conclusion, the ethanolic crude extract of <jats:italic>S. decora<\/jats:italic> demonstrates both anti\u2010hyperglycemic and insulin\u2010sensitizing activity <jats:italic>in vivo<\/jats:italic>, thereby confirming anti\u2010diabetic potential and validating CEI traditional medicine.<\/jats:p>","DOI":"10.1093\/ecam\/nep158","type":"journal-article","created":{"date-parts":[[2009,11,4]],"date-time":"2009-11-04T04:34:14Z","timestamp":1257309254000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["<i>In Vivo<\/i> Anti\u2010Diabetic Activity of the Ethanolic Crude Extract of <i>Sorbus decora<\/i> C.K.Schneid. 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