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We have earlier reported the reversal of diazepam\u2010induced amnesia with <jats:italic>B. monniera.<\/jats:italic> In this study we wanted to test if scopolamine\u2010induced impairment of spatial memory can also be ameliorated by <jats:italic>B. monniera<\/jats:italic> using water maze mouse model. The objective of study was to study the effect of <jats:italic>B. monniera<\/jats:italic> on scopolamine\u2010induced amnesia. We employed Morris water maze scale to test the amnesic effect of scopolamine and its reversal by <jats:italic>B. monniera.<\/jats:italic> Rotarod test was conducted to screen muscle coordination activity of mice. Scopolamine significantly impaired the acquisition and retrieval of memory producing both anterograde and retrograde amnesia. <jats:italic>Bacopa monniera<\/jats:italic> extract was able to reverse both anterograde and retrograde amnesia. We propose that <jats:italic>B. monniera\u2019s<\/jats:italic> effects on cholinergic system may be helpful for developing alternative therapeutic approaches for the treatment of Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.1093\/ecam\/neq038","type":"journal-article","created":{"date-parts":[[2010,5,8]],"date-time":"2010-05-08T00:34:34Z","timestamp":1273278874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["<i>Bacopa monniera<\/i> Attenuates Scopolamine\u2010Induced Impairment of Spatial Memory in Mice"],"prefix":"10.1155","volume":"2011","author":[{"given":"Manish Kumar","family":"Saraf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudesh","family":"Prabhakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishan Lal","family":"Khanduja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,13]]},"reference":[{"key":"e_1_2_7_1_2","first-page":"543","article-title":"Dementia current status","volume":"17","author":"Basu S.","year":"2003","journal-title":"Postgraduate Medicine"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102362.1998.00393.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03582.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050360"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.121847"},{"key":"e_1_2_7_6_2","series-title":"Fact Sheet, no. 134","volume-title":"Traditional Medicine","author":"W.H.O.","year":"2003"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091\u20103057(03)00128\u2010X"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1280"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1061"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S026646230200034X"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nem079"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nel024"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nek014"},{"key":"e_1_2_7_14_2","first-page":"24","article-title":"Chemical examination of Bacopa monniera Wettst\u2014part II: the constitution of Bacoside A","volume":"3","author":"Chatterji N.","year":"1965","journal-title":"Indian Journal of Chemistry"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(82)90044-7"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20108741(99)00213\u20105"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2003.12.008"},{"key":"e_1_2_7_18_2","unstructured":"DhawanB. 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