{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:49:44Z","timestamp":1773272984146,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,2,14]],"date-time":"2011-02-14T00:00:00Z","timestamp":1297641600000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Infusions and decoctions of <jats:italic>Cymbopogon ambiguus<\/jats:italic> have been used traditionally in Australia for the treatment of headache, chest infections and muscle cramps. The aim of the present study was to screen and identify bioactive compounds from <jats:italic>C. ambiguus<\/jats:italic> that could explain this plant\u2019s anti\u2010headache activity. A dichloromethane extract of <jats:italic>C. ambiguus<\/jats:italic> was identified as having activity in adenosine\u2010diphosphate\u2010induced human platelet aggregation and serotonin\u2010release inhibition bioassays. Subsequent fractionation of this extract led to the isolation of four phenylpropenoids, eugenol, elemicin, eugenol methylether and <jats:italic>trans<\/jats:italic>\u2010isoelemicin. While both eugenol and elemicin exhibited dose\u2010dependent inhibition of ADP\u2010induced human platelet serotonin release, only eugenol displayed potent inhibitory activity with an IC<jats:sub>50<\/jats:sub> value of 46.6\u2009<jats:italic>\u03bc<\/jats:italic>M, in comparison to aspirin, with an IC<jats:sub>50<\/jats:sub> value of 46.1\u2009<jats:italic>\u03bc<\/jats:italic>M. These findings provide evidence to support the therapeutic efficacy of <jats:italic>C. ambiguus<\/jats:italic> in the non\u2010conventional treatment of headache and inflammatory conditions.<\/jats:p>","DOI":"10.1093\/ecam\/nep213","type":"journal-article","created":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T01:28:11Z","timestamp":1262654891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Isolation of Bioactive Compounds That Relate to the Anti\u2010Platelet Activity of <i>Cymbopogon ambiguus<\/i>"],"prefix":"10.1155","volume":"2011","author":[{"given":"I. 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