{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:49:12Z","timestamp":1753876152593,"version":"3.41.2"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,2,14]],"date-time":"2011-02-14T00:00:00Z","timestamp":1297641600000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>In traditional Chinese medicine (TCM), purgation is indicated when a person suffers an illness due to the accumulation of evil internal heat. Obese individuals with a large belly, red face, thick and yellow tongue fur, constipation, and avoidance of heat are thought accumulates of evil internal heat, and they are also treated with purgatives such as <jats:italic>Ta-Cheng-Chi-Tang<\/jats:italic> (TCCT), <jats:italic>Xiao-Chen-Chi-Tang<\/jats:italic> (XCCT), and <jats:italic>Tiao-Wei-Chen-Chi-Tang<\/jats:italic> (TWCCT) by TCM doctors. In previous studies, our group found that TCCT has potent anti\u2010inflammatory activity, and that XCCT is an effective antioxidant. Since rhubarb is the principle herb in these three prescriptions, we will first present a thorough review of the literature on the demonstrated effect (or lack of effect) of rhubarb and rhubarb\u2010containing polyherbal preparations on lipid and weight control. We will then continue our research with an investigation of the anti\u2010obesity and lipid\u2010lowering effect of TCCT, XCCT, TWCCT, and rhubarb extracts using two animal models. TWCCT lowered the serum triglyceride concentration as much as fenofibrate in Triton WR\u20101339\u2010treated mice. Daily supplementation with XCCT and TWCCT significantly attenuated the high\u2010fat\u2010diet\u2010induced hypercholesterolemia in rats. In addition, TWCCT also significantly lowered the high\u2010fat\u2010diet\u2010induced hypertriglycemia. Although feeding high\u2010fat diet rats with these extracts did not cause loose stools or diarrhea or other deleterious effects on renal or hepatic function. None of these extracts lowered the body weight of rats fed on high\u2010fat diet. In conclusion, the results suggest that XCCT and TWCCT might exert beneficial effects in the treatment of hyperlipidemia.<\/jats:p>","DOI":"10.1093\/ecam\/nep178","type":"journal-article","created":{"date-parts":[[2009,10,31]],"date-time":"2009-10-31T00:45:08Z","timestamp":1256949908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hypolipidemic Effects of Three Purgative Decoctions"],"prefix":"10.1155","volume":"2011","author":[{"given":"Sung-Hui","family":"Tseng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Yi","family":"Chien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiun-Rong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I-Hsin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Chiung","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,14]]},"reference":[{"key":"e_1_2_7_1_2","first-page":"35","volume-title":"The Complete Guide of Chinese Medicine in Losing Weight and Reshaping Body","author":"Wu M. 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